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75 results

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Quoted phrase not found in phrase index: "2,2-dimethyl-4-butanol"
Page 1
The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice.
Wu K, Yuan Y, Yu H, Dai X, Wang S, Sun Z, Wang F, Fei H, Lin Q, Jiang H, Chen T. Wu K, et al. Blood. 2020 Jul 23;136(4):501-515. doi: 10.1182/blood.2019003990. Blood. 2020. PMID: 32291445 Free PMC article.
Either TMAO or a high-choline diet enhanced the allogenic GVH reaction, whereas the analog of choline, 3,3-dimethyl-1-butanol reversed TMAO-induced GVHD severity. Interestingly, TMAO-induced alloreactive T-cell proliferation and differentiation …
Either TMAO or a high-choline diet enhanced the allogenic GVH reaction, whereas the analog of choline, 3,3-dimethyl- …
Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.
Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL. Wang Z, et al. Cell. 2015 Dec 17;163(7):1585-95. doi: 10.1016/j.cell.2015.11.055. Cell. 2015. PMID: 26687352 Free PMC article.
Here, we investigate the impact of targeted inhibition of the first step in TMAO generation, commensal microbial TMA production, on diet-induced atherosclerosis. A structural analog of choline, 3,3-dimethyl-1-butanol (DMB), is shown to non-letha …
Here, we investigate the impact of targeted inhibition of the first step in TMAO generation, commensal microbial TMA production, on diet-ind …
Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia.
Wang J, Gao Y, Ren S, Li J, Chen S, Feng J, He B, Zhou Y, Xuan R. Wang J, et al. Gut Microbes. 2024 Jan-Dec;16(1):2311888. doi: 10.1080/19490976.2024.2311888. Epub 2024 Feb 13. Gut Microbes. 2024. PMID: 38351748 Free PMC article.
The results of the FMT experiment revealed that mice that received fecal microbiota transplantation from patients with PE developed typical PE symptoms and increased oxidative stress and inflammatory damage, both of which were reversed by 3,3-Dimethyl-1 …
The results of the FMT experiment revealed that mice that received fecal microbiota transplantation from patients with PE developed typical …
Intestinal IL-33 promotes microbiota-derived trimethylamine N -oxide synthesis and drives metabolic dysfunction-associated steatotic liver disease progression by exerting dual regulation on HIF-1α.
Hai S, Li X, Xie E, Wu W, Gao Q, Yu B, Hu J, Xu F, Zheng X, Zhang BH, Wu D, Yan W, Ning Q, Wang X. Hai S, et al. Hepatology. 2025 Jul 1;82(1):184-198. doi: 10.1097/HEP.0000000000000985. Epub 2024 Jul 10. Hepatology. 2025. PMID: 38985971 Free PMC article.
Inhibition of trimethylamine N -oxide synthesis by 3,3-dimethyl-1-butanol mitigated hepatic oxidative stress in mice with MASLD. Nuclear IL-33 bound to hypoxia-inducible factor-1alpha and suppressed its activation, directly damaging the integrit …
Inhibition of trimethylamine N -oxide synthesis by 3,3-dimethyl-1-butanol mitigated hepatic oxidative str …
Actions of some esters of 3,3-dimethylbutan-1-ol (the carbon analogue of choline) on the guinea-pig ileum.
Barlow RB, Tubby JH. Barlow RB, et al. Br J Pharmacol. 1974 May;51(1):95-100. doi: 10.1111/j.1476-5381.1974.tb09636.x. Br J Pharmacol. 1974. PMID: 4441798 Free PMC article.
1 Estimates were made of the affinity constants for postganglionic acetylcholine receptors of the guinea-pig ileum of the esters of 3,3-dimethylbutan-1-ol with benzilic, (+/-)-cyclohexylphenylglycollic, (+/-)-mandelic, and diphenylacetic acids.2 …
1 Estimates were made of the affinity constants for postganglionic acetylcholine receptors of the guinea-pig ileum of the esters of 3 …
3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice.
Wang G, Kong B, Shuai W, Fu H, Jiang X, Huang H. Wang G, et al. J Nutr Biochem. 2020 Apr;78:108341. doi: 10.1016/j.jnutbio.2020.108341. Epub 2020 Jan 9. J Nutr Biochem. 2020. PMID: 32004931
Trimethylamine N-oxide (TMAO) is closely related to cardiovascular diseases, particularly heart failure (HF). Recent studies shows that 3,3-dimethyl-1-butanol (DMB) can reduce plasma TMAO levels. However, the role of DMB in overload-induced HF i …
Trimethylamine N-oxide (TMAO) is closely related to cardiovascular diseases, particularly heart failure (HF). Recent studies shows that 3 …
Repeated 3,3-Dimethyl-1-butanol exposure alters social dominance in adult mice.
Mao J, Zhao P, Wang Q, Chen A, Li X, Li X, Liu T, Tao Z, Wang X, Du Y, Gong M, Song L, Gao Y, Shi H. Mao J, et al. Neurosci Lett. 2021 Jul 27;758:136006. doi: 10.1016/j.neulet.2021.136006. Epub 2021 Jun 9. Neurosci Lett. 2021. PMID: 34098029
Adult male mice were exposed to drinking water containing 3,3- Dimethyl-1-butanol (DMB), an indirect inhibitors of TMAO, for 21 continuous days followed by a series of behavioral tests to detect the effect of DMB exposure on social behaviors, ma …
Adult male mice were exposed to drinking water containing 3,3- Dimethyl-1-butanol (DMB), an indirect inhi …
TMAO promotes disorders of lipid metabolism in psoriasis.
Li R, Hu B, Mao M, Chen W, Zhu W. Li R, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025 Mar 28;50(3):331-343. doi: 10.11817/j.issn.1672-7347.2024.240663. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025. PMID: 40628502 Free PMC article.
To clarify the role of TMAO in the lipid metabolism disorder of mice with psoriasis model, exogenous TMAO, choline, or 3,3-dimethyl-1-butanol (DMB) were administered via intraperitoneal injections or diet in IMQ-treated mice. ...
To clarify the role of TMAO in the lipid metabolism disorder of mice with psoriasis model, exogenous TMAO, choline, or 3,3- …
3,3-dimethyl-1-butanol and its metabolite 3,3-dimethylbutyrate ameliorate collagen-induced arthritis independent of choline trimethylamine lyase activity.
Fechtner S, Allen BE, Chriswell ME, Jubair WK, Robertson CE, Kofonow JN, Frank DN, Holers VM, Kuhn KA. Fechtner S, et al. Res Sq [Preprint]. 2023 Sep 5:rs.3.rs-3297018. doi: 10.21203/rs.3.rs-3297018/v1. Res Sq. 2023. Update in: Inflammation. 2025 Jun;48(3):1350-1365. doi: 10.1007/s10753-024-02126-y. PMID: 37720032 Free PMC article. Updated. Preprint.
Therefore, we investigated the possibility of ameliorating CIA by inhibiting TMA lyase activity using 3,3-dimethyl-1-butanol (DMB) or fluoromethylcholine (FMC). During CIA, mice were treated with 1% vol/vol DMB, 100mg/kg FMC, or vehicle. ...
Therefore, we investigated the possibility of ameliorating CIA by inhibiting TMA lyase activity using 3,3-dimethyl-1 …
Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression.
Ge H, Wei Y, Zhang W, Yong C, Chen Y, Zhou E. Ge H, et al. Phytomedicine. 2024 Dec;135:156195. doi: 10.1016/j.phymed.2024.156195. Epub 2024 Oct 26. Phytomedicine. 2024. PMID: 39488871
In vivo, a adenine-induced CKD model was established, with or without a high-choline diet to observe the impact of TMAO on CKD, and SDG or 3,3-Dimethyl-1-butanol (DMB, a TMAO inhibitor) was used for intervention. The composition of gut microbiot …
In vivo, a adenine-induced CKD model was established, with or without a high-choline diet to observe the impact of TMAO on CKD, and SDG or …
75 results