Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
Fukushima T, Yoshihara H, Furuta H, Kamei H, Hakuno F, Luan J, Duan C, Saeki Y, Tanaka K, Iemura S, Natsume T, Chida K, Nakatsu Y, Kamata H, Asano T, Takahashi S.
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Nat Commun. 2015 Apr 16;6:6780. doi: 10.1038/ncomms7780.
Nat Commun. 2015.
PMID: 25879670
Free article.
Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. ...The Ne …
Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer d …