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Page 1
2,2',4,4',5,5'- and 3,3',4,4',5,5'-hexachlorobiphenyl alteration of uterine progesterone and estrogen receptors coincides with embryotoxicity in mink (Mustela vision).
Patnode KA, Curtis LR. Patnode KA, et al. Toxicol Appl Pharmacol. 1994 Jul;127(1):9-18. doi: 10.1006/taap.1994.1133. Toxicol Appl Pharmacol. 1994. PMID: 8048058
Anestrous, juvenile female mink and pregnant adult mink were exposed to 3,3',4,4',5,5'-hexachlorobiphenyl (3HCB), a coplanar polychlorinated biphenyl (PCB), or 2,2',4,4',5,5'-hexachlorobiphenyl (2HCB), a noncoplanar PCB congener. ...
Anestrous, juvenile female mink and pregnant adult mink were exposed to 3,3',4,4',5,5'-hexachlorobiphenyl …
Effects of maternal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) on testicular steroidogenesis and spermatogenesis in male offspring rats.
Yamamoto M, Narita A, Kagohata M, Shirai M, Akahori F, Arishima K. Yamamoto M, et al. J Androl. 2005 Mar-Apr;26(2):205-14. doi: 10.1002/j.1939-4640.2005.tb01087.x. J Androl. 2005. PMID: 15713826 Free article.
On days 7-21 of gestation, Sprague-Dawley rats were orally administered 3 or 30 mug/kg/d of 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) daily. Their male offspring were autopsied at 3, 6, and 15 weeks a …
On days 7-21 of gestation, Sprague-Dawley rats were orally administered 3 or 30 mug/kg/d of 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3 …
Adverse effects of neonatal exposure to 3,3',4,4',5,5'-hexachlorobiphenyl on hormone levels and testicular function in male Sprague-Dawley rats.
Xiao W, Zhang J, Liang J, Zhu H, Zhou Z, Wu Q. Xiao W, et al. Environ Toxicol. 2011 Nov;26(6):657-68. doi: 10.1002/tox.20677. Epub 2011 Mar 3. Environ Toxicol. 2011. PMID: 21374784
In this study, we investigated the time-course changes of hormone levels and sperm numbers in male Sprague-Dawley (SD) rats after neonatal exposure to 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169). Neonatal rats were given (through oral gavages) do …
In this study, we investigated the time-course changes of hormone levels and sperm numbers in male Sprague-Dawley (SD) rats after neonatal e …
PCBs: structure-function relationships and mechanism of action.
Safe S, Bandiera S, Sawyer T, Robertson L, Safe L, Parkinson A, Thomas PE, Ryan DE, Reik LM, Levin W, et al. Safe S, et al. Environ Health Perspect. 1985 May;60:47-56. doi: 10.1289/ehp.856047. Environ Health Perspect. 1985. PMID: 2992927 Free PMC article. Review.
The most active PCB congeners, 3,4,4',5-tetra-, 3,3',4,4'-tetra-, 3,3',4,4',5-penta- and 3,3',4,4',5,5'-hexachlorobiphenyl, are substituted at both para and at two or more meta positions. ...
The most active PCB congeners, 3,4,4',5-tetra-, 3,3',4,4'-tetra-, 3,3',4,4',5-penta- and 3,3',4,4',5,5'-hexac …
Halogenated biphenyls: molecular toxicology.
Safe S, Robertson LW, Safe L, Parkinson A, Bandiera S, Sawyer T, Campbell MA. Safe S, et al. Can J Physiol Pharmacol. 1982 Jul;60(7):1057-64. doi: 10.1139/y82-151. Can J Physiol Pharmacol. 1982. PMID: 6812934
The most toxic PCBs, namely 3,3',4,4'-tetra-, 3,3',4,4',5-penta- and 3,3',4,4',5,5'-hexachlorobiphenyl are substituted in at least one meta and para position on both phenyl rings (i.e., the lateral positions) and contain no ortho-chloro substitu …
The most toxic PCBs, namely 3,3',4,4'-tetra-, 3,3',4,4',5-penta- and 3,3',4,4',5,5'-hexachlorobiphenyl ar …
Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity.
Safe S. Safe S. Mutat Res. 1989 Jan;220(1):31-47. doi: 10.1016/0165-1110(89)90007-9. Mutat Res. 1989. PMID: 2492077 Review.
Based on the structure-activity relationships for PCBs (Safe, 1984) it is unlikely that the more toxic compounds such as 3,3',4,4',5-penta- and 3,3',4,4',5,5'-hexachlorobiphenyl, would form covalent adducts with DNA. (2) PCB mixtures and individ …
Based on the structure-activity relationships for PCBs (Safe, 1984) it is unlikely that the more toxic compounds such as 3,3',4,4',5-penta- …
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.
Safe S, Bandiera S, Sawyer T, Zmudzka B, Mason G, Romkes M, Denomme MA, Sparling J, Okey AB, Fujita T. Safe S, et al. Environ Health Perspect. 1985 Sep;61:21-33. doi: 10.1289/ehp.856121. Environ Health Perspect. 1985. PMID: 2998747 Free PMC article. Review.
Previous in vivo studies have shown that the most active PCB congeners 3,3',4,4'-tetra-, 3,4,4',5-tetra-, 3,3',4,4',5-penta-, and 3,3',4,4',5,5'-hexachlorobiphenyl, cause many of the biologic and toxic effects reported for the highly toxic halog …
Previous in vivo studies have shown that the most active PCB congeners 3,3',4,4'-tetra-, 3,4,4',5-tetra-, 3,3',4,4',5-penta-, and 3, …
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.
Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE. Van den Berg M, et al. Toxicol Sci. 2006 Oct;93(2):223-41. doi: 10.1093/toxsci/kfl055. Epub 2006 Jul 7. Toxicol Sci. 2006. PMID: 16829543 Free PMC article. Review.
Changes were decided by the expert panel for 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (TEF = 0.3), 1,2,3,7,8-pentachlorodibenzofuran (PeCDF) (TEF = 0.03), octachlorodibenzo-p-dioxin and octachlorodibenzofuran (TEFs = 0.0003), 3,4,4',5-tetrachlorbiphenyl (PCB 81) (TEF = 0.0003), …
Changes were decided by the expert panel for 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (TEF = 0.3), 1,2,3,7,8-pentachlorodibenzofuran (PeCDF …
67 results