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Quoted phrase not found in phrase index: "steoroids"
Page 1
Explorations of ATP-Binding Cassette Transporters and Apoptosis Signal Pathways of 2-Hydroxyanthraquinone Substituted Cyclotriphosphazenes in MCF-7 and DLD-1 Cell Lines.
Yazgan B, Mesci S, Bayık N, Akşahin M, Çiftçi GY, Yıldırım T. Yazgan B, et al. Anticancer Agents Med Chem. 2022;22(6):1124-1138. doi: 10.2174/1871520621666210805144252. Anticancer Agents Med Chem. 2022. PMID: 34353271
BACKGROUND: As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various physical effects, phosphazene derivatives constitute the most striking part of inorganic compounds. ...RESULTS: Compounds 2, 3, 4, and 7 showed the most potent res …
BACKGROUND: As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various physical effects, phosp …
Effects of Alkoxy Chain Length and 1-Hydroxy Group on Anticolorectal Cancer Activity of 2-Bromoalkoxyanthraquinones.
Mekzali NW, Chee CW, Abdullah I, Lee YK, Rashid NN, Lee VS, Othman R, Hashim NM, Chee CF. Mekzali NW, et al. Med Chem. 2023;19(9):897-905. doi: 10.2174/1573406419666230410134213. Med Chem. 2023. PMID: 37046198
BACKGROUND: KRAS and p53 are two of the most common genetic alterations associated with colorectal cancer. New drug development targeting these mutated genes in colorectal cancer may serve as a potential treatment avenue to the current regimen. ...CONCLUSION: This w …
BACKGROUND: KRAS and p53 are two of the most common genetic alterations associated with colorectal cancer. New drug development targe …
In Silico Molecular Docking of 2-Hydroxyanthraquinone-Substituted Spiro-/Ansa Cyclotriphosphazenes: Targeting Apoptosis via Heat Shock Protein Modulation in Breast and Colon Cancer Cells.
Mesci S, Yazgan B, Demir Demirel G, Yildirim T, Yenilmez Çiftçi G. Mesci S, et al. Biotechnol Appl Biochem. 2025 Dec;72(6):1618-1632. doi: 10.1002/bab.2767. Epub 2025 Apr 29. Biotechnol Appl Biochem. 2025. PMID: 40296721
Cancer research takes a long time and is complex. Preclinical studies prove that compounds can be potential anticancer agents and contribute to cancer studies. ...In this study, it was aimed to investigate the effect of 2-hydroxyanthraquinone-substitut …
Cancer research takes a long time and is complex. Preclinical studies prove that compounds can be potential anticancer agents and con …
Colitis-related rat colon carcinogenesis induced by 1-hydroxy-anthraquinone and methylazoxymethanol acetate (Review).
Tanaka T, Kohno H, Murakami M, Shimada R, Kagami S. Tanaka T, et al. Oncol Rep. 2000 May-Jun;7(3):501-8. doi: 10.3892/or.7.3.501. Oncol Rep. 2000. PMID: 10767359 Review.
Patients with long-standing ulcerative colitis (UC) have an increased risk for developing colorectal cancer (CRC) compared to the general population. For investigation of the mechanisms and prevention of UC and UC-related CRC, establishment of a promising animal model for …
Patients with long-standing ulcerative colitis (UC) have an increased risk for developing colorectal cancer (CRC) compared to the gen …
Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs.
Meng QX, Roubin RH, Hanrahan JR. Meng QX, et al. J Ethnopharmacol. 2013 Jun 21;148(1):229-38. doi: 10.1016/j.jep.2013.04.014. Epub 2013 Apr 23. J Ethnopharmacol. 2013. PMID: 23623820
One new compound, ethyl 13(2) (S)-hydroxy-chlorophyllide a(1), along with 10 known compounds, i.e. 2-methyl-3-methoxyanthraquinone (2), 2-hydroxymethylanthraquinone(3), 2-hydroxy-3-methylanthraquinone(4), 2-hydroxymethy-1-hydroxyanthraquinone(5), 1-methoxy-2-hydroxyanth …
One new compound, ethyl 13(2) (S)-hydroxy-chlorophyllide a(1), along with 10 known compounds, i.e. 2-methyl-3-methoxyanthraquinone (2), 2-hy …
Apoptosis-inducing effects of two anthraquinones from Hedyotis diffusa WILLD.
Shi Y, Wang CH, Gong XG. Shi Y, et al. Biol Pharm Bull. 2008 Jun;31(6):1075-8. doi: 10.1248/bpb.31.1075. Biol Pharm Bull. 2008. PMID: 18520033 Free article.
Two anthraquinones which inhibit activity of the Src tyrosine kinase were isolated from a water extract of Hedyotis diffusa WILLD. and identified as 2-hydroxy-3-methylanthraquinone (compound 1) and 1-methoxy-2-hydroxyanthraquinone (compound 2). Both compounds showed …
Two anthraquinones which inhibit activity of the Src tyrosine kinase were isolated from a water extract of Hedyotis diffusa WILLD. and ident …
Contamination is a frequent confounding factor in toxicology studies with anthraquinone and related compounds.
Butterworth BE, Mathre OB, Ballinger KE, Adalsteinsson O. Butterworth BE, et al. Int J Toxicol. 2004;23(5):335-44. doi: 10.1080/10915810490517072. Int J Toxicol. 2004. PMID: 15513832
Examples include 1-hydroxyanthraquinone (1-OH-AQ) and 2-hydroxyanthraquinone (2-OH-AQ), which are also metabolites of AQ. Some commercial AQ is produced by the oxidation of anthracene (AQ-OX). ...Many toxicology studies on AQ used contaminated anthracene-deri …
Examples include 1-hydroxyanthraquinone (1-OH-AQ) and 2-hydroxyanthraquinone (2-OH-AQ), which are also metabolites of A …
Presence and estrogenicity of anthracene derivatives in coastal Japanese waters.
Kurihara R, Shiraishi F, Tanaka N, Hashimoto S. Kurihara R, et al. Environ Toxicol Chem. 2005 Aug;24(8):1984-93. doi: 10.1897/04-310r.1. Environ Toxicol Chem. 2005. PMID: 16152971
The yeast two-hybrid system was also used to evaluate the estrogenic activity of these compounds. Estrogen agonist and antagonist tests with or without rat liver S9 were carried out. Some compounds showed estrogenic activity: The strongest (2-hydrox …
The yeast two-hybrid system was also used to evaluate the estrogenic activity of these compounds. Estrogen agonist and antagon …
Integrated Network Pharmacology, Molecular Modeling, LC-MS Profiling, and Semisynthetic Approach for the Roots of Rubia tinctorum L. Metabolites in Cancer Treatment.
El-Banna AA, Eltamany EE, Yassen ASA, Lotfy A, El-Tanahy AHH, Badr JM, Algandaby MM, Murshid SS, Elhady SS, Abdelhameed RFA. El-Banna AA, et al. ACS Omega. 2025 Mar 26;10(13):13027-13045. doi: 10.1021/acsomega.4c09853. eCollection 2025 Apr 8. ACS Omega. 2025. PMID: 40224436 Free PMC article.
The aim of this study is to explore the multilevel mechanisms of R. tinctorum metabolites in cancer treatment using network pharmacology, together with molecular docking and in vitro studies. The network pharmacology analysis enabled us to reveal the hit anticancer R. tinc …
The aim of this study is to explore the multilevel mechanisms of R. tinctorum metabolites in cancer treatment using network pharmacol …