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Page 1
Enantioselective Total Synthesis of (+)-Eucophylline.
Traboulsi I, Dange NS, Pirenne V, Robert F, Landais Y. Traboulsi I, et al. Chemistry. 2022 Mar 16;28(16):e202200088. doi: 10.1002/chem.202200088. Epub 2022 Feb 21. Chemistry. 2022. PMID: 35084786
Further elaboration of the latter into the key 1-azabicyclo[3.3.1]nonane motif followed by its coupling with a 2-cyanoaniline allowed the formation of the tetrahydrobenzo[b][1,8]-naphthyridine skeleton of 1, which was finally accessible in 17 steps and 5.9 % overall …
Further elaboration of the latter into the key 1-azabicyclo[3.3.1]nonane motif followed by its coupling with a 2-cyanoaniline …
Room temperature ligand-free Cu2O-H2O2 catalyzed tandem oxidative synthesis of quinazoline-4(3H)-one and quinazoline derivatives.
Dutta N, Dutta B, Dutta A, Sarma B, Sarma D. Dutta N, et al. Org Biomol Chem. 2023 Jan 25;21(4):748-753. doi: 10.1039/d2ob02085h. Org Biomol Chem. 2023. PMID: 36602007
An efficient and simple copper catalytic system has been developed for the synthesis of medicinally important 2-substituted quinazoline-4(3H)-ones from 2-aminobenzonitrile and benzyl alcohol derivatives and additionally 2-substituted quinazolines from 2-aminobenzyla …
An efficient and simple copper catalytic system has been developed for the synthesis of medicinally important 2-substituted quinazoline-4(3H …
Multicomponent Polymerizations of Alkynes, Sulfonyl Azides, and 2-Hydroxybenzonitrile/2-Aminobenzonitrile toward Multifunctional Iminocoumarin/Quinoline-Containing Poly(N-sulfonylimine)s.
Xu L, Zhou T, Liao M, Hu R, Tang BZ. Xu L, et al. ACS Macro Lett. 2019 Feb 19;8(2):101-106. doi: 10.1021/acsmacrolett.8b00884. Epub 2019 Jan 9. ACS Macro Lett. 2019. PMID: 35619415
In this work, the MCPs of diynes, disulfonyl azides, and 2-hydroxybenzonitrile or 2-aminobenzonitrile were reported under the catalysis of CuCl and Et(3)N, generating iminocoumarin/quinoline-containing poly(N-sulfonylimine)s with high molecular weights (up to 37700 …
In this work, the MCPs of diynes, disulfonyl azides, and 2-hydroxybenzonitrile or 2-aminobenzonitrile were reported under the …
Polyphosphoric Acid Esters Promoted Synthesis of Quinazolin-4(3H)-imines from 2-Aminobenzonitrile.
Kilimciler NB, Palavecino NM, Gruber N, Vega DR, Orelli LR, Díaz JE. Kilimciler NB, et al. J Org Chem. 2024 Oct 4;89(19):13807-13817. doi: 10.1021/acs.joc.2c02558. Epub 2023 Mar 15. J Org Chem. 2024. PMID: 36919225
A novel method for the synthesis of quinazolin-4(3H)-imines (QIs) by trimethylsilyl polyphosphate (PPSE) promoted reaction of 2-aminobenzonitrile with secondary amides is reported. The reaction is general and allows for the synthesis of N(3)-aryl and N(3)-alkyl QIs …
A novel method for the synthesis of quinazolin-4(3H)-imines (QIs) by trimethylsilyl polyphosphate (PPSE) promoted reaction of 2-am …
Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(p-Cymene)Cl2L] and Their Cytotoxicity against HeLa-Type Cancer Cells.
Fuster MG, Moulefera I, Montalbán MG, Pérez J, Víllora G, García G. Fuster MG, et al. Molecules. 2022 Oct 26;27(21):7264. doi: 10.3390/molecules27217264. Molecules. 2022. PMID: 36364091 Free PMC article.
When the [Ru(p-cymene)(mu-Cl)Cl](2) complex is made to react, in dichloromethane, with the following ligands: 2-aminobenzonitrile (2abn), 4-aminobenzonitrile (4abn), 2-aminopyridine (2ampy) and 4-aminopyridine (4ampy), after addition of hexane, the following compoun …
When the [Ru(p-cymene)(mu-Cl)Cl](2) complex is made to react, in dichloromethane, with the following ligands: 2-aminobenzonitrile …
Synthesis, evaluation and structure-activity relationships of 5-alkyl-2,3-dihydroimidazo[1,2-c] quinazoline, 2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-thiones and their oxo-analogues as new potential bronchodilators.
Bahekar RH, Rao AR. Bahekar RH, et al. Arzneimittelforschung. 2001;51(4):284-92. doi: 10.1055/s-0031-1300039. Arzneimittelforschung. 2001. PMID: 11367868
The former (Method A) based on the dehydrocyclization of 4-(1-hydroxyethyl)-aminoquinazoline (IV) and the latter (Method B) involves the usage of 2-aminobenzonitrile (VI) which on reaction with ethylenediamine leads to the formation of the key intermediate 2-(2-amin …
The former (Method A) based on the dehydrocyclization of 4-(1-hydroxyethyl)-aminoquinazoline (IV) and the latter (Method B) involves the usa …
Delineating the Mechanism of Ionic Liquids in the Synthesis of Quinazoline-2,4(1H,3H)-dione from 2-Aminobenzonitrile and CO(2).
Hulla M, Chamam SMA, Laurenczy G, Das S, Dyson PJ. Hulla M, et al. Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10559-10563. doi: 10.1002/anie.201705438. Epub 2017 Jul 26. Angew Chem Int Ed Engl. 2017. PMID: 28678430
Ionic liquids (ILs) are versatile solvents and catalysts for the synthesis of quinazoline-2,4-dione from 2-aminobenzonitrile and CO(2) . However, the role of the IL in this reaction is poorly understood. ...
Ionic liquids (ILs) are versatile solvents and catalysts for the synthesis of quinazoline-2,4-dione from 2-aminobenzonitrile a …
Harnessing the benzyne insertion consequence to enable π-extended pyrido-acridine and quinazolino-phenanthridine.
Ghosh S, Das D, Mandal RD, Das AR. Ghosh S, et al. Org Biomol Chem. 2024 Jul 10;22(27):5591-5602. doi: 10.1039/d4ob00533c. Org Biomol Chem. 2024. PMID: 38898782
Interestingly, the parent compounds (acridines and quinazolimines) are actualized from 2-aminobenzonitrile and anthranilic acid, where 2-aminobenzonitrile acts as the 1,4-dipolarophilic species and anthranilic acid as the benzyne precursor. ...
Interestingly, the parent compounds (acridines and quinazolimines) are actualized from 2-aminobenzonitrile and anthranilic aci …
26 results