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Quoted phrase not found in phrase index: "3-(4-phenylpiperazin-1-yl)propane-1,2-diol"
Page 1
Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review.
Machado AKMDS, Nemitz MC, Todeschini V, Sangoi MDS. Machado AKMDS, et al. Crit Rev Anal Chem. 2021;51(2):174-182. doi: 10.1080/10408347.2019.1700098. Epub 2019 Dec 9. Crit Rev Anal Chem. 2021. PMID: 31814444 Review.
Dropropizine is a peripheral antitussive drug that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors. ...In addition, the methodologies addressed the determination of dropropizine or levodropropizine in diff …
Dropropizine is a peripheral antitussive drug that acts by inhibiting cough reflex through its action on the peripheral receptors and …
Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough.
Banderali G, Riva E, Fiocchi A, Cordaro CI, Giovannini M. Banderali G, et al. J Int Med Res. 1995 May-Jun;23(3):175-83. doi: 10.1177/030006059502300304. J Int Med Res. 1995. PMID: 7649341 Clinical Trial.
Patients randomly received either 1 mg/kg dropropizine or 2 mg/kg levodropropizine orally, three times daily for 3 days. There were statistically significant decreases in the frequency of coughing spells and nocturnal awakenings after both levodropropizine and dropropiz …
Patients randomly received either 1 mg/kg dropropizine or 2 mg/kg levodropropizine orally, three times daily for 3 days. There were s …
Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
Abdallah OM. Abdallah OM. Int J Anal Chem. 2010;2010:704564. doi: 10.1155/2010/704564. Epub 2010 Jun 29. Int J Anal Chem. 2010. PMID: 20671996 Free PMC article.
Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT). ...Beer's law was obeyed in the range of 5-45 mug mL(-1) for guaifenesin and 10-8 …
Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense wi …
Enantioselective LC-ESI-MS/MS determination of dropropizine enantiomers in rat plasma and application to a pharmacokinetic study.
Balaji N, Gabani BB, Todmal U, Sulochana SP, Saini NK, Chandran R, Mullangi R. Balaji N, et al. Biomed Chromatogr. 2019 Mar;33(3):e4434. doi: 10.1002/bmc.4434. Epub 2018 Dec 11. Biomed Chromatogr. 2019. PMID: 30426526
Dropropizine enantiomers and carbamazepine (internal standard) were extracted from 50 muL rat plasma using ethyl acetate. ...The method was successfully used in a stereoselective pharmacokinetic study of dropropizine enantiomers in rats following oral administration …
Dropropizine enantiomers and carbamazepine (internal standard) were extracted from 50 muL rat plasma using ethyl acetate. ...The meth …
Stereoselective pharmacokinetics and tissue distribution of levodropropizine after administration of pure levodropropizine and the rac-dropropizine to Sprague-Dawley rats.
Gabani BB, Todmal U, Saini NK, Balakrishna VA, Sulochana SP, Timmapuram A, Zainuddin M, Balaji N, Shuvranshu P, Srinivas NR, Mullangi R. Gabani BB, et al. Xenobiotica. 2020 Feb;50(2):135-144. doi: 10.1080/00498254.2019.1599148. Epub 2019 May 10. Xenobiotica. 2020. PMID: 30896275
Validated methods were used to quantitate LDP, DDP and rac-dropropizine.No stereoselectivity in pharmacokinetics was observed between LDP vs. DDP following rac-dropropizine. However, LDP pharmacokinetics after LDP administration (oral/IV) appeared to be different co …
Validated methods were used to quantitate LDP, DDP and rac-dropropizine.No stereoselectivity in pharmacokinetics was observed between …
Antitussive properties of levodropropizine.
Malandrino S, Melillo G, Bestetti A, Borsa M, Giuliani P, Tonon GC. Malandrino S, et al. Arzneimittelforschung. 1988 Aug;38(8):1141-3. Arzneimittelforschung. 1988. PMID: 3196407
Intravenously, it was 1/10 to 1/20 as active as codeine and comparable to dropropizine, from which it is derived, on mechanically and electrically induced coughing in rabbits and guinea-pigs. After oral administration to the guinea-pig the antitussive activity of levodropr …
Intravenously, it was 1/10 to 1/20 as active as codeine and comparable to dropropizine, from which it is derived, on mechanically and …
Enantioselective effects of levodropropizine and dropropizine on psychomotor functions in normal volunteers: a placebo-controlled, double-blind comparative study.
Gatti G, Barzaghi N, Dominijanni R, Cordaro C, Perucca E. Gatti G, et al. Drugs Exp Clin Res. 1993;19(1):33-9. Drugs Exp Clin Res. 1993. PMID: 8223138 Clinical Trial.
Levodropropizine is the l-isomer of dropropizine, a racemic drug widely used as a cough suppressant. Compared with the racemate, levodropropizine retains equal antitussive activity but exhibits considerably lower central nervous system (CNS) depressant effects in animal mo …
Levodropropizine is the l-isomer of dropropizine, a racemic drug widely used as a cough suppressant. Compared with the racemate, levo …
Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.
Staack RF, Theobald DS, Maurer HH. Staack RF, et al. Ther Drug Monit. 2004 Aug;26(4):441-9. doi: 10.1097/00007691-200408000-00015. Ther Drug Monit. 2004. PMID: 15257075 Clinical Trial.
Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chromatography-mass spectrometry (GC-MS). ...
Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl …
A comparative study of the antitussive activity of levodropropizine and dropropizine in the citric acid-induced cough model in normal subjects.
Fumagalli G, Cordaro CI, Vanasia M, Balzarotti C, Camusso L, Caiazzo G, Maghini L, Mazzocchi M, Zennaro M. Fumagalli G, et al. Drugs Exp Clin Res. 1992;18(7):303-9. Drugs Exp Clin Res. 1992. PMID: 1295724 Clinical Trial.
Levodropropizine is the levo-rotatory (S)-enantiomer of dropropizine, a racemic non-opiate antitussive agent which has been used clinically for many years. ...Since the comparative antitussive potency of the two drugs in clinical experimental models has not been evaluated, …
Levodropropizine is the levo-rotatory (S)-enantiomer of dropropizine, a racemic non-opiate antitussive agent which has been used clin …
Novel route for the resolution of both enantiomers of dropropizine by using oxime esters and supported lipases of Pseudomonas cepacia.
Salunkhe MM, Nair RV. Salunkhe MM, et al. Enzyme Microb Technol. 2001 Mar 8;28(4-5):333-338. doi: 10.1016/s0141-0229(00)00347-1. Enzyme Microb Technol. 2001. PMID: 11240188
This enzymatic acylation using oxime esters was significant as only (S)-dropropizine and (R)-dropropizine monoacetate was obtained. (R)-Dropropizine monoacetate was chemically hydrolyzed to obtain (R)-dropropizine. ...This enzymatic resolution provides …
This enzymatic acylation using oxime esters was significant as only (S)-dropropizine and (R)-dropropizine monoacetate was obta …
26 results