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1981 2
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1990 21
1991 10
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Quoted phrases not found in phrase index: "3,9-dihydro-3-propyl-1H-purine-2,6-dione", "3-propyl-7H-purine-2,6-dione"
Page 1
A therapeutic strategy to prevent morphine dependence and tolerance by coadministration of cAMP-related reagents with morphine.
Itoh A, Noda Y, Mamiya T, Hasegawa T, Nabeshima T. Itoh A, et al. Methods Find Exp Clin Pharmacol. 1998 Sep;20(7):619-25. doi: 10.1358/mf.1998.20.7.485728. Methods Find Exp Clin Pharmacol. 1998. PMID: 9819808 Free article. Review.
To evaluate the contribution of cAMP, we investigated the effects of nefiracetam [N-(2,6-dimethyl-phenyl)-2(2-oxo-1-pyrrolidinyl)acetamide] and phosphodiesterase inhibitors (theophylline, enprofylline and rolipram) on the development of morphine dependence/tolerance. ...Ho …
To evaluate the contribution of cAMP, we investigated the effects of nefiracetam [N-(2,6-dimethyl-phenyl)-2(2-oxo-1-pyrrolidinyl)acetamide] …
Effects of enprofylline and theophylline may show the role of adenosine.
Persson CG, Andersson KE, Kjellin G. Persson CG, et al. Life Sci. 1986 Mar 24;38(12):1057-72. doi: 10.1016/0024-3205(86)90241-9. Life Sci. 1986. PMID: 3007902 Review.
Investigations into the actions of xanthines and their structure activity relationships have identified xanthine compounds like enprofylline (3-propylxanthine) that only has some actions in common with theophylline and that has a negligible ability to antagonize adenosine. …
Investigations into the actions of xanthines and their structure activity relationships have identified xanthine compounds like enprofyll
Protein binding of enprofylline.
Tegnér K, Borgå O, Svensson I. Tegnér K, et al. Eur J Clin Pharmacol. 1983;25(5):703-8. doi: 10.1007/BF00542362. Eur J Clin Pharmacol. 1983. PMID: 6420163
The protein binding of enprofylline, 3-propylxanthine, in plasma was studied by equilibrium dialysis and ultrafiltration under various experimental conditions. A limited comparison with theophylline was also undertaken. The mean fraction of enprofylline bound in hum …
The protein binding of enprofylline, 3-propylxanthine, in plasma was studied by equilibrium dialysis and ultrafiltration under variou …
Long-term xanthine therapy of asthma. Enprofylline and theophylline compared. International Enprofylline Study Group.
Chapman KR, Ljungholm K, Kallen A. Chapman KR, et al. Chest. 1994 Nov;106(5):1407-13. doi: 10.1378/chest.106.5.1407. Chest. 1994. PMID: 7956392 Clinical Trial.
We compared the long-term efficacy and tolerability of enprofylline and theophylline given over a 1-year period to adults with asthma. ...In some subjects receiving enprofylline, serum enprofylline levels rose progressively despite constant oral dosage of the …
We compared the long-term efficacy and tolerability of enprofylline and theophylline given over a 1-year period to adults with asthma …
Pharmacokinetics of enprofylline administered intravenously and as a sustained-release tablet at steady state in children with asthma.
Watson WT, Simons KJ, Simons FE. Watson WT, et al. J Pediatr. 1988 Apr;112(4):658-62. doi: 10.1016/s0022-3476(88)80193-8. J Pediatr. 1988. PMID: 3351694
The pharmacokinetics of enprofylline (3-propylxanthine) were studied in 10 children with asthma (mean age 7.9 years), after enprofylline 1 mg/kg given intravenously and after enprofylline 7.5 +/- 1.3 mg/kg given as a sustained-release tablet after 8 days of o …
The pharmacokinetics of enprofylline (3-propylxanthine) were studied in 10 children with asthma (mean age 7.9 years), after enprof
The effect of theophylline and enprofylline on allergen-induced bronchoconstriction.
Pauwels R, Van Renterghem D, Van der Straeten M, Johannesson N, Persson CG. Pauwels R, et al. J Allergy Clin Immunol. 1985 Oct;76(4):583-90. doi: 10.1016/0091-6749(85)90779-1. J Allergy Clin Immunol. 1985. PMID: 4056246 Clinical Trial.
Both theophylline and enprofylline caused a minor initial bronchodilatation. Theophylline and enprofylline slightly but significantly attenuated the immediate bronchoconstricting reaction after allergen inhalation. Theophylline and enprofylline had a signific …
Both theophylline and enprofylline caused a minor initial bronchodilatation. Theophylline and enprofylline slightly but signif …
Development of safer xanthine drugs for treatment of obstructive airways disease.
Persson CG. Persson CG. J Allergy Clin Immunol. 1986 Oct;78(4 Pt 2):817-24. doi: 10.1016/0091-6749(86)90067-9. J Allergy Clin Immunol. 1986. PMID: 3534062 Review.
After a brief review of the chemical history of antiasthma xanthines (the first limited attempts to develop novel derivatives 30 to 40 years ago), and some recent structure-activity findings, this article discusses the pharmacology of a selected xanthine derivative, enprofylli
After a brief review of the chemical history of antiasthma xanthines (the first limited attempts to develop novel derivatives 30 to 40 years …
Time-dependent changes in the pharmacokinetics and renal excretion of xanthine derivative enprofylline induced by bacterial endotoxin in rats.
Nadai M, Hasegawa T, Wang L, Haghgoo S, Nabeshima T, Kato N. Nadai M, et al. Biol Pharm Bull. 1995 Aug;18(8):1089-93. doi: 10.1248/bpb.18.1089. Biol Pharm Bull. 1995. PMID: 8535402
LPS-induced decreases in the CLr for enprofylline and GFR continued over the testing period of 120 min. The time-dependent effect of LPS on the pharmacokinetics of enprofylline was examined by a single injection of enprofylline (2.5 mg/kg) to rats pretreated …
LPS-induced decreases in the CLr for enprofylline and GFR continued over the testing period of 120 min. The time-dependent effect of …
Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.
Nadai M, Kato M, Yoshizumi H, Kimura M, Kurono S, Abe F, Saito H, Hasegawa T. Nadai M, et al. Life Sci. 2007 Sep 22;81(15):1175-82. doi: 10.1016/j.lfs.2007.07.032. Epub 2007 Aug 30. Life Sci. 2007. PMID: 17897683
Whether organic anion and cation transporters are involved in the renal excretion of xanthine derivatives, 3-methylxanthie and enprofylline, remains unclear. In this study, we have investigated the effects of typically predominant substrates for organic anion and cation tr …
Whether organic anion and cation transporters are involved in the renal excretion of xanthine derivatives, 3-methylxanthie and enprofylli
Efficacy and safety profile of xanthines in COPD: a network meta-analysis.
Cazzola M, Calzetta L, Barnes PJ, Criner GJ, Martinez FJ, Papi A, Gabriella Matera M. Cazzola M, et al. Eur Respir Rev. 2018 May 2;27(148):180010. doi: 10.1183/16000617.0010-2018. Print 2018 Jun 30. Eur Respir Rev. 2018. PMID: 29720510 Free PMC article. Review.
257 results