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171 results

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2,3',4,4',5-Pentachlorobiphenyl induces mitochondria-dependent apoptosis mediated by AhR/Cyp1a1 in mouse germ cells.
Wang QY, Zhang L, Han XY, Wang DM, Ding ML, Cheng D, He QL, Liu SZ. Wang QY, et al. J Hazard Mater. 2023 Mar 5;445:130547. doi: 10.1016/j.jhazmat.2022.130547. Epub 2022 Dec 5. J Hazard Mater. 2023. PMID: 37055962
Polychlorinated biphenyls (PCBs) are environmental organic pollutants widely used in industry that can bioaccumulate and affect the reproductive systems of male animals of different species. 2,3',4,4',5-Pentachlorobiphenyl (PCB118) is a r …
Polychlorinated biphenyls (PCBs) are environmental organic pollutants widely used in industry that can bioaccumulate and affect the reproduc …
2,3',4,4',5-Pentachlorobiphenyl induced thyroid dysfunction by increasing mitochondrial oxidative stress.
Xu W, Zhu X, Wang L, Ding G, Wang X, Sheng Y, Lv S, Yu J, Liu J, Duan Y. Xu W, et al. J Toxicol Sci. 2022;47(12):555-565. doi: 10.2131/jts.47.555. J Toxicol Sci. 2022. PMID: 36450500 Free article.
Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) and are associated with thyroid diseases. Our previous study reported that 2,3',4,4',5-Pentachlorobiphenyl (PCB118) could induce thyroid dysfunction and the rat thy …
Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) and are associated with thyroid diseases. Our previous study repor …
2,3',4,4',5-Pentachlorobiphenyl induced autophagy of the thyrocytes via DAPK2/PKD/VPS34 pathway.
Zhou Q, Wang L, Chen H, Xu B, Xu W, Sheng Y, Duan Y. Zhou Q, et al. Arch Toxicol. 2019 Jun;93(6):1639-1648. doi: 10.1007/s00204-019-02458-x. Epub 2019 Apr 24. Arch Toxicol. 2019. PMID: 31020377
2,3',4,4',5-Pentachlorobiphenyl (PCB118) has been shown to cause thyroidal ultrastructure lesions, but the underlying mechanism remains elusive. ...
2,3',4,4',5-Pentachlorobiphenyl (PCB118) has been shown to cause thyroidal ultrastructure lesions,
2,3',4,4',5-Pentachlorobiphenyl Induced Thyrocyte Autophagy by Promoting Calcium Influx via Store-Operated Ca2+ Entry.
Wang L, Xu W, Zhou Q, Xu B, Sheng Y, Sun M, Chen H, Wang Y, Ding G, Duan Y. Wang L, et al. Toxicol Sci. 2020 Oct 1;177(2):483-493. doi: 10.1093/toxsci/kfaa116. Toxicol Sci. 2020. PMID: 32895711
PCB118, a 2,3',4,4',5-pentachlorobiphenyl, has been shown to destroy thyroidal ultrastructure and induce thyrocyte autophagy. ...
PCB118, a 2,3',4,4',5-pentachlorobiphenyl, has been shown to destroy thyroidal ultrastructure and …
2,3',4,4',5-Pentachlorobiphenyl attenuated fast-twitch fibers and fiber size of skeletal muscle via disturbing thyroid hormone signaling and mitochondrial dynamics.
Zhu X, Zou Y, Qi X, Sheng Y, Lv S, Yu J, Wang X, Ding G, Duan Y. Zhu X, et al. J Appl Toxicol. 2022 Oct;42(10):1628-1638. doi: 10.1002/jat.4330. Epub 2022 Apr 21. J Appl Toxicol. 2022. PMID: 35411558
It remains unclear how PCBs affect skeletal muscle (SM). In our study, wistar rats were injected 2,3',4,4',5-pentachlorobiphenyl (PCB118) intraperitoneally at 0, 10, 100, and 1000 mug/kg/day for 13 weeks, and C2C12 myoblasts were treated …
It remains unclear how PCBs affect skeletal muscle (SM). In our study, wistar rats were injected 2,3',4,4',5
2,3'4,4',5-Pentachlorobiphenyl induces hepatocellular carcinoma cell proliferation through pyruvate kinase M2-dependent glycolysis.
Liang W, Zhang Y, Song L, Li Z. Liang W, et al. Toxicol Lett. 2019 Oct 1;313:108-119. doi: 10.1016/j.toxlet.2019.06.006. Epub 2019 Jun 25. Toxicol Lett. 2019. PMID: 31251971
The present study investigated the effect of 2,3'4,4',5-pentachlorobiphenyl (PCB118) on hepatocellular carcinoma cell proliferation and its underlying mechanisms. ...
The present study investigated the effect of 2,3'4,4',5-pentachlorobiphenyl (PCB118) on hepatocell …
Intrauterine exposure to 2,3',4,4',5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice.
Tao YR, Zhang YT, Han XY, Zhang L, Jiang LG, Ma Y, Meng LJ, He QL, Liu SZ. Tao YR, et al. Ecotoxicol Environ Saf. 2021 Aug 27;224:112652. doi: 10.1016/j.ecoenv.2021.112652. Online ahead of print. Ecotoxicol Environ Saf. 2021. PMID: 34461319 Free article.
There are a total of 209 homologs, among which 2,3',4,4',5-pentachlorobiphenyl (PCB118) is one of the dioxin-like PCBs. PCB118 can accumulate in pregnant mice, leading to fetus directly exposure during development. ...
There are a total of 209 homologs, among which 2,3',4,4',5-pentachlorobiphenyl (PCB118) is one of …
Enhanced metabolism of 2,3',4,4',5-pentachlorobiphenyl (CB118) by bacterial cytochrome P450 monooxygenase mutants of Bacillus megaterium.
Ishida Y, Goto E, Haga Y, Kubo M, Itoh T, Kasai C, Tsuzuki H, Nakamura M, Shoji O, Yamamoto K, Matsumura C, Nakano T, Inui H. Ishida Y, et al. Sci Total Environ. 2023 Sep 10;890:164475. doi: 10.1016/j.scitotenv.2023.164475. Epub 2023 May 29. Sci Total Environ. 2023. PMID: 37257625
The wild type (WT) has been shown to metabolize the widely distributed polychlorinated biphenyl (PCB) 2,3',4,4',5-pentachlorobiphenyl (CB118) to hydroxylated metabolites. However, this reaction requires the coexistence of perfluoroalkyl c …
The wild type (WT) has been shown to metabolize the widely distributed polychlorinated biphenyl (PCB) 2,3',4,4', …
2,3',4,4',5-Pentachlorobiphenyl impairs insulin-induced NO production partly through excessive ROS production in endothelial cells.
Long Y, Huang C, Wu J, Cheng JN, Liang GN, Jiang CX, Wan Q. Long Y, et al. Toxicol Mech Methods. 2017 Oct;27(8):592-597. doi: 10.1080/15376516.2017.1337259. Epub 2017 Jul 14. Toxicol Mech Methods. 2017. PMID: 28592194
Polychlorinated biphenyls (PCBs) have been reported to be associated with increased risk to hypertension, atherosclerosis, cardiovascular disease, etc. 2,3',4,4',5-Pentachlorobiphenyl, known as PCB-118, is a member of coplanar PCBs which …
Polychlorinated biphenyls (PCBs) have been reported to be associated with increased risk to hypertension, atherosclerosis, cardiovascular di …
Effects of 2,3',4,4',5-pentachlorobiphenyl exposure during pregnancy on DNA methylation in the testis of offspring in the mouse.
Zhang JM, Wang QY, Han XY, He QL, Liu L, Zhang YT, Meng XQ, Cheng D, Zhang TL, Liu SZ. Zhang JM, et al. Reprod Fertil Dev. 2020 Aug;32(12):1048-1059. doi: 10.1071/RD19412. Reprod Fertil Dev. 2020. PMID: 32758352
This study experiment explored the effects of 2,3',4,4',5-pentachlorobiphenyl (PCB118) on the mammalian reproductive system. PCB118 was administered to pregnant mice from 7.5 to 12.5 days of gestation; F1 mice were obtained and the reprod …
This study experiment explored the effects of 2,3',4,4',5-pentachlorobiphenyl (PCB118) on the mamm …
171 results