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Quoted phrases not found in phrase index: "2-biphenylcarboxylic acid", "2-phenylbenzoic acid", "o-phenylbenzoic acid"
Page 1
Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPARgamma agonists.
Obermoser V, Mauersberger R, Schuster D, Czifersky M, Lipova M, Siegl M, Kintscher U, Gust R. Obermoser V, et al. Eur J Med Chem. 2017 Jan 27;126:590-603. doi: 10.1016/j.ejmech.2016.11.051. Epub 2016 Nov 25. Eur J Med Chem. 2017. PMID: 27918994
In this structure-activity relationship study, the influence of aryl substituents at position 5 or 6 on the pharmacological profile of the partial PPARgamma agonist 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic a …
In this structure-activity relationship study, the influence of aryl substituents at position 5 or 6 on the pharmacological profile of the p …
Biphenyl-2-carboxylic acid: a layered structure.
Dobson AJ, Gerkin RE. Dobson AJ, et al. Acta Crystallogr C. 1998 Jun 15;54 ( Pt 6):795-8. doi: 10.1107/s0108270197018738. Acta Crystallogr C. 1998. PMID: 9675843
New telmisartan-derived PPARγ agonists: Impact of the 3D-binding mode on the pharmacological profile.
Obermoser V, Urban ME, Murgueitio MS, Wolber G, Kintscher U, Gust R. Obermoser V, et al. Eur J Med Chem. 2016 Nov 29;124:138-152. doi: 10.1016/j.ejmech.2016.08.027. Epub 2016 Aug 15. Eur J Med Chem. 2016. PMID: 27569195
In previous studies, the 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid was identified as pharmacophoric core for PPARgamma activation. ...
In previous studies, the 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic a …
Synthesis of Polycyclic Cyclohexadienone through Alkoxy-Oxylactonization and Dearomatization of 3'-Hydroxy-[1,1'-biphenyl]-2-carboxylic Acids Promoted by Hypervalent Iodine.
Deng Q, Xia W, Hussain MI, Zhang X, Hu W, Xiong Y. Deng Q, et al. J Org Chem. 2020 Mar 6;85(5):3125-3133. doi: 10.1021/acs.joc.9b03012. Epub 2020 Jan 27. J Org Chem. 2020. PMID: 31942790
Alkox-oxylactonization and dearomatization of 3'-hydroxy-[1,1'-biphenyl]-2-carboxylic acid simultaneously promoted by hypervalent iodine have been developed using stoichiometric PhI(OAc)(2) or a catalytic amount of chiral aryl-lambda(3)-i …
Alkox-oxylactonization and dearomatization of 3'-hydroxy-[1,1'-biphenyl]-2-carboxylic acid simulta …
Angiotensin II receptor antagonists.
van Meel JC, Entzeroth M, Hauel N, Narr B, Ries U, Wienen W. van Meel JC, et al. Arzneimittelforschung. 1993 Feb;43(2A):242-6. Arzneimittelforschung. 1993. PMID: 8498971 Review.
So far, non-selective non-peptide Ang II receptor antagonists have not been identified although AT1/AT2 selectivity ratios of 17 and 37 have already been reported for BIBS 39 (4'-[(2-n-butyl-6- cyclohexylaminocarbonylamino-benzimidazole-1-yl)-methyl] biphenyl-2-c …
So far, non-selective non-peptide Ang II receptor antagonists have not been identified although AT1/AT2 selectivity ratios of 17 and 37 have …
An Effective Synthesis Method for Tilorone Dihydrochloride with Obvious IFN-α Inducing Activity.
Zhang J, Yao Q, Liu Z. Zhang J, et al. Molecules. 2015 Dec 2;20(12):21458-63. doi: 10.3390/molecules201219781. Molecules. 2015. PMID: 26633340 Free PMC article.
In the novel method, methyl esterification of 4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylic acid (4) was carried out under milder conditions with higher yield and played an important role in the preparation of compound 2. ...
In the novel method, methyl esterification of 4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylic acid (4) …
Pharmacological repression of PPARγ promotes osteogenesis.
Marciano DP, Kuruvilla DS, Boregowda SV, Asteian A, Hughes TS, Garcia-Ordonez R, Corzo CA, Khan TM, Novick SJ, Park H, Kojetin DJ, Phinney DG, Bruning JB, Kamenecka TM, Griffin PR. Marciano DP, et al. Nat Commun. 2015 Jun 12;6:7443. doi: 10.1038/ncomms8443. Nat Commun. 2015. PMID: 26068133 Free PMC article.
Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells.
Schoepf AM, Salcher S, Obexer P, Gust R. Schoepf AM, et al. Eur J Med Chem. 2020 Jun 1;195:112258. doi: 10.1016/j.ejmech.2020.112258. Epub 2020 Mar 26. Eur J Med Chem. 2020. PMID: 32272420
4'-((2-Propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived from telmisartan was identified as lead for the design of cell death modulators. ...
4'-((2-Propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived from telm …
Synthesis and Characterization of Telmisartan-Derived Cell Death Modulators to Circumvent Imatinib Resistance in Chronic Myeloid Leukemia.
Schoepf AM, Salcher S, Hohn V, Veider F, Obexer P, Gust R. Schoepf AM, et al. ChemMedChem. 2020 Jun 17;15(12):1067-1077. doi: 10.1002/cmdc.202000092. Epub 2020 May 6. ChemMedChem. 2020. PMID: 32298535 Free PMC article.
Here, the importance of the heterocyclic core on the cell death-modulating effects of the telmisartan-derived lead 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid (3 b) was investigated. Inspired by the ph …
Here, the importance of the heterocyclic core on the cell death-modulating effects of the telmisartan-derived lead 4'-((2-propyl-1H-benzo[d] …
48 results