PCB153 disrupts thyroid hormone homeostasis by affecting its biosynthesis, biotransformation, feedback regulation, and metabolism.
Liu C, Wang C, Yan M, Quan C, Zhou J, Yang K.
Liu C, et al.
Horm Metab Res. 2012 Sep;44(9):662-9. doi: 10.1055/s-0032-1311569. Epub 2012 Apr 19.
Horm Metab Res. 2012.
PMID: 22517553
Results showed that after treatment with PCB153, serum total thyroxine (TT4), total triiodothyronine (TT3), and thyrotropin releasing hormone (TRH) decreased, whereas serum thyroid stimulating hormone (TSH) concentration did not alter. ...Taken together, the …
Results showed that after treatment with PCB153, serum total thyroxine (TT4), total triiodothyronine (TT3), and thyrotropin releasing hor …