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2,2',4,6,6'-pentachlorobiphenyl induces apoptosis in human monocytic cells.
Shin KJ, Bae SS, Hwang YA, Seo JK, Ryu SH, Suh PG. Shin KJ, et al. Toxicol Appl Pharmacol. 2000 Nov 15;169(1):1-7. doi: 10.1006/taap.2000.9034. Toxicol Appl Pharmacol. 2000. PMID: 11076690
In the present study, we investigated the effect of PCBs on immune system by assessing apoptotic cell death in human monocytic U937 cells. Among the various congeners tested, 2,2',4,6, 6'-pentachlorobiphenyl (PeCB), a highly ortho-substit …
In the present study, we investigated the effect of PCBs on immune system by assessing apoptotic cell death in human monocytic U937 cells. A …
2,2',4,6,6'-Pentachlorobiphenyl-induced apoptosis is limited by cyclooxygenase-2 induction.
Kim SH, Kim YH, Shin KJ, Oh YS, Lee CS, Kang KO, Ryu SH, Suh PG. Kim SH, et al. Toxicol Sci. 2005 Feb;83(2):397-404. doi: 10.1093/toxsci/kfi026. Epub 2004 Nov 3. Toxicol Sci. 2005. PMID: 15525691
Among the several congeners examined, only 2,2',4,6,6'-pentachlorobiphenyl (PeCB) specifically increased the COX-2 promoter activity, and the levels of COX-2 mRNA and protein, and thereby enhanced prostaglandin E2 (PGE2) synthesis in Rat- …
Among the several congeners examined, only 2,2',4,6,6'-pentachlorobiphenyl (PeCB) specifically inc …
2,2',4,6,6'-Pentachlorobiphenyl induces mitotic arrest and p53 activation.
Shin KJ, Kim SH, Kim D, Kim YH, Lee HW, Chang YS, Gu MB, Ryu SH, Suh PG. Shin KJ, et al. Toxicol Sci. 2004 Apr;78(2):215-21. doi: 10.1093/toxsci/kfh069. Epub 2004 Jan 21. Toxicol Sci. 2004. PMID: 14737002
Various cancers are closely related to genetic alteration; therefore, we investigated the effect of PCBs on genetic stability, through p53, a guardian of genome, in NIH 3T3 fibroblasts. Among several congeners examined, 2,2',4,6,6'-pentachlor …
Various cancers are closely related to genetic alteration; therefore, we investigated the effect of PCBs on genetic stability, through p53, …
2,2',4,6,6'-pentachlorobiphenyl (PCB 104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB.
Lee YW, Park HJ, Son KW, Hennig B, Robertson LW, Toborek M. Lee YW, et al. Toxicol Appl Pharmacol. 2003 May 15;189(1):1-10. doi: 10.1016/s0041-008x(03)00084-x. Toxicol Appl Pharmacol. 2003. PMID: 12758055
A significant and marked decrease in cell viability was observed in HMEC-1 treated with 2,2',4,6,6'-pentachlorobiphenyl (PCB 104) in a time- and dose-dependent manner. Exposure of HMEC-1 to PCB 104 also dramatically induced internucleosom …
A significant and marked decrease in cell viability was observed in HMEC-1 treated with 2,2',4,6,6'-pe …
Determination of hydroxylated polychlorinated biphenyls (HO-PCBs) in blood plasma by high-performance liquid chromatography-electrospray ionization-tandem quadrupole mass spectrometry.
Letcher RJ, Li HX, Chu SG. Letcher RJ, et al. J Anal Toxicol. 2005 May-Jun;29(4):209-16. doi: 10.1093/jat/29.4.209. J Anal Toxicol. 2005. PMID: 15975248
LC-ESI(-)-MS identified four HO-PCB congeners [4'-HO-2,2',4,6,6'-pentachlorobiphenyl (4'-HO-CB104), 4-HO-2,3,3',4',5-pentachlorobiphenyl (4-HO-CB107), 4-HO-2,3,3',5,5',6-hexachlorobiphenyl (4-HO-CB165) and 3'-HO-2,2',3,4,4',5,5'-heptachlo …
LC-ESI(-)-MS identified four HO-PCB congeners [4'-HO-2,2',4,6,6'-pentachlorobiphenyl (4'-HO-CB104) …
Ortho-substituted polychlorinated biphenyls alter calcium regulation by a ryanodine receptor-mediated mechanism: structural specificity toward skeletal- and cardiac-type microsomal calcium release channels.
Wong PW, Pessah IN. Wong PW, et al. Mol Pharmacol. 1996 Apr;49(4):740-51. Mol Pharmacol. 1996. PMID: 8609904
In contrast, 3,3',4,4',5-pentachlorobiphenyl does not enhance ryanodine binding, suggesting that noncoplanarity of the biphenyl rings is required for channel activation. However, 2,2',4,6,6'-pentachlorobiphenyl is significantly less activ …
In contrast, 3,3',4,4',5-pentachlorobiphenyl does not enhance ryanodine binding, suggesting that noncoplanarity of the biphenyl rings is req …
Increased [3H]phorbol ester binding in rat cerebellar granule cells by polychlorinated biphenyl mixtures and congeners: structure-activity relationships.
Kodavanti PR, Ward TR, McKinney JD, Tilson HA. Kodavanti PR, et al. Toxicol Appl Pharmacol. 1995 Jan;130(1):140-8. doi: 10.1006/taap.1995.1018. Toxicol Appl Pharmacol. 1995. PMID: 7839361
Of the 24 congeners studied, di-ortho congeners such as 2,2',5,5'-tetrachlorobiphenyl (-TeCB), 2,2',4,6,6'-pentachlorobiphenyl (-PeCB), 2,2',4,6-TeCB, and 2,2'-dichlorobiphenyl (-DCB) were the most potent (E50 = 28-43 microM) while non-or …
Of the 24 congeners studied, di-ortho congeners such as 2,2',5,5'-tetrachlorobiphenyl (-TeCB), 2,2',4,6,6 …
Assessment of PCBs and hydroxylated PCBs as potential xenoestrogens: In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes.
Andersson PL, Blom A, Johannisson A, Pesonen M, Tysklind M, Berg AH, Olsson PE, Norrgren L. Andersson PL, et al. Arch Environ Contam Toxicol. 1999 Aug;37(2):145-50. doi: 10.1007/s002449900499. Arch Environ Contam Toxicol. 1999. PMID: 10398763
A human breast cancer cell line (MCF-7) and primary cultures of rainbow trout (Oncorhyncus mykiss) hepatocytes were used to determine estrogenic effects. The PCBs 2,2',4,6,6'-pentachlorobiphenyl (104) and 2,2',3, 4', 5,6,6'-heptachlorobip …
A human breast cancer cell line (MCF-7) and primary cultures of rainbow trout (Oncorhyncus mykiss) hepatocytes were used to determine estrog …
Extracellular calcium is required for the polychlorinated biphenyl-induced increase of intracellular free calcium levels in cerebellar granule cell culture.
Mundy WR, Shafer TJ, Tilson HA, Kodavanti PR. Mundy WR, et al. Toxicology. 1999 Aug 13;136(1):27-39. doi: 10.1016/s0300-483x(99)00052-9. Toxicology. 1999. PMID: 10499848
The ortho-substituted congeners 2,2'-dichlorobiphenyl (DCB) and 2,2',4,6,6'-pentachlorobiphenyl (PeCB) caused a gradual increase of [Ca2+]i while the non-ortho-substituted congeners 4,4'-DCB and 3,3',4,4',5-PeCB had no effect. ...
The ortho-substituted congeners 2,2'-dichlorobiphenyl (DCB) and 2,2',4,6,6'-pentachlorobiphenyl (P …
17 results