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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1873 1
1910 1
1917 1
1926 1
1936 1
1938 1
1945 2
1946 5
1947 4
1948 1
1949 5
1950 5
1951 2
1952 5
1953 9
1954 8
1955 4
1956 12
1957 8
1958 6
1959 14
1960 7
1961 8
1962 11
1963 15
1964 22
1965 17
1966 20
1967 8
1968 8
1969 17
1970 17
1971 20
1972 23
1973 19
1974 21
1975 36
1976 26
1977 44
1978 31
1979 43
1980 48
1981 70
1982 40
1983 54
1984 75
1985 80
1986 73
1987 87
1988 102
1989 92
1990 66
1991 10
1992 36
1993 34
1994 33
1995 30
1996 32
1997 32
1998 28
1999 46
2000 38
2001 50
2002 29
2003 26
2004 34
2005 35
2006 44
2007 44
2008 34
2009 33
2010 23
2011 38
2012 37
2013 43
2014 46
2015 68
2016 59
2017 52
2018 71
2019 83
2020 83
2021 73
2022 79
2023 92
2024 26

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2,629 results

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Page 1
The cardiovascular benefits of dark chocolate.
Kerimi A, Williamson G. Kerimi A, et al. Vascul Pharmacol. 2015 Aug;71:11-5. doi: 10.1016/j.vph.2015.05.011. Epub 2015 May 27. Vascul Pharmacol. 2015. PMID: 26026398 Free article. Review.
Dark chocolate contains many biologically active components, such as catechins, procyanidins and theobromine from cocoa, together with added sucrose and lipids. All of these can directly or indirectly affect the cardiovascular system by multiple mechanisms. ...For chocolat …
Dark chocolate contains many biologically active components, such as catechins, procyanidins and theobromine from cocoa, together wit …
Pentoxifylline.
[No authors listed] [No authors listed] 2020 Jul 20. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2020 Jul 20. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000441 Free Books & Documents. Review.
3-Methylxanthine production through biodegradation of theobromine by Aspergillus sydowii PT-2.
Zhou B, Ma C, Zheng C, Xia T, Ma B, Liu X. Zhou B, et al. BMC Microbiol. 2020 Aug 27;20(1):269. doi: 10.1186/s12866-020-01951-z. BMC Microbiol. 2020. PMID: 32854634 Free PMC article.
We speculated that these candidate isolates also could degrade and convert theobromine through N-demethylation and oxidation. In this study, seven tea-derived fungal strains were inoculated into various theobromine agar medias and theobromine liquid mediums t …
We speculated that these candidate isolates also could degrade and convert theobromine through N-demethylation and oxidation. In this …
Exploring cocoa properties: is theobromine a cognitive modulator?
Cova I, Leta V, Mariani C, Pantoni L, Pomati S. Cova I, et al. Psychopharmacology (Berl). 2019 Feb;236(2):561-572. doi: 10.1007/s00213-019-5172-0. Epub 2019 Jan 31. Psychopharmacology (Berl). 2019. PMID: 30706099 Review.
Other active components of cocoa are methylxanthines (caffeine and theobromine). Whereas the effects of caffeine are extensively researched, the same is not the case for theobromine; this review summarizes evidence on the effect of theobromine on cognitive fu …
Other active components of cocoa are methylxanthines (caffeine and theobromine). Whereas the effects of caffeine are extensively rese …
Theobromine.
[No authors listed] [No authors listed] IARC Monogr Eval Carcinog Risks Hum. 1991;51:421-41. IARC Monogr Eval Carcinog Risks Hum. 1991. PMID: 2033793 Free PMC article. Review. No abstract available.
7-Methylxanthine Inhibits the Formation of Monosodium Urate Crystals by Increasing Its Solubility.
Costa-Bauza A, Grases F. Costa-Bauza A, et al. Biomolecules. 2023 Dec 10;13(12):1769. doi: 10.3390/biom13121769. Biomolecules. 2023. PMID: 38136640 Free PMC article.
Our results suggest that prevention of crystallization in vivo could be achieved by direct oral administration of 7-methylxanthine or other methylxanthines that are metabolized to 7-methylxanthine. For example, the hepatic metabolism of theobromine leads to significant pla …
Our results suggest that prevention of crystallization in vivo could be achieved by direct oral administration of 7-methylxanthine or other …
Theobromine and the pharmacology of cocoa.
Smit HJ. Smit HJ. Handb Exp Pharmacol. 2011;(200):201-34. doi: 10.1007/978-3-642-13443-2_7. Handb Exp Pharmacol. 2011. PMID: 20859797 Review.
The effects of theobromine in man are underresearched, possibly owing to the assumption that it is behaviourally inert. ...Of all constituents proposed to play a role in our liking for chocolate, caffeine is the most convincing, though a role for theobromine cannot …
The effects of theobromine in man are underresearched, possibly owing to the assumption that it is behaviourally inert. ...Of all con …
Caffeine and Theobromine.
Pearson LJ, Marth EH. Pearson LJ, et al. J Food Prot. 1990 Jan;53(1):47-50. doi: 10.4315/0362-028X-53.1.47. J Food Prot. 1990. PMID: 31003314 Free article.
Two components of cocoa powder, caffeine (1,3,7-trimethylxanthine) and theobromine (3,7-dimethylxanthine), were evaluated for their effect on growth of L. monocytogenes strain V7. ...Both compounds allowed some growth of the pathogen; however, longer l …
Two components of cocoa powder, caffeine (1,3,7-trimethylxanthine) and theobromine (3,7-dimethylxanthine), were …
Association between dietary theobromine with depression: a population-based study.
Li XY, Liu H, Zhang LY, Yang XT. Li XY, et al. BMC Psychiatry. 2022 Dec 6;22(1):769. doi: 10.1186/s12888-022-04415-y. BMC Psychiatry. 2022. PMID: 36474233 Free PMC article.
Participants' daily theobromine intake was determined using a 24-h food questionnaire from the 2017-2018 cycle. ...The results of multivariate logistic regression showed a correlation between depressive symptoms and theobromine intake (OR:1.17, 95%CI:1.02-1.34). CON …
Participants' daily theobromine intake was determined using a 24-h food questionnaire from the 2017-2018 cycle. ...The results of mul …
Investigation of anticancer properties of caffeinated complexes via computational chemistry methods.
Sayin K, Üngördü A. Sayin K, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Mar 15;193:147-155. doi: 10.1016/j.saa.2017.12.013. Epub 2017 Dec 6. Spectrochim Acta A Mol Biomol Spectrosc. 2018. PMID: 29223460
Computational investigations were performed for 1,3,7-trimethylpurine-2,6-dione, 3,7-dimethylpurine-2,6-dione, their Ru(II) and Os(III) complexes. ...
Computational investigations were performed for 1,3,7-trimethylpurine-2,6-dione, 3,7-dimethylpurine-2,6- …
2,629 results