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Species-specific antagonism of Ah receptor action by 2,2',5,5'-tetrachloro- and 2,2',3,3'4,4'-hexachlorobiphenyl.
Aarts JM, Denison MS, Cox MA, Schalk MA, Garrison PM, Tullis K, de Haan LH, Brouwer A. Aarts JM, et al. Eur J Pharmacol. 1995 Dec 7;293(4):463-74. doi: 10.1016/0926-6917(95)90067-5. Eur J Pharmacol. 1995. PMID: 8748700
In the recombinant Hepa1c1c7 mouse hepatoma (H1L1.1c7) cells strong antagonistic interaction of 2,2',5,5'-tetrachlorobiphenyl (PCB52) with luciferase expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3',4,4'-tetrachlorobiphenyl (PCB77) was observed, and simila …
In the recombinant Hepa1c1c7 mouse hepatoma (H1L1.1c7) cells strong antagonistic interaction of 2,2',5,5'-tetrachlorobiphenyl (PCB52) with l …
Subchronic toxicity of 2,2',3,3',4,4'-hexachlorobiphenyl in rats.
Lecavalier P, Chu I, Yagminas A, Villeneuve DC, Poon R, Feeley M, Håkansson H, Ahlborg UG, Valli VE, Bergman A, Seegal RF, Kennedy SW. Lecavalier P, et al. J Toxicol Environ Health. 1997 Jun 27;51(3):265-77. doi: 10.1080/00984109708984026. J Toxicol Environ Health. 1997. PMID: 9183382
The subchronic toxicity of 2,2',3,3',4,4'-hexachlorobiphenyl (PCB 128) was investigated in rats following dietary exposure at 0, 0.05, 0.5, 5, or 50 ppm for 13 wk. ...
The subchronic toxicity of 2,2',3,3',4,4'-hexachlorobiphenyl (PCB 128) was investigated in rats following …
[Metabolism of 3,3',4,4',5-penta- and 2,2',3,3',4,4'-hexachlorobiphenyls in rats].
Haraguchi K, Hirose Y, Masuda Y, Kato Y, Kimura R. Haraguchi K, et al. Fukuoka Igaku Zasshi. 1999 May;90(5):210-9. Fukuoka Igaku Zasshi. 1999. PMID: 10396877 Japanese.
Following the i.p. administration of 3,3',4,4',5-pentachlorobiphenyl (CB126) and 2,2',3,3',4,4'-hexachlorobiphenyl (CB128) to rats, blood, liver, lung, kidney, adipose tissue and feces were analyzed for the metabolites. ...
Following the i.p. administration of 3,3',4,4',5-pentachlorobiphenyl (CB126) and 2,2',3,3',4,4'-hexachlorobip …
Neutrophil activation by polychlorinated biphenyls: structure-activity relationship.
Brown AP, Olivero-Verbel J, Holdan WL, Ganey PE. Brown AP, et al. Toxicol Sci. 1998 Dec;46(2):308-16. doi: 10.1006/toxs.1998.2551. Toxicol Sci. 1998. PMID: 10048134
Incubation of neutrophils with 4,4'-DCB, 3,3',4,4',5-pentachlorobiphenyl (3,3',4,4',5-PeCB), 3,3',4,5,5'-PeCB, or 2,2',3,3',4,4'-hexachlorobiphenyl (2,2',3,3',4,4'-HCB) did not result in generation of O2-. ...
Incubation of neutrophils with 4,4'-DCB, 3,3',4,4',5-pentachlorobiphenyl (3,3',4,4',5-PeCB), 3,3',4,5,5'-PeCB, or 2,2',3 …
Inhibition of L-aromatic amino acid decarboxylase by polychlorinated biphenyls.
Angus WG, Mousa MA, Vargas VM, Quensen JF, Boyd SA, Contreras ML. Angus WG, et al. Neurotoxicology. 1997;18(3):857-67. Neurotoxicology. 1997. PMID: 9339832
In cells treated 3 days with Aroclor 1254, 2,2',5,5'-tetrachlorobiphenyl (2,2',5,5'-TCB), or 2,2',3,3',4,4'-hexachlorobiphenyl (2,2',3,3',4,4'-HCB), the PCB-mediated reduction in 3H-tyrosine uptake was observed …
In cells treated 3 days with Aroclor 1254, 2,2',5,5'-tetrachlorobiphenyl (2,2',5,5'-TCB), or 2,2',3,3',4, …
Effect of three polychlorinated biphenyls on f-met-leu-phe-induced degranulation in rat neutrophils.
Olivero-Verbel J, Ganey PE. Olivero-Verbel J, et al. Toxicol Lett. 1998 Sep 15;98(3):195-202. doi: 10.1016/s0378-4274(98)00117-9. Toxicol Lett. 1998. PMID: 9788588
Structure-activity relationships for congeners PCB 8 (2,4'-dichlorobiphenyl), PCB 126 (3,3',4,4',5-pentachlorobiphenyl) and PCB 128 (2,2',3,3',4,4'-hexachlorobiphenyl) were examined by correlating the extent of degranulation and cytotoxicity wit …
Structure-activity relationships for congeners PCB 8 (2,4'-dichlorobiphenyl), PCB 126 (3,3',4,4',5-pentachlorobiphenyl) and PCB 128 (2 …
Effects of polychlorinated biphenyls on dopamine release from PC12 cells.
Angus WG, Contreras ML. Angus WG, et al. Toxicol Lett. 1996 Dec 31;89(3):191-9. doi: 10.1016/s0378-4274(96)03810-6. Toxicol Lett. 1996. PMID: 9001587
Absent of any apparent cytotoxicity, the ortho-substituted PCB congeners 2,2',5,5'-tetrachlorobiphenyl, 2,2',3,3',4,4'-hexachlorobiphenyl, 2,3',4,4',5-pentachlorobiphenyl, and 2,2',4,4',5,5'-hexachlorobiphenyl …
Absent of any apparent cytotoxicity, the ortho-substituted PCB congeners 2,2',5,5'-tetrachlorobiphenyl, 2,2',3,3 …
Effects of ortho- and non-ortho-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops).
Gooch JW, Elskus AA, Kloepper-Sams PJ, Hahn ME, Stegeman JJ. Gooch JW, et al. Toxicol Appl Pharmacol. 1989 May;98(3):422-33. doi: 10.1016/0041-008x(89)90171-3. Toxicol Appl Pharmacol. 1989. PMID: 2497554
Scup were dosed ip with 3,3',4,4'-tetrachlorobiphenyl (congener 77), 2,3,3',4,4'-pentachlorobiphenyl (congener 105), 2,3',4,4',5-pentachlorobiphenyl (congener 118), 2,2',3,4,4',5'-hexachlorobiphenyl (congener 138), 2,2',3,3' …
Scup were dosed ip with 3,3',4,4'-tetrachlorobiphenyl (congener 77), 2,3,3',4,4'-pentachlorobiphenyl (congener 105), 2,3',4,4',5-pentachloro …
Vesicular catecholamine release from rat PC12 cells on acute and subchronic exposure to polychlorinated biphenyls.
Westerink RH, Vijverberg HP. Westerink RH, et al. Toxicol Appl Pharmacol. 2002 Sep 15;183(3):153-9. doi: 10.1006/taap.2002.9482. Toxicol Appl Pharmacol. 2002. PMID: 12383706
Subsequent exposure of the same cells to saline containing the nonplanar congener 2,2'-dichlorobiphenyl (PCB 4) and the coplanar congener 3,3',4,4',5-pentachlorobiphenyl (PCB 126) at concentrations between 5 and 25 microM for 15 min caused an enhancement of the frequency of basal …
Subsequent exposure of the same cells to saline containing the nonplanar congener 2,2'-dichlorobiphenyl (PCB 4) and the coplanar congener 3, …
Effects of PCB congeners on the immune function of Mytilus hemocytes: alterations of tyrosine kinase-mediated cell signaling.
Canesi L, Ciacci C, Betti M, Scarpato A, Citterio B, Pruzzo C, Gallo G. Canesi L, et al. Aquat Toxicol. 2003 May 8;63(3):293-306. doi: 10.1016/s0166-445x(02)00186-8. Aquat Toxicol. 2003. PMID: 12711418
However, chlorine substitution at the ortho positions is not necessarily related to immunotoxicity: the hexachlorinated P128 (2,2',3,3',4,4'-hexachlorobiphenyl) had no significant effect on mussel hemocytes, whereas its isomer P153, that represe …
However, chlorine substitution at the ortho positions is not necessarily related to immunotoxicity: the hexachlorinated P128 (2,2 …
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