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1988 2
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28 results

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Page 1
Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.
Ibrahim AIM, Batlle E, Sneha S, Jiménez R, Pequerul R, Parés X, Rüngeler T, Jha V, Tuccinardi T, Sadiq M, Frame F, Maitland NJ, Farrés J, Pors K. Ibrahim AIM, et al. J Med Chem. 2022 Mar 10;65(5):3833-3848. doi: 10.1021/acs.jmedchem.1c01367. Epub 2022 Feb 25. J Med Chem. 2022. PMID: 35212533 Free PMC article.
Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer and considered a potential target for therapeutic intervention. 4-(Diethylamino)benzaldehyde (DEAB) has been extensively reported as a pan-inhibitor of ALDH iso …
Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer and considered a potential target for the …
Effect of 4-(diethylamino)benzaldehyde on ethanol metabolism in mice.
Mahmoud MI, Potter JJ, Colvin OM, Hilton J, Mezey E. Mahmoud MI, et al. Alcohol Clin Exp Res. 1993 Dec;17(6):1223-7. doi: 10.1111/j.1530-0277.1993.tb05233.x. Alcohol Clin Exp Res. 1993. PMID: 8116835
The compound 4-(diethylamino)benzaldehyde (DEAB) is a potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) in vitro and can overcome cyclophosphamide resistance in murine leukemia cells characterized by their high content of ALDH. ...
The compound 4-(diethylamino)benzaldehyde (DEAB) is a potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (A …
Development and validation of an HPLC-UV method for the analysis of methoxyamine using 4-(diethylamino)benzaldehyde as a derivatizing agent.
Liao YC, Yang S, Syu MJ, Xu Y. Liao YC, et al. J Pharm Biomed Anal. 2005 Sep 15;39(3-4):724-9. doi: 10.1016/j.jpba.2005.04.035. J Pharm Biomed Anal. 2005. PMID: 15951147
In this paper, a quantitative HPLC-UV method for MX using 4-(diethylamino)benzaldehyde (DEAB) as a derivatizing agent has been developed and validated. The studies showed that MX reacts with DEAB under acidic conditions to form protonated 4-(diethyl …
In this paper, a quantitative HPLC-UV method for MX using 4-(diethylamino)benzaldehyde (DEAB) as a derivatizing agent h …
Facile and high-yield synthesis of N-(4-diethylamino)benzyl-4-[¹¹C]methoxy-N-(p-tolyl)benzenesulfonamide as a new potential PET selective CB2 radioligand.
Gao M, Xu J, Wang M, Zheng QH. Gao M, et al. Appl Radiat Isot. 2014 Aug;90:181-6. doi: 10.1016/j.apradiso.2014.03.029. Epub 2014 Apr 5. Appl Radiat Isot. 2014. PMID: 24768996
The reference standard N-(4-diethylamino)benzyl-4-methoxy-N-(p-tolyl)benzenesulfonamide (3c) (CB2, Ki=0.5 nM; CB1, Ki=1297 nM; selectivity CB1/CB2=2594) and its corresponding precursor N-(4-diethylamino)benzyl-4-hydroxy-N-(p-tolyl)benzenesulfonamide (3d) were synthesized from …
The reference standard N-(4-diethylamino)benzyl-4-methoxy-N-(p-tolyl)benzenesulfonamide (3c) (CB2, Ki=0.5 nM; CB1, Ki=1297 nM; selectivity C …
Synthesis and structural study of organic two-photon-absorbing cycloalkanone chromophores.
Bogdanov G, Tillotson JP, Khrustalev VN, Rigin S, Timofeeva TV. Bogdanov G, et al. Acta Crystallogr C Struct Chem. 2019 Nov 1;75(Pt 11):1554-1561. doi: 10.1107/S2053229619014360. Epub 2019 Oct 30. Acta Crystallogr C Struct Chem. 2019. PMID: 31686667
The three organic two-photon-absorbing cycloalkanone chromophores 2,4-bis[4-(diethylamino)benzylidene]cyclobutanone, C(26)H(32)N(2)O (I), 2,5-bis[4-(diethylamino)benzylidene]cyclopentanone, C(27)H(34)N(2)O (II), and 2,6-bis[4-(diethylamino)benzylidene]cyclohexanone, C(28)H(36)N(2 …
The three organic two-photon-absorbing cycloalkanone chromophores 2,4-bis[4-(diethylamino)benzylidene]cyclobutanone, C(26)H(32)N(2)O (I), 2, …
Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome.
Catron MA, Howe RK, Besing GK, St John EK, Potesta CV, Gallagher MJ, Macdonald RL, Zhou C. Catron MA, et al. Brain Commun. 2022 Dec 17;5(1):fcac332. doi: 10.1093/braincomms/fcac332. eCollection 2023. Brain Commun. 2022. PMID: 36632186 Free PMC article.
Furthermore, suppression of slow-wave oscillation-related homeostatic synaptic potentiation by 4-(diethylamino)-benzaldehyde injection (i.p.) greatly attenuated spike-wave discharge incidence in heterozygous knock-in mice, suggesting that slow-wave oscillatio …
Furthermore, suppression of slow-wave oscillation-related homeostatic synaptic potentiation by 4-(diethylamino)-benzaldehyd …
Mitochondrial targeted fluorescent probe with AIE characteristics for bioimaging.
Lu X, Hou M, Xia Q, Yan C, Xu Y, Liu R. Lu X, et al. Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:129-135. doi: 10.1016/j.msec.2017.03.127. Epub 2017 Mar 18. Mater Sci Eng C Mater Biol Appl. 2017. PMID: 28532006
In this work, a new benzothiazole based mitochondrial tracker, Bth-Mito, is synthesized by with 2-benzothiazoleacetonitrile and 4-(diethylamino)-benzaldehyde. Bth-Mito is weakly fluorescent when dissolved in the good solvent but becomes highly emissive in poo …
In this work, a new benzothiazole based mitochondrial tracker, Bth-Mito, is synthesized by with 2-benzothiazoleacetonitrile and 4-( …
Differential retinoic acid sensitivity of oral and pharyngeal teeth in medaka (Oryzias latipes) supports the importance of pouch-cleft contacts in pharyngeal tooth initiation.
Larionova D, Huysseune A. Larionova D, et al. Dev Dyn. 2024 Dec;253(12):1094-1105. doi: 10.1002/dvdy.723. Epub 2024 Jun 28. Dev Dyn. 2024. PMID: 38940489 Free article.
Here, we test the hypothesis that a proper pouch-cleft contact is required for pharyngeal tooth formation in embryonic medaka, as it is in zebrafish. We used 4-[diethylamino]benzaldehyde (DEAB) to pharmacologically inhibit RA production, and thus pouch-cleft …
Here, we test the hypothesis that a proper pouch-cleft contact is required for pharyngeal tooth formation in embryonic medaka, as it is in z …
28 results