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1947 2
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Quoted phrases not found in phrase index: "2-pyrol", "a-pyrrolidone"
Page 1
Pyrrolidone derivatives.
Shorvon S. Shorvon S. Lancet. 2001 Dec 1;358(9296):1885-92. doi: 10.1016/S0140-6736(01)06890-8. Lancet. 2001. PMID: 11741647 Review.
The pyrrolidone (2-oxopyrrolidine) family of chemicals has been the subject of research for more than three decades. ...
The pyrrolidone (2-oxopyrrolidine) family of chemicals has been the subject of research for more than three decades. .. …
Stoffmonographie für N-Ethyl-2-pyrrolidon (NEP) und Human-Biomonitoring (HBM)-Werte für die Metaboliten 5-Hydroxy-NEP (5-HNEP) und 2-Hydroxy-N-ethylsuccinimid (2-HESI) im Urin: Stellungnahme der Kommission Human-Biomonitoring des Umweltbundesamtes.
[No authors listed] [No authors listed] Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2015 Sep;58(9):1041-52. doi: 10.1007/s00103-015-2210-x. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2015. PMID: 26275567 German.
N-Ethyl-2-pyrrolidone (NEP), a polar aprotic solvent, is used in many applications as substitute for the structural analogue N-methyl-2-pyrrolidone (NMP), e. g. for surface coatings, in cleaning agents and paint strippers. ...Exposure to NEP can be qua …
N-Ethyl-2-pyrrolidone (NEP), a polar aprotic solvent, is used in many applications as substitute for the structural analogue N …
N-vinyl-2-pyrrolidone and polyvinyl pyrrolidone.
[No authors listed] [No authors listed] IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 3(PT 3):1181-7. IARC Monogr Eval Carcinog Risks Hum. 1999. PMID: 10476385 Free PMC article. Review. No abstract available.
Workplace environmental exposure level guide: n-Methyl-2-pyrrolidone.
[No authors listed] [No authors listed] Toxicol Ind Health. 2022 Jun;38(6):309-329. doi: 10.1177/07482337221093838. Toxicol Ind Health. 2022. PMID: 35658636
n-Methyl-2-pyrrolidone (NMP) is a widely used solvent with a mild amine-like odor that can exist in a vapor or aerosol at moderate temperatures. ...
n-Methyl-2-pyrrolidone (NMP) is a widely used solvent with a mild amine-like odor that can exist in a vapor or aerosol at mode …
Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors.
Sasaki Y, Tokuhara H, Ohba Y, Okabe A, Nakayama M, Nakagawa H, Skene R, Hoffman I, Zou H, Yoshida M. Sasaki Y, et al. Bioorg Med Chem Lett. 2020 Mar 1;30(5):126963. doi: 10.1016/j.bmcl.2020.126963. Epub 2020 Jan 13. Bioorg Med Chem Lett. 2020. PMID: 31980341
Herein we report an efficient method for the synthesis of a highly functionalized 2-pyrrolidinone, tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylate, from readily available starting materials. ...
Herein we report an efficient method for the synthesis of a highly functionalized 2-pyrrolidinone, tert-butyl 3-cyano-3-cyclop …
A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma.
Jake Shortt, Galettis P, Cheah CY, Davis J, Ludford-Menting M, Link EK, Martin JH, Koldej R, Ritchie D. Jake Shortt, et al. Clin Epigenetics. 2023 Jan 28;15(1):15. doi: 10.1186/s13148-023-01427-7. Clin Epigenetics. 2023. PMID: 36709310 Free PMC article. Clinical Trial.
BACKGROUND: N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. ...
BACKGROUND: N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous appli …
Safety Assessment of PCA (2-Pyrrolidone-5-Carboxylic Acid) and Its Salts as Used in Cosmetics.
Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B. Fiume MM, et al. Int J Toxicol. 2019 Sep/Oct;38(2_suppl):5S-11S. doi: 10.1177/1091581819856568. Int J Toxicol. 2019. PMID: 31522652 Review.
The Cosmetic Ingredient Review Expert Panel (Panel) reassessed the safety of 2-pyrrolidone-5-carboxylic acid (PCA) and sodium PCA; the Panel added 3 previously unreviewed salts (calcium, magnesium, and potassium) of PCA to this safety assessment. 2-Pyrroli …
The Cosmetic Ingredient Review Expert Panel (Panel) reassessed the safety of 2-pyrrolidone-5-carboxylic acid (PCA) and sodium …
Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors.
Li Y, Liang SH. Li Y, et al. ACS Med Chem Lett. 2025 Apr 4;16(5):719-720. doi: 10.1021/acsmedchemlett.5c00157. eCollection 2025 May 8. ACS Med Chem Lett. 2025. PMID: 40365407 Free PMC article.
This patent highlight describes a series of novel 2-pyrrolidone derivatives that act as negative allosteric modulators (NAMs) of GluN2B-containing N-methyl-d-aspartic acid receptors (NMDARs). ...
This patent highlight describes a series of novel 2-pyrrolidone derivatives that act as negative allosteric modulators (NAMs) …
N-substituted 2-pyrrolidones.
ZIENTY FB, STEAHLY GW. ZIENTY FB, et al. J Am Chem Soc. 1947 Mar;69(3):715. doi: 10.1021/ja01195a518. J Am Chem Soc. 1947. PMID: 20341877 No abstract available.
Development of a 2-pyrrolidone biosynthetic pathway in Corynebacterium glutamicum by engineering an acetyl-CoA balance route.
Xu M, Gao H, Ma Z, Han J, Zheng K, Shao M, Rao Z. Xu M, et al. Amino Acids. 2022 Nov;54(11):1437-1450. doi: 10.1007/s00726-022-03174-0. Epub 2022 Oct 13. Amino Acids. 2022. PMID: 36224443
2-Pyrrolidone is widely used in the textile and pharmaceutical industries. Here, we established a 2-pyrrolidone biosynthesis pathway in Corynebacterium glutamicum, by expressing glutamate decarboxylase (Gad) mutant and beta-alanine CoA transferase (Act …
2-Pyrrolidone is widely used in the textile and pharmaceutical industries. Here, we established a 2-pyrrolidone …
5,505 results