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689 results

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Quoted phrases not found in phrase index: "2,4,6-tribromodiphenyl ether", "steoroids"
Page 1
Effective Reprogramming of Patient-Derived M2-Polarized Glioblastoma-Associated Microglia/Macrophages by Treatment with GW2580.
Fermi V, Warta R, Wöllner A, Lotsch C, Jassowicz L, Rapp C, Knoll M, Jungwirth G, Jungk C, Dao Trong P, von Deimling A, Abdollahi A, Unterberg A, Herold-Mende C. Fermi V, et al. Clin Cancer Res. 2023 Nov 14;29(22):4685-4697. doi: 10.1158/1078-0432.CCR-23-0576. Clin Cancer Res. 2023. PMID: 37682326
Functional analyses included inducible nitric oxide synthase activity, phagocytosis, transmigration, and autologous tumor cell killing assays. Antitumor effects and changes in GAM activation were confirmed in a complex patient-derived 3D tumor organoid model serving …
Functional analyses included inducible nitric oxide synthase activity, phagocytosis, transmigration, and autologous tumor cell killin …
2,2',4,4'-Tetrabromodiphenyl ether exposure disrupts blood-testis barrier integrity through CMA-mediated ferroptosis.
Huang X, Fu Y, Wang S, Guo Q, Wu Y, Zheng X, Wang J, Wu S, Shen L, Wei G. Huang X, et al. Sci Total Environ. 2024 Oct 20;948:174738. doi: 10.1016/j.scitotenv.2024.174738. Epub 2024 Jul 14. Sci Total Environ. 2024. PMID: 39009145
2,2',4,4'-Tetrabromodiphenyl ether (PBDE-47), being the most prevalent congener of polybrominated diphenyl ethers (PBDEs), has been found to accumulate greatly in the environment and induce spermatogenesis dysfunction. ...These collective findin …
2,2',4,4'-Tetrabromodiphenyl ether (PBDE-47), being the most prevalent congener of polybrominated diphenyl ethers …
2,2',4,4'-Tetrabromodiphenyl ether disrupts spermatogenesis in mice by interfering with the ER-Nrf1-Tfam-mitochondria pathway.
Huang S, Xia J, Zhang X, Zhou T, Wang J, Liu T, Xu S, Liang G. Huang S, et al. Toxicol Ind Health. 2022 Mar;38(3):182-191. doi: 10.1177/07482337221081206. Epub 2022 Mar 3. Toxicol Ind Health. 2022. PMID: 35238255
2,2',4,4' -tetrabromodiphenyl ether (BDE47), a well-known endocrine disruptor of the estrogen receptor (ER) is toxic to the mitochondria and spermatogenesis. This study aimed to explore the mechanism of BDE47 on spermatogenesis in …
2,2',4,4' -tetrabromodiphenyl ether (BDE47), a well-known endocrine disruptor of the estrogen receptor (E …
Low level exposure to BDE-47 facilitates the development of prostate cancer through TOP2A/LDHA/lactylation positive feedback circuit.
Tian L, Zhou N, Zhao N, Qiao M, He M, Mao Z, Xu W, Xu D, Wang Y, Xu Y, Chen T. Tian L, et al. Environ Res. 2024 Dec 15;263(Pt 2):120094. doi: 10.1016/j.envres.2024.120094. Epub 2024 Oct 2. Environ Res. 2024. PMID: 39362459
2,2',4,4'-tetra brominated diphenyl ether (BDE-47) is one of the most widely distributed congeners of polybrominated diphenyl ethers. While the relationships between BDE-47 exposure and other hormone-dependent cancers (such as breast cancer …
2,2',4,4'-tetra brominated diphenyl ether (BDE-47) is one of the most widely distributed congeners of polybrominated di …
Human CYP enzyme-activated genotoxicity of 2,2',4,4'-tetrabromobiphenyl ether in mammalian cells.
Song M, Wang Y, Chen Z, Gao H, Yang Z, Yu H, Liu Y. Song M, et al. Chemosphere. 2022 Mar;291(Pt 1):132784. doi: 10.1016/j.chemosphere.2021.132784. Epub 2021 Nov 3. Chemosphere. 2022. PMID: 34742755
Polybrominated biphenyl ethers (PBDEs) are a group of persistent organic pollutants with endocrine-disrupting, neurotoxic, tumorigenic and DNA-damaging activities. They are hydroxylated by human liver microsomal CYP enzymes, however, their mutagenicity remains unkno …
Polybrominated biphenyl ethers (PBDEs) are a group of persistent organic pollutants with endocrine-disrupting, neurotoxic, tum …
Effects of 2,2',4,4'-tetrabromodiphenyl ether on the development of mouse embryonic stem cells.
Xu Q, Yu M, Zhou Y, Huang Z, Huang X, Xu B, Zhou K, Chen X, Xia Y, Wang X, Lu C, Han X. Xu Q, et al. Reprod Toxicol. 2021 Dec;106:18-24. doi: 10.1016/j.reprotox.2021.09.008. Epub 2021 Sep 20. Reprod Toxicol. 2021. PMID: 34547414
2,2',4,4'-Tetrabromodiphenyl ether (BDE47) poses potential risks to reproduction and development, but the mechanism of its toxicity has not yet been elucidated. ...
2,2',4,4'-Tetrabromodiphenyl ether (BDE47) poses potential risks to reproduction and development, but the mechanism of …
Modulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC.
Chen K, Li X, Dong S, Guo Y, Luo Z, Zhuang SM, Liu J, Liu T, Liao J, Wen W. Chen K, et al. J Transl Med. 2025 Jan 8;23(1):27. doi: 10.1186/s12967-024-06036-3. J Transl Med. 2025. PMID: 39780232 Free PMC article.
PURPOSE: Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor microenvironment (TME), exhibiting dual roles across various cancer types. Depending on the context, TAMs can either suppress tumor progression and weaken drug sensi …
PURPOSE: Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor microenvironment (TME), exhibiting dual …
Organophosphate Esters Disrupt Steroidogenesis in KGN Human Ovarian Granulosa Cells.
Wang X, Lee E, Hales BF, Robaire B. Wang X, et al. Endocrinology. 2023 Jun 6;164(7):bqad089. doi: 10.1210/endocr/bqad089. Endocrinology. 2023. PMID: 37288667 Free PMC article.
KGN cells were exposed for 48 hours to 1 of 5 OPEs (1-50muM): triphenyl phosphate (TPHP), tris(methylphenyl) phosphate (TMPP), isopropylated triphenyl phosphate (IPPP), tert-butylphenyl diphenyl phosphate (BPDP), and tributoxyethyl phosphate (TBOEP), or to a polybrominated diphen …
KGN cells were exposed for 48 hours to 1 of 5 OPEs (1-50muM): triphenyl phosphate (TPHP), tris(methylphenyl) phosphate (TMPP), isopropylated …
Protective effects of 2,4-dinitrophenol in okadaic acid-induced cellular model of Alzheimer's disease.
Cardoso S, Carvalho C, Correia SC, Moreira PI. Cardoso S, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Aug;1870(6):167222. doi: 10.1016/j.bbadis.2024.167222. Epub 2024 May 8. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38729530 Free article.
In this perspective, the present study was aimed to investigate the possible beneficial effects of 2,4 dinitrophenol (DNP), a mitochondrial uncoupler agent, in an in vitro model of AD. ...
In this perspective, the present study was aimed to investigate the possible beneficial effects of 2,4 dinitrophenol (DNP), a …
Perinatal exposure to 2,2',4'4' -Tetrabromodiphenyl ether induces testicular toxicity in adult rats.
Khalil A, Parker M, Brown SE, Cevik SE, Guo LW, Jensen J, Olmsted A, Portman D, Wu H, Suvorov A. Khalil A, et al. Toxicology. 2017 Aug 15;389:21-30. doi: 10.1016/j.tox.2017.07.006. Epub 2017 Jul 13. Toxicology. 2017. PMID: 28712647
Since 1965, polybrominated diphenyl ethers (PBDEs) have been used internationally as flame-retardant additives. PBDEs were recently withdrawn from commerce in North America and Europe due to their environmental persistence, bioaccumulative properties and endocrine-d …
Since 1965, polybrominated diphenyl ethers (PBDEs) have been used internationally as flame-retardant additives. PBDEs were recently w …
689 results