Structural Basis for Selective Oxidation of Phosphorylated Ethylphenols by Cytochrome P450 Monooxygenase CreJ.
Dong S, Chen J, Zhang X, Guo F, Ma L, You C, Wang X, Zhang W, Wan X, Liu SJ, Yao LS, Li S, Du L, Feng Y.
Dong S, et al.
Appl Environ Microbiol. 2021 May 11;87(11):e00018-21. doi: 10.1128/AEM.00018-21. Print 2021 May 11.
Appl Environ Microbiol. 2021.
PMID: 33712426
Free PMC article.
However, the mechanism of regio- and stereoselectivity of this chemomimetic biocatalytic system remained unclear. Here, using p- and m-ethylphenol substrates, we elucidate the CreJ-catalyzed key steps for selective oxidations. The crystal structure of CreJ in comple …
However, the mechanism of regio- and stereoselectivity of this chemomimetic biocatalytic system remained unclear. Here, using p- and m …