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3-Amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carbonitrile.
Zeng XX, Ye TH, Lun DW, Yu LT, Yang L. Zeng XX, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 21;65(Pt 12):o3138. doi: 10.1107/S1600536809048132. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21578859 Free PMC article.
CO(2) Conversion with Alcohols and Amines into Carbonates, Ureas, and Carbamates over CeO(2) Catalyst in the Presence and Absence of 2-Cyanopyridine.
Tomishige K, Tamura M, Nakagawa Y. Tomishige K, et al. Chem Rec. 2019 Jul;19(7):1354-1379. doi: 10.1002/tcr.201800117. Epub 2018 Oct 31. Chem Rec. 2019. PMID: 30378755 Review.
One of the effective method of the H(2) O removal from the related reaction systems is the combination with the hydration of 2-cyanopyridine to 2-picolinamide, which is also catalyzed by CeO(2) ....
One of the effective method of the H(2) O removal from the related reaction systems is the combination with the hydration of 2-cya
Comparative Study between 2-Furonitrile and 2-Cyanopyridine as Dehydrants in Direct Synthesis of Dialkyl Carbonates from CO(2) and Alcohols over Cerium Oxide Catalyst.
Sun W, Li P, Yabushita M, Nakagawa Y, Wang Y, Nakayama A, Tomishige K. Sun W, et al. ChemSusChem. 2023 Dec 19;16(24):e202300768. doi: 10.1002/cssc.202300768. Epub 2023 Oct 5. ChemSusChem. 2023. PMID: 37639290
Herein, the performance of 2-cyanopyridine and 2-furonitrile was compared in the synthesis of various dialkyl carbonates. 2-furonitrile was found to be superior to 2-cyanopyridine in the synthesis of dialkyl carbonates from CO(2) and bulky or long-chai …
Herein, the performance of 2-cyanopyridine and 2-furonitrile was compared in the synthesis of various dialkyl carbonates. 2-fu …
Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: a chemical model to describe the formation of thiazoline derivatives in human liver microsomes.
Sinha S, Ahire D, Wagh S, Mullick D, Sistla R, Selvakumar K, Cortes JC, Putlur SP, Mandlekar S, Johnson BM. Sinha S, et al. Chem Res Toxicol. 2014 Dec 15;27(12):2052-61. doi: 10.1021/tx500256j. Epub 2014 Dec 2. Chem Res Toxicol. 2014. PMID: 25372409
In the present study, the intrinsic reactivity and associated structure-property relationships of cathepsin K inhibitors featuring substituted pyridazines [6-phenylpyridazine-3-carbonitrile, 6-(4-fluorophenyl)pyridazine-3-carbonitrile, 6-(4-methoxyphenyl)pyridazine-3-carbonitrile …
In the present study, the intrinsic reactivity and associated structure-property relationships of cathepsin K inhibitors featuring substitut …
A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation.
Formenti D, Mocci R, Atia H, Dastgir S, Anwar M, Bachmann S, Scalone M, Junge K, Beller M. Formenti D, et al. Chemistry. 2020 Dec 1;26(67):15589-15595. doi: 10.1002/chem.202001866. Epub 2020 Sep 24. Chemistry. 2020. PMID: 32337746
The advantage of this novel catalytic material is showcased for industrially important substrates, including adipodinitrile, picolinonitrile, and fatty acid nitriles. Notably, the developed system outperformed all other tested commercial catalysts, for example, Raney Nicke …
The advantage of this novel catalytic material is showcased for industrially important substrates, including adipodinitrile, picolinonitr
Photodegradation of 2-chloropyridine in aqueous solution: Reaction pathways and genotoxicity of intermediate products.
Skoutelis C, Antonopoulou M, Konstantinou I, Vlastos D, Papadaki M. Skoutelis C, et al. J Hazard Mater. 2017 Jan 5;321:753-763. doi: 10.1016/j.jhazmat.2016.09.058. Epub 2016 Sep 24. J Hazard Mater. 2017. PMID: 27726902
., 1H-pyrrole-2-carboxaldehyde, 6-chloro-2-pyridinecarboxylic acid, 2,3-dichloropyridine and 2-pyridinecarbonitrile was measured; the obtained results were used for the reasoning on the variation of the solution genotoxic (including clastogenic as well as aneugenic) …
., 1H-pyrrole-2-carboxaldehyde, 6-chloro-2-pyridinecarboxylic acid, 2,3-dichloropyridine and 2-pyridinecarbonitrile was measur …
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies.
Tong L, Song P, Jiang K, Xu L, Jin T, Wang P, Hu X, Fang S, Gao A, Zhou Y, Liu T, Li J, Hu Y. Tong L, et al. Eur J Med Chem. 2019 Jul 1;173:44-62. doi: 10.1016/j.ejmech.2019.03.062. Epub 2019 Apr 3. Eur J Med Chem. 2019. PMID: 30986571
Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of 5-(pyrimidin-2-ylamino)picolinonitrile derivatives as CHK1 inhibitors were discovered by further rational optimization. ...
Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of 5-(pyr …
Formation of a New, Strongly Basic Nitrogen Anion by Metal Oxide Modification.
Tamura M, Kishi R, Nakayama A, Nakagawa Y, Hasegawa JY, Tomishige K. Tamura M, et al. J Am Chem Soc. 2017 Aug 30;139(34):11857-11867. doi: 10.1021/jacs.7b05227. Epub 2017 Aug 17. J Am Chem Soc. 2017. PMID: 28753288
It is based on the modification of organic compounds with metal oxides by using the acid-base property of metal oxides. Based on kinetic and DFT studies, combination of CeO(2) and 2-cyanopyridine drastically enhanced the basicity of 2-cyanopyridine by …
It is based on the modification of organic compounds with metal oxides by using the acid-base property of metal oxides. Based on kinetic and …
Fungal nitrilases as biocatalysts: Recent developments.
Martínková L, Vejvoda V, Kaplan O, Kubáč D, Malandra A, Cantarella M, Bezouška K, Křen V. Martínková L, et al. Biotechnol Adv. 2009 Nov-Dec;27(6):661-670. doi: 10.1016/j.biotechadv.2009.04.027. Epub 2009 May 7. Biotechnol Adv. 2009. PMID: 19427375 Review.
The production of fungal nitrilases is increased by up to three orders of magnitude on the addition of 2-cyanopyridine to the culture media. The whole-cell and subcellular biocatalysts were immobilized by various methods (LentiKats(R); adsorption on hydrophobic or i …
The production of fungal nitrilases is increased by up to three orders of magnitude on the addition of 2-cyanopyridine to the …
68 results