Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1984 1
1986 1
1988 1
1997 1
1999 1
2007 2
2008 4
2009 1
2011 2
2013 2
2014 4
2015 2
2016 1
2017 2
2018 1
2019 2
2021 1
2022 1
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

27 results

Results by year

Filters applied: . Clear all
Page 1
Metabolic activation mechanism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB136) by cytochrome P450 2B6: A QM/MM approach.
Zhu L, Huo X, Zhou J, Zhang Q, Wang W. Zhu L, et al. Sci Total Environ. 2021 Jul 1;776:145579. doi: 10.1016/j.scitotenv.2021.145579. Epub 2021 Feb 4. Sci Total Environ. 2021. PMID: 33652317
The present work implemented quantum mechanic/molecular mechanic methods (QM/MM) and density functional theory (DFT) to study the metabolic activation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB136) catalyzed by CYP2B6. Electrophilic additions at …
The present work implemented quantum mechanic/molecular mechanic methods (QM/MM) and density functional theory (DFT) to study the metabolic …
Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl by human hepatic microsomes.
Schnellmann RG, Putnam CW, Sipes IG. Schnellmann RG, et al. Biochem Pharmacol. 1983 Nov 1;32(21):3233-9. doi: 10.1016/0006-2952(83)90209-5. Biochem Pharmacol. 1983. PMID: 6416258
Since the metabolism of polychlorinated biphenyls (PCBs) is the critical factor that determines whether or not they accumulate in adipose tissue, we have studied the metabolism of two hexachlorobiphenyls (HCBs), 2,2'3,3',6,6'-hexachlorobiphenyl …
Since the metabolism of polychlorinated biphenyls (PCBs) is the critical factor that determines whether or not they accumulate in adipose ti …
Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice.
Wu X, Barnhart C, Lein PJ, Lehmler HJ. Wu X, et al. Environ Sci Technol. 2015 Jan 6;49(1):616-25. doi: 10.1021/es504766p. Epub 2014 Dec 10. Environ Sci Technol. 2015. PMID: 25420130 Free PMC article.
Feces was a major route of PCB metabolite excretion, with 2,2',3,3',6,6'-hexachlorobiphenyl-5-ol being the major metabolite recovered from feces. (+)-PCB 136, the second eluting PCB 136 atropisomers, was enriched in all tissues and excreta. The …
Feces was a major route of PCB metabolite excretion, with 2,2',3,3',6,6'-hexachlorobiphenyl-5-ol being th …
Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes.
Wu X, Lehmler HJ. Wu X, et al. Environ Sci Pollut Res Int. 2016 Feb;23(3):2081-8. doi: 10.1007/s11356-015-4987-4. Epub 2015 Jul 9. Environ Sci Pollut Res Int. 2016. PMID: 26155892 Free PMC article.
Liver microsomes prepared from rats pretreated with phenobarbital were incubated with PCB 136 (5 muM) in the presence of the respective antioxidant (0-10 mM), and levels and chiral signatures of PCB 136 and its HO-PCB metabolites were determined. Three metabolites, 5-136 (2 …
Liver microsomes prepared from rats pretreated with phenobarbital were incubated with PCB 136 (5 muM) in the presence of the respective anti …
Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2.
Pessah IN, Lehmler HJ, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. Pessah IN, et al. Chem Res Toxicol. 2009 Jan;22(1):201-7. doi: 10.1021/tx800328u. Chem Res Toxicol. 2009. PMID: 18954145 Free PMC article.
Polychlorinated biphenyls (PCBs) with unsymmetrical chlorine substitutions and multiple orthosubstitutions that restrict rotation around the biphenyl bond may exist in two stable enantiomeric forms.Stereospecific binding and functional modification of specific biological signalin …
Polychlorinated biphenyls (PCBs) with unsymmetrical chlorine substitutions and multiple orthosubstitutions that restrict rotation around the …
2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes.
Kania-Korwel I, Hrycay EG, Bandiera SM, Lehmler HJ. Kania-Korwel I, et al. Chem Res Toxicol. 2008 Jun;21(6):1295-303. doi: 10.1021/tx800059j. Epub 2008 May 22. Chem Res Toxicol. 2008. PMID: 18494506 Free PMC article.
2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is a chiral and highly neurotoxic PCB congener of environmental relevance. (+)-PCB 136 was previously shown to be enriched in tissues from mice treated with racemic PCB 136. ...
2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is a chiral and highly neurotoxic PCB congener of environment …
Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites.
Wu X, Kammerer A, Lehmler HJ. Wu X, et al. Environ Sci Technol. 2014 Feb 18;48(4):2436-44. doi: 10.1021/es405433t. Epub 2014 Feb 5. Environ Sci Technol. 2014. PMID: 24467194 Free PMC article.
To investigate this hypothesis, we incubated PCB 136, a representative chiral PCB, with pooled human liver microsomes (HLMs) or liver microsomes from male guinea pig, hamster, monkey, mouse, and rabbit or female dog and determined average profiles and chiral signatures of the OH- …
To investigate this hypothesis, we incubated PCB 136, a representative chiral PCB, with pooled human liver microsomes (HLMs) or liver micros …
2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes.
Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler HJ, Kania-Korwel I. Wu X, et al. Chem Res Toxicol. 2011 Dec 19;24(12):2249-57. doi: 10.1021/tx200360m. Epub 2011 Nov 10. Chem Res Toxicol. 2011. PMID: 22026639 Free PMC article.
The results demonstrated the time- and isoform-dependent formation of three metabolites, with 5-OH-PCB 136 (2,2',3,3',6,6'-hexachlorobiphenyl-5-ol) being the major metabolite. The formation of 5-OH-PCB 136 increased with the activity of P450 2B …
The results demonstrated the time- and isoform-dependent formation of three metabolites, with 5-OH-PCB 136 (2,2',3,3', …
27 results