Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1966 1
1968 1
1969 1
1972 1
1985 1
1986 1
1987 1
1988 1
1989 1
1990 2
1993 2
1994 4
1995 2
1996 2
1997 3
1998 4
1999 2
2001 3
2002 2
2003 2
2004 5
2005 6
2006 3
2007 2
2008 1
2009 5
2010 10
2011 6
2012 3
2013 3
2014 6
2015 1
2016 4
2017 3
2018 1
2019 5
2020 1
2021 5
2022 1
2024 2
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

104 results

Results by year

Filters applied: . Clear all
Quoted phrases not found in phrase index: "2-hydroxy-2-methylpropanenitrile", "a-hydroxyisobutyronitrile", "aceton cyanohydrin", "isopropyl cyanohydrin", "oxyisobutyric nitrile"
Page 1
Catalysis for the synthesis of methacrylic acid and methyl methacrylate.
Darabi Mahboub MJ , Dubois JL , Cavani F , Rostamizadeh M , Patience GS . Darabi Mahboub MJ , et al. Chem Soc Rev. 2018 Oct 15;47(20):7703-7738. doi: 10.1039/c8cs00117k. Chem Soc Rev. 2018. PMID: 30211916 Review.
The dominant commercial process reacts acetone and hydrogen cyanide to MMA (ACH route) but the intermediates (hydrogen cyanide, and acetone cyanohydrin) are toxic and represent an environmental hazard. Esterification of methacrylic acid (MAA) to MMA is a compelling …
The dominant commercial process reacts acetone and hydrogen cyanide to MMA (ACH route) but the intermediates (hydrogen cyanide, and aceto …
Ligand-Enabled Gold-Catalyzed Cyanation of Organohalides.
Kumar A, Bhattacharya N, Mane MV, Patil NT. Kumar A, et al. Angew Chem Int Ed Engl. 2024 Nov 18;63(47):e202412682. doi: 10.1002/anie.202412682. Epub 2024 Oct 14. Angew Chem Int Ed Engl. 2024. PMID: 39129346
Herein, we disclose the first report on gold-catalyzed C(sp(2))-CN cross-coupling reaction by employing a ligand-enabled Au(I)/Au(III) redox catalysis. This transformation utilizes acetone cyanohydrin as a nucleophilic cyanide source to convert simple aryl and alken …
Herein, we disclose the first report on gold-catalyzed C(sp(2))-CN cross-coupling reaction by employing a ligand-enabled Au(I)/Au(III) redox …
A fatal poisoning case of acetone cyanohydrin and citalopram.
Nishio T, Toukairin Y, Hoshi T, Arai T, Nogami M. Nishio T, et al. Leg Med (Tokyo). 2021 Nov;53:101937. doi: 10.1016/j.legalmed.2021.101937. Epub 2021 Jun 26. Leg Med (Tokyo). 2021. PMID: 34233261
Acetone cyanohydrin (ACH) is a readily available source of cyanide and is widely used in basic and applied sciences. ...
Acetone cyanohydrin (ACH) is a readily available source of cyanide and is widely used in basic and applied sciences. ...
Evolution of a Catalytic Mechanism.
Rauwerdink A, Lunzer M, Devamani T, Jones B, Mooney J, Zhang ZJ, Xu JH, Kazlauskas RJ, Dean AM. Rauwerdink A, et al. Mol Biol Evol. 2016 Apr;33(4):971-9. doi: 10.1093/molbev/msv338. Epub 2015 Dec 16. Mol Biol Evol. 2016. PMID: 26681154 Free PMC article.
We argue that the catalytic mechanisms of plant esterases and descendent acetone cyanohydrin lyases are incompatible with each other (e.g., the reactive substrate carbonyl must bind in opposite orientations in the active site). We then show that resurrected ancestra …
We argue that the catalytic mechanisms of plant esterases and descendent acetone cyanohydrin lyases are incompatible with each …
Two fatal cases of acetone cyanohydrin poisoning: case report and literature review.
Cao Z, Guan D, Wu X. Cao Z, et al. Forensic Sci Med Pathol. 2021 Dec;17(4):700-705. doi: 10.1007/s12024-021-00425-6. Epub 2021 Oct 19. Forensic Sci Med Pathol. 2021. PMID: 34665394 Review.
Acetone cyanohydrin (ACH), an organic cyanide, is mainly used in the production of methyl methacrylate (MMA), and it also exists in cassava roots, the main calorie source in some tropical countries. ...
Acetone cyanohydrin (ACH), an organic cyanide, is mainly used in the production of methyl methacrylate (MMA), and it also exis …
Structural characterization of Linum usitatissimum hydroxynitrile lyase: A new cyanohydrin decomposition mechanism involving a cyano-zinc complex.
Zheng D, Nakabayashi M, Asano Y. Zheng D, et al. J Biol Chem. 2022 Mar;298(3):101650. doi: 10.1016/j.jbc.2022.101650. Epub 2022 Jan 29. J Biol Chem. 2022. PMID: 35101448 Free PMC article.
Herein, we determined the ligand-free 3D structure of LuHNL and its complex with acetone cyanohydrin and (R)-2-butanone cyanohydrin using X-ray crystallography. These structures reveal that an A-form NAD(+) is tightly but not covalently bound to each subunit of LuHN …
Herein, we determined the ligand-free 3D structure of LuHNL and its complex with acetone cyanohydrin and (R)-2-butanone cyanoh …
Programmed Formation of HCN Oligomers through Organosulfur Catalysis.
Grundke C, Kong C, Kampf CJ, Gupton BF, McQuade DT, Opatz T. Grundke C, et al. J Org Chem. 2021 Aug 6;86(15):10320-10329. doi: 10.1021/acs.joc.1c01023. Epub 2021 Jul 12. J Org Chem. 2021. PMID: 34251206
An efficient, inexpensive, and reliable synthesis of diaminomaleonitrile (DAMN, 1) is described starting from readily available acetone cyanohydrin as the source of hydrogen cyanide (HCN). Diaminomaleonitrile (DAMN) is known to be an important intermediate in hetero …
An efficient, inexpensive, and reliable synthesis of diaminomaleonitrile (DAMN, 1) is described starting from readily available acetone …
Catalytic Hydrocyanation of Activated Terminal Alkynes.
Tejedor D, Delgado-Hernández S, Colella L, García-Tellado F. Tejedor D, et al. Chemistry. 2019 Nov 27;25(66):15046-15049. doi: 10.1002/chem.201903402. Epub 2019 Nov 11. Chemistry. 2019. PMID: 31553088
The catalytic manifold operates under the reactivity generation principle "a good nucleophile generates a strong base", and it uses 1,4-diazabicyclo[2.2.2]octane (DABCO) as the catalyst, activated terminal alkynes as substrates and acetone cyanohydrin as the cyanide …
The catalytic manifold operates under the reactivity generation principle "a good nucleophile generates a strong base", and it uses 1,4-diaz …
The targets of acetone cyanohydrin neurotoxicity in the rat are not the ones expected in an animal model of konzo.
Soler-Martín C, Riera J, Seoane A, Cutillas B, Ambrosio S, Boadas-Vaello P, Llorens J. Soler-Martín C, et al. Neurotoxicol Teratol. 2010 Mar-Apr;32(2):289-94. doi: 10.1016/j.ntt.2009.11.001. Epub 2009 Nov 20. Neurotoxicol Teratol. 2010. PMID: 19932169
After this period, rats were fasted for 24h in order to increase endogenous acetone synthesis, and then exposed to 0 (control group) or 50 micromol/kg-h of acetone cyanohydrin for 24h (treated group) through subcutaneous osmotic minipump infusion (n=6/group). ...Sim …
After this period, rats were fasted for 24h in order to increase endogenous acetone synthesis, and then exposed to 0 (control group) or 50 m …
Contribution of hippocampal area CA1 to acetone cyanohydrin-induced loss of motor coordination in rats.
Rivadeneyra-Domínguez E, Vázquez-Luna A, Díaz-Sobac R, Briones-Céspedes EE, Rodríguez-Landa JF. Rivadeneyra-Domínguez E, et al. Neurologia. 2017 May;32(4):230-235. doi: 10.1016/j.nrl.2015.11.010. Epub 2016 Jan 13. Neurologia. 2017. PMID: 26774413 Free article. English, Spanish.
On the fifth day post-treatment, rats underwent further assessment with behavioural tests to identify or rule out permanent damage induced by acetone cyanohydrin. RESULTS: Microinjection of acetone cyanohydrin 20mM resulted in hyperactivity, motor impa …
On the fifth day post-treatment, rats underwent further assessment with behavioural tests to identify or rule out permanent damage induced b …
104 results