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83 results

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Quoted phrases not found in phrase index: "2-propanone oxime", "N-propan-2-ylidenehydroxylamine"
Page 1
Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug delivery and potentiates chemotherapy in GBM.
Jimenez-Macias JL, Vaughn-Beaucaire P, Bharati A, Xu Z, Forrest M, Hong J, Sun M, Schmidt A, Clark J, Hawkins W, Mercado N, Real J, Huntington K, Zdioruk M, Nowicki MO, Cho CF, Wu B, Li W, Logan T, Manz KE, Pennell KD, Fedeles BI, Bertone P, Punsoni M, Brodsky AS, Lawler SE. Jimenez-Macias JL, et al. Sci Adv. 2025 Feb 28;11(9):eadr1481. doi: 10.1126/sciadv.adr1481. Epub 2025 Feb 26. Sci Adv. 2025. PMID: 40009687 Free PMC article.
The indirubin-derivative, 6-bromoindirubin acetoxime (BIA), down-regulates CDH5 and other BTB signature genes, causing endothelial barrier disruption in vitro and in murine GBM xenograft models. ...
The indirubin-derivative, 6-bromoindirubin acetoxime (BIA), down-regulates CDH5 and other BTB signature genes, causing endothelial ba …
Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy.
Aourz N, Serruys AK, Chabwine JN, Balegamire PB, Afrikanova T, Edrada-Ebel R, Grey AI, Kamuhabwa AR, Walrave L, Esguerra CV, van Leuven F, de Witte PAM, Smolders I, Crawford AD. Aourz N, et al. ACS Chem Neurosci. 2019 Apr 17;10(4):1992-2003. doi: 10.1021/acschemneuro.8b00281. Epub 2018 Nov 6. ACS Chem Neurosci. 2019. PMID: 30351911 Free article.
Both indirubin and BIO-acetoxime also showed anticonvulsant activity in the pilocarpine rat model for limbic seizures and in the 6-Hz refractory seizure mouse model. Most interestingly, BIO-acetoxime also exhibited anticonvulsant actions in 6-Hz fully kindled mice. …
Both indirubin and BIO-acetoxime also showed anticonvulsant activity in the pilocarpine rat model for limbic seizures and in the 6-Hz …
GSK-3β activation is required for ZIP-induced disruption of learned fear.
Song S, Kim J, Park K, Lee J, Park S, Lee S, Kim J, Hong I, Song B, Choi S. Song S, et al. Sci Rep. 2020 Oct 26;10(1):18227. doi: 10.1038/s41598-020-75130-5. Sci Rep. 2020. PMID: 33106552 Free PMC article.
ZIP induced depotentiation (a cellular substrate of memory erasure) of conditioning-induced potentiation at LA synapses, and the ZIP-induced depotentiation was prevented by a GSK-3beta inhibitor, 6-bromoindirubin-3-acetoxime (BIO-acetoxime). Consistently, GSK-3beta …
ZIP induced depotentiation (a cellular substrate of memory erasure) of conditioning-induced potentiation at LA synapses, and the ZIP-induced …
Tailoring epoxy coating with acetoxime derivative of zinc for advanced anticorrosive performance on mild steel: experimental and computational insights.
Chopra I, Ola SK, Gopalakrishnan S, Dhayal V. Chopra I, et al. J Mol Model. 2023 Aug 30;29(9):300. doi: 10.1007/s00894-023-05705-2. J Mol Model. 2023. PMID: 37648898
CONTEXT: In this work, the corrosion inhibitive effect of acetoxime derivative of zinc chloride, (ZnCl(2).2HON=C(CH(3))(2)) (ZA), was investigated on mild steel in epoxy/polyamide coating. ...Using surface analysis and electrochemical data, it was concluded that an inhibit …
CONTEXT: In this work, the corrosion inhibitive effect of acetoxime derivative of zinc chloride, (ZnCl(2).2HON=C(CH(3))(2)) (ZA), was …
Atom economic closed-loop recycling of thermoset polyurethane foams.
Liu Z, Liu L, Li Y, Yang K, Li S, Li W, Zhu Y, Xie T. Liu Z, et al. Nat Commun. 2025 Jun 2;16(1):5117. doi: 10.1038/s41467-025-60111-x. Nat Commun. 2025. PMID: 40456726 Free PMC article.
By removing acetoxime via evaporation, the original covalent bonds are reformed and these micro-particles are rejoined to form a new foam with acetoxime as the porogen. The process employs neither catalyst nor solvent and the only chemical reagent involved (aceto …
By removing acetoxime via evaporation, the original covalent bonds are reformed and these micro-particles are rejoined to form a new …
PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models.
Zdioruk M, Jimenez-Macias JL, Nowicki MO, Manz KE, Pennell KD, Koch MS, Finkelberg T, Wu B, Boucher P, Takeda Y, Li W, Piranlioglu R, Ling AL, Chiocca EA, Lawler SE. Zdioruk M, et al. Cell Rep Med. 2023 May 16;4(5):101019. doi: 10.1016/j.xcrm.2023.101019. Epub 2023 Apr 14. Cell Rep Med. 2023. PMID: 37060903 Free PMC article.
This study investigates the impact of 6'-bromoindirubin-3'-acetoxime (BiA) on immunosuppressive mechanisms in glioblastoma (GBM) and evaluates the efficacy of a BiA nanoparticle formulation, PPRX-1701, in immunocompetent mouse GBM models. ...
This study investigates the impact of 6'-bromoindirubin-3'-acetoxime (BiA) on immunosuppressive mechanisms in glioblastoma (GBM) and …
Acetone-mediated ammonium oxidation to dinitrogen by Zobellella taiwanensis bacteria.
Lei Y, Wang Y, Tan X, Xi C, Liu H. Lei Y, et al. ISME J. 2025 Jan 2;19(1):wraf230. doi: 10.1093/ismejo/wraf230. ISME J. 2025. PMID: 41123480 Free PMC article.
Here, we discovered a new process termed acetone-mediated ammonium oxidation in Zobellella taiwanensis bacteria under both oxic and anoxic conditions, directly oxidizing ammonium to N2 (NH4+ + acetone acetoxime N2 + acetone). Acetone, produced from organic sources, cou …
Here, we discovered a new process termed acetone-mediated ammonium oxidation in Zobellella taiwanensis bacteria under both oxic and anoxic c …
Carcinogenicity test of acetoxime in MRC-Wistar rats.
Mirvish SS, Salmasi S, Runge RG. Mirvish SS, et al. J Natl Cancer Inst. 1982 Oct;69(4):961-2. J Natl Cancer Inst. 1982. PMID: 6956769
Acetoxime was tested for carcinogenicity by chronic administration in the drinking water to male and female outbred MRC-Wistar rats. ...
Acetoxime was tested for carcinogenicity by chronic administration in the drinking water to male and female outbred MRC-Wistar rats. …
Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone.
Mirvish SS, Markin RS, Lawson TA, Nickols JG. Mirvish SS, et al. Cancer Lett. 1988 Aug 15;41(2):211-6. doi: 10.1016/0304-3835(88)90118-8. Cancer Lett. 1988. PMID: 3401844
The weak liver carcinogen 3-nitroso-2-oxazolidinone (NOZ) did not induce a significant HLN frequency in MRC-Wistar rats. Acetoxime was highly volatile and was not mutagenic in the Ames test under a variety of conditions. The results for acetoxime are of interest bec …
The weak liver carcinogen 3-nitroso-2-oxazolidinone (NOZ) did not induce a significant HLN frequency in MRC-Wistar rats. Acetoxime wa …
GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling.
Duffy DJ, Krstic A, Schwarzl T, Higgins DG, Kolch W. Duffy DJ, et al. Mol Cancer Ther. 2014 Feb;13(2):454-67. doi: 10.1158/1535-7163.MCT-13-0560-T. Epub 2013 Nov 26. Mol Cancer Ther. 2014. PMID: 24282277
Inhibition of the p53 tumor suppressor partly rescued the cell death phenotype, whereas activation of canonical Wnt signaling contributed to the loss of viability, in a p53-independent manner. Two GSK3 inhibitors (BIO-acetoxime and LiCl) and one small-molecule Wnt agonist …
Inhibition of the p53 tumor suppressor partly rescued the cell death phenotype, whereas activation of canonical Wnt signaling contributed to …
83 results