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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
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1975 3
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1981 1
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1985 3
1986 4
1987 1
1988 1
1990 1
1991 1
1992 3
1993 5
1994 7
1995 6
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1997 3
1999 3
2000 9
2001 10
2002 10
2003 21
2004 13
2005 16
2006 22
2007 14
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2009 14
2010 21
2011 13
2012 20
2013 33
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532 results

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Page 1
Propargylamine: an important moiety in drug discovery.
Carneiro A, Uriarte E, Borges F, Matos MJ. Carneiro A, et al. Future Med Chem. 2023 Jan;15(2):211-224. doi: 10.4155/fmc-2022-0243. Epub 2023 Feb 21. Future Med Chem. 2023. PMID: 36802855 Review.
Propargylamine is a chemical moiety whose properties have made it a widely distributed group within the fields of medicinal chemistry and chemical biology. ...The principal therapeutic fields where propargylamine-based compounds have made an impact are identified, a …
Propargylamine is a chemical moiety whose properties have made it a widely distributed group within the fields of medicinal chemistry …
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.
do Carmo Carreiras M, Ismaili L, Marco-Contelles J. do Carmo Carreiras M, et al. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126880. doi: 10.1016/j.bmcl.2019.126880. Epub 2019 Dec 9. Bioorg Med Chem Lett. 2020. PMID: 31864798 Review.
Current options for the treatment of Alzheimers disease have been restricted to prescription of acetylcholinesterase inhibitors or N-methyl-d-aspartate receptor antagonist, memantine. Propargylamine-derived multi-target directed ligands, such as ladostigil, M30, ASS234 and …
Current options for the treatment of Alzheimers disease have been restricted to prescription of acetylcholinesterase inhibitors or N-methyl- …
The pharmacology of selegiline.
Magyar K. Magyar K. Int Rev Neurobiol. 2011;100:65-84. doi: 10.1016/B978-0-12-386467-3.00004-2. Int Rev Neurobiol. 2011. PMID: 21971003 Review.
Selegiline, the R-optical enantiomer of deprenyl (phenyl-isopropyl-methyl-propargylamine), was almost exclusively used MAO-B inhibitor during the past decades to treat Parkinson's disease. ...
Selegiline, the R-optical enantiomer of deprenyl (phenyl-isopropyl-methyl-propargylamine), was almost exclusively used MAO-B inhibito …
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.
Meiring L, Petzer JP, Legoabe LJ, Petzer A. Meiring L, et al. Bioorg Med Chem Lett. 2022 Jul 1;67:128746. doi: 10.1016/j.bmcl.2022.128746. Epub 2022 Apr 18. Bioorg Med Chem Lett. 2022. PMID: 35447344
Monoamine oxidase B (MAO-B) inhibitors are established therapy for Parkinson's disease and act, in part, by blocking the MAO-catalysed metabolism of dopamine in the brain. Two propargylamine-containing MAO-B inhibitors, selegiline [(R)-deprenyl] and rasagiline, are current …
Monoamine oxidase B (MAO-B) inhibitors are established therapy for Parkinson's disease and act, in part, by blocking the MAO-catalysed metab …
Covalent Irreversible Inhibitors of Tetracycline Destructases.
Li R, Xue YP, Le ST, Tang WK, Tolia NH, Dantas G, Wencewicz TA. Li R, et al. ACS Infect Dis. 2025 Sep 12;11(9):2476-2490. doi: 10.1021/acsinfecdis.5c00322. Epub 2025 Aug 30. ACS Infect Dis. 2025. PMID: 40884835 Free PMC article.
The reactive warheads were installed via a one-step Mannich reaction linking either an N-(1-methyl)cyclopropylamine or N-propargylamine group to the C9-position of the aTC D-ring via an amino methylene linkage. We also synthesized two nonspecific FMO inhibitors, N-(1-methy …
The reactive warheads were installed via a one-step Mannich reaction linking either an N-(1-methyl)cyclopropylamine or N-propargylamine …
Click-Ready Gold Nanoparticles from Aqueous Mechanochemistry: 2-Propynylamine as a Reducing Agent and Surface Ligand.
Garcia AL, Mitchell BS, Reusch A, Fink MJ, Hinestroza JP, Ko Y, Vanegas JP. Garcia AL, et al. Materials (Basel). 2025 Sep 25;18(19):4470. doi: 10.3390/ma18194470. Materials (Basel). 2025. PMID: 41095295 Free PMC article.
We report a rapid aqueous method for synthesizing monodisperse gold nanoparticles (AuNPs), employing 2-propynylamine as both an intrinsic reducing agent and a surface-stabilizing ligand. ...Control experiments using alternate milling times and vial composition confi …
We report a rapid aqueous method for synthesizing monodisperse gold nanoparticles (AuNPs), employing 2-propynylamine as both a …
Synthesis of α,δ-Disubstituted Tetraphosphates and Terminally-Functionalized Nucleoside Pentaphosphates.
Shepard SM, Kim H, Bang QX, Alhokbany N, Cummins CC. Shepard SM, et al. J Am Chem Soc. 2021 Jan 13;143(1):463-470. doi: 10.1021/jacs.0c11884. Epub 2020 Dec 29. J Am Chem Soc. 2021. PMID: 33375782 Free PMC article.
Treatment under anhydrous conditions with an alkylamine base and a nucleophile (HNuc(1)), such as an alcohol (neopentanol, cyclohexanol, 4-methylumbelliferone, and Boc-Tyr-OMe), an amine (propargylamine, diethylamine, morpholine, 3,5-dimethylaniline, and isopropylamine), d …
Treatment under anhydrous conditions with an alkylamine base and a nucleophile (HNuc(1)), such as an alcohol (neopentanol, cyclohexanol, 4-m …
Flexible Semi-synthesis of UFM1(1-82)-Propargylamine by Aminolysis with Valine-Propargylamine.
Hua X, Han X, Ji R, Li P, Wang Y, Guo Y, Shi J. Hua X, et al. Org Lett. 2025 Feb 14;27(6):1362-1366. doi: 10.1021/acs.orglett.4c04546. Epub 2025 Feb 3. Org Lett. 2025. PMID: 39899039
We report a novel semi-synthetic strategy of UFM1(1-82)-propargylamine by N-S acyl transfer to give UFM1(1-80)R thioester and subsequent aminolysis with valine-propargylamine. The use of the valine-propargylamine molecule overcomes the inability of the valine …
We report a novel semi-synthetic strategy of UFM1(1-82)-propargylamine by N-S acyl transfer to give UFM1(1-80)R thioester and subsequ …
Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.
Dyck LE, Davis BA. Dyck LE, et al. Drug Metab Dispos. 2001 Aug;29(8):1156-61. Drug Metab Dispos. 2001. PMID: 11454735
(R)-N-(2-Heptyl)-N-methyl-propargylamine (R-2HMP) and (R)-N-(2-heptyl)-propargylamine (R-2HPA) are analogs of R-deprenyl. ...
(R)-N-(2-Heptyl)-N-methyl-propargylamine (R-2HMP) and (R)-N-(2-heptyl)-propargylamine (R-2HPA) are analogs of R-deprenyl. ...
532 results