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Page 1
Protection against Metabolic Associated Fatty Liver Disease by Protocatechuic Acid.
Tan J, Hu R, Gong J, Fang C, Li Y, Liu M, He Z, Hou DX, Zhang H, He J, Wu S. Tan J, et al. Gut Microbes. 2023 Jan-Dec;15(1):2238959. doi: 10.1080/19490976.2023.2238959. Gut Microbes. 2023. PMID: 37505920 Free PMC article.
We first investigated the effects of cyanidin 3-glucoside and its phenolic metabolites on high-fat diet induced MAFLD in C57BL/6J mice, and protocatechuic acid (PCA) showed a significant positive effect. Next, regulation of PCA on lipid metabolism and gut microbiota …
We first investigated the effects of cyanidin 3-glucoside and its phenolic metabolites on high-fat diet induced MAFLD in C57BL/6J mice, and …
Protocatechuic acid modulates the circadian rhythm of keratinocytes and maintains skin barrier integrity.
Lee J, Kim JY, Lee JH, Lee KH. Lee J, et al. Mol Biol Rep. 2025 Jul 28;52(1):765. doi: 10.1007/s11033-025-10880-x. Mol Biol Rep. 2025. PMID: 40721875
Disruption of these rhythms accelerates skin aging, compromises barrier integrity, and increases susceptibility to oxidative stress. Protocatechuic acid (PCA) is a naturally occurring compound with antioxidant and anti-inflammatory properties; however, its role in r …
Disruption of these rhythms accelerates skin aging, compromises barrier integrity, and increases susceptibility to oxidative stress. Prot …
Protocatechuic Acid Delays Postovulatory Oocyte Ageing in Mouse.
Li LJ, Chao S, Zhao SX, Lu J, Zhang XY, Zhao Y, Zhao MH, Huang GA, Yin S, Sun QY, Zhao L, Ge ZJ. Li LJ, et al. Mol Nutr Food Res. 2023 Feb;67(4):e2200363. doi: 10.1002/mnfr.202200363. Epub 2023 Jan 26. Mol Nutr Food Res. 2023. PMID: 36537853
SCOPE: Tea is a popular beverage worldwide and has many health functions. Protocatechuic acid (PCA) is an important bioactive component of tea and has benefit to health. ...
SCOPE: Tea is a popular beverage worldwide and has many health functions. Protocatechuic acid (PCA) is an important bioactive …
Protocatechuic acid as an inhibitor of lipid oxidation in meat.
Deuchande T, Fundo JF, Pintado ME, Amaro AL. Deuchande T, et al. Meat Sci. 2024 Jul;213:109519. doi: 10.1016/j.meatsci.2024.109519. Epub 2024 Apr 19. Meat Sci. 2024. PMID: 38663116 Free article.
Currently, synthetic antioxidants are used to prevent oxidation, but increasing consumer demand for natural ones leaves the industry with few alternatives. In this study, protocatechuic acid (PCA), known to have high antioxidant activity, was evaluated as a potentia …
Currently, synthetic antioxidants are used to prevent oxidation, but increasing consumer demand for natural ones leaves the industry with fe …
The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review.
Cadena-Iñiguez J, Santiago-Osorio E, Sánchez-Flores N, Salazar-Aguilar S, Soto-Hernández RM, Riviello-Flores ML, Macías-Zaragoza VM, Aguiñiga-Sánchez I. Cadena-Iñiguez J, et al. Molecules. 2024 Mar 23;29(7):1439. doi: 10.3390/molecules29071439. Molecules. 2024. PMID: 38611719 Free PMC article. Review.
A remarkable example of this group is protocatechuic acid (PCA), which has been the subject of various revealing research on its activities in different areas. These studies sustain that protocatechuic acid has anti-inflammatory, antimutagenic, antidia …
A remarkable example of this group is protocatechuic acid (PCA), which has been the subject of various revealing research on i …
3,4-Dihydroxybenzoic acid methyl ester from Vespa velutina auraria Smith against rheumatoid arthritis via modulating the apoptosis and inflammation through NF-kappaB pathway.
Che YH, Liu CH, Pang XQ, Liu H, Yang ZB, Wang JP, Xiao H. Che YH, et al. Inflammopharmacology. 2025 May;33(5):2699-2710. doi: 10.1007/s10787-025-01747-5. Epub 2025 May 31. Inflammopharmacology. 2025. PMID: 40448819
From compounds extracted from Vespa velutina auraria Smith, 3,4-dihydroxybenzoic acid methyl ester (DBME) showed the most effective anti-inflammatory response in RAW264.7 cells according to our prior investigation. ...
From compounds extracted from Vespa velutina auraria Smith, 3,4-dihydroxybenzoic acid methyl ester (DBME) showed …
Protocatechuic Acid Suppresses Lipid Uptake and Synthesis through the PPARgamma Pathway in High-Fat Diet-Induced NAFLD Mice.
Li J, Li C, Wu X, Dong Y, Li Y, Jiao X, Li J, Han L, Wang M. Li J, et al. J Agric Food Chem. 2025 Feb 19;73(7):4012-4026. doi: 10.1021/acs.jafc.4c01354. Epub 2025 Feb 5. J Agric Food Chem. 2025. PMID: 39907525
As one of the main metabolites of anthocyanins, protocatechuic acid (PCA) exhibited strong activity to improve NAFLD, but the specific mechanism remains unclear. ...
As one of the main metabolites of anthocyanins, protocatechuic acid (PCA) exhibited strong activity to improve NAFLD, but the …
Neuroinflammatory suppression with protocatechuic acid attenuates Alzheimer's disease phenotypes in 5 FAD transgenic mice.
Kim Y, Cho M, Jeon CJ, Goh G, Kim M. Kim Y, et al. Biomed Pharmacother. 2025 Nov;192:118598. doi: 10.1016/j.biopha.2025.118598. Epub 2025 Sep 23. Biomed Pharmacother. 2025. PMID: 40991989 Free article.
Increasing evidence suggests that the aberrant activation of glial cells, including microglia and astrocytes, is a significant early characteristic that accelerates neuroinflammatory processes in the development of AD. Protocatechuic acid (PCA), a natural phenolic c …
Increasing evidence suggests that the aberrant activation of glial cells, including microglia and astrocytes, is a significant early charact …
Protocatechuic acid protects hepatocytes against hydrogen peroxide-induced oxidative stress.
Lee WJ, Lee SH. Lee WJ, et al. Curr Res Food Sci. 2022 Jan 13;5:222-227. doi: 10.1016/j.crfs.2022.01.006. eCollection 2022. Curr Res Food Sci. 2022. PMID: 35106486 Free PMC article.
Among the major target organs attacked by reactive oxygen species (ROS) is the liver. Protocatechuic acid (PCA) is a phenolic compound found in green tea, acai oil and some mushroom species that possesses strong antioxidative and anti-inflammatory activity and may h …
Among the major target organs attacked by reactive oxygen species (ROS) is the liver. Protocatechuic acid (PCA) is a phenolic …
Iron dissolution from fayalitic slag with 3,4-dihydroxybenzoic acid under different redox and alkaline conditions.
Bagheri S, Mankinen O, Telkki VV, Luukkonen T, Yliniemi J. Bagheri S, et al. Chemosphere. 2025 May;377:144350. doi: 10.1016/j.chemosphere.2025.144350. Epub 2025 Mar 25. Chemosphere. 2025. PMID: 40138739 Free article.
In particular, their behavior under diverse chemical conditions is complex and not well understood. This study investigates the impact of 3,4-dihydroxybenzoic acid (DHBA) with 1 mM concentration on the redox chemistry and dissolution of FS within the a …
In particular, their behavior under diverse chemical conditions is complex and not well understood. This study investigates the impact of …
3,484 results