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1975 1
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23 results

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Quoted phrase not found in phrase index: "steoroids"
Page 1
Synthesis, anticancer activity and molecular docking of new quinolines, quinazolines and 1,2,4-triazoles with pyrido[2,3-d] pyrimidines.
Abu-Hashem AA, Hakami O, Amri N. Abu-Hashem AA, et al. Heliyon. 2024 Feb 29;10(5):e26735. doi: 10.1016/j.heliyon.2024.e26735. eCollection 2024 Mar 15. Heliyon. 2024. PMID: 38468950 Free PMC article.
These compounds were synthesized with high efficiency, producing yields ranging from 69% to 90%, under moderate conditions, through treating (2) or (10) with various reagents such as anthranilic acid, phosphorus oxychloride, hydrazine hydrate, formic acid, glacial acetic acid, ar …
These compounds were synthesized with high efficiency, producing yields ranging from 69% to 90%, under moderate conditions, through treating …
Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents.
Oliva P, Romagnoli R, Cacciari B, Manfredini S, Padroni C, Brancale A, Ferla S, Hamel E, Corallo D, Aveic S, Milan N, Mariotto E, Viola G, Bortolozzi R. Oliva P, et al. Pharmaceutics. 2022 Jun 2;14(6):1191. doi: 10.3390/pharmaceutics14061191. Pharmaceutics. 2022. PMID: 35745764 Free PMC article.
Two different series of fifty-two compounds, based on 3',4',5'-trimethoxyaniline (7a-ad) and variably substituted anilines (8a-v) at the 7-position of the 2-substituted-[1,2,4]triazolo [1,5-a]pyrimidine nucleus, had moderate to potent antiproliferative activity against A549, MDA- …
Two different series of fifty-two compounds, based on 3',4',5'-trimethoxyaniline (7a-ad) and variably substituted anilines (8a-v) at the 7-p …
Under pressure: Daphnia magna's responses to 4-chloroaniline exposure and climate-induced temperature rise.
Rebelo D, Antunes SC, Rodrigues S. Rebelo D, et al. Environ Sci Pollut Res Int. 2025 Oct;32(47):27263-27277. doi: 10.1007/s11356-025-37199-1. Epub 2025 Nov 24. Environ Sci Pollut Res Int. 2025. PMID: 41284156
With global warming, it is crucial to recognise that temperature changes can influence the ecotoxicity of pollutants in natural ecosystems. 4-Chloroaniline (4-CA) is an emerging contaminant due to its environmental persistence, bioaccumulation potential, and …
With global warming, it is crucial to recognise that temperature changes can influence the ecotoxicity of pollutants in natural ecosystems. …
Health risk and source assessment of semi-volatile phenols, p-chloroaniline and plasticizers in plastic packaged (sachet) drinking water.
Adjei JK, Ofori A, Megbenu HK, Ahenguah T, Boateng AK, Adjei GA, Bentum JK, Essumang DK. Adjei JK, et al. Sci Total Environ. 2021 Nov 25;797:149008. doi: 10.1016/j.scitotenv.2021.149008. Epub 2021 Jul 16. Sci Total Environ. 2021. PMID: 34303974
The mean total levels for the phenols, p-chloroaniline, and plasticizers were between 210.2 and 18,914.9, 11.2 and 18,871.0, and 21.2 and 69,834.1 ng/L respectively. The cumulative non-cancer risk (hazard quotient) and cancer risk upon exposure were computed to rang …
The mean total levels for the phenols, p-chloroaniline, and plasticizers were between 210.2 and 18,914.9, 11.2 and 18,871.0, and 21.2 and 69 …
Exposure to melamine and its derivatives and aromatic amines among pregnant women in the United States: The ECHO Program.
Choi G, Kuiper JR, Bennett DH, Barrett ES, Bastain TM, Breton CV, Chinthakindi S, Dunlop AL, Farzan SF, Herbstman JB, Karagas MR, Marsit CJ, Meeker JD, Morello-Frosch R, O'Connor TG, Pellizzari ED, Romano ME, Sathyanarayana S, Schantz S, Schmidt RJ, Watkins DJ, Zhu H, Kannan K, Buckley JP, Woodruff TJ; program collaborators for Environmental influences on Child Health Outcomes. Choi G, et al. Chemosphere. 2022 Nov;307(Pt 2):135599. doi: 10.1016/j.chemosphere.2022.135599. Epub 2022 Aug 30. Chemosphere. 2022. PMID: 36055588 Free PMC article.
Nevertheless, biomonitoring of these chemicals is lacking, particularly during pregnancy, a period of increased susceptibility to adverse health effects. OBJECTIVES: We aimed to measure melamine, melamine derivatives, and aromatic amine exposure in pregnant women across th …
Nevertheless, biomonitoring of these chemicals is lacking, particularly during pregnancy, a period of increased susceptibility to adv …
Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program.
Discenza LN, Balog A, Huang C, Moore R, Ranasinghe A, Lin TA, D'Arienzo C, Olah TV. Discenza LN, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Sep 1;1207:123305. doi: 10.1016/j.jchromb.2022.123305. Epub 2022 Jun 28. J Chromatogr B Analyt Technol Biomed Life Sci. 2022. PMID: 35839627
BMS-986205 (Linrodostat) is a small molecule inhibitor of Indoleamine 2, 3 dioxygenase (IDO) that is currently being evaluated in clinical trials for the oral treatment of advanced cancer. Initially, there were concerns regarding possible toxicity following administration, …
BMS-986205 (Linrodostat) is a small molecule inhibitor of Indoleamine 2, 3 dioxygenase (IDO) that is currently being evaluated in clinical t …
Assessment of the mutagenic potential of para-chloroaniline and aniline in the liver, spleen, and bone marrow of Big Blue® rats with micronuclei analysis in peripheral blood.
Koenig CM, Beevers C, Pant K, Young RR. Koenig CM, et al. Environ Mol Mutagen. 2018 Dec;59(9):785-797. doi: 10.1002/em.22241. Epub 2018 Sep 14. Environ Mol Mutagen. 2018. PMID: 30216547
Splenic tumors have been reported in rat cancer bioassays with para-chloroaniline (PCA) and aniline. Development of these tumors is hypothesized to be due to hematotoxicity via the formation of methemoglobin (MetHb) and not direct DNA reactivity. To evaluate the mode of ac …
Splenic tumors have been reported in rat cancer bioassays with para-chloroaniline (PCA) and aniline. Development of these tumors is h …
Bioassay of p-Chloroaniline for Possible Carcinogenicity (CAS No. 106-47-8).
National Toxicology Program. National Toxicology Program. Natl Toxicol Program Tech Rep Ser. 1979;189:1-105. Natl Toxicol Program Tech Rep Ser. 1979. PMID: 12778190 Free article.
p-Chloroaniline, a dye and chemical intermediate, was selected for bioassay by the National Cancer Institute because of the high incidence of bladder cancer observed among dye manufacturing industry workers. ...Levels of Evidence of Carcinogenicity: Male Rats: Equiv …
p-Chloroaniline, a dye and chemical intermediate, was selected for bioassay by the National Cancer Institute because of the high inci …
Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4'-sulfonyldianiline, or D & C red No. 9.
Goodman DG, Ward JM, Reichardt WD. Goodman DG, et al. J Natl Cancer Inst. 1984 Jul;73(1):265-73. J Natl Cancer Inst. 1984. PMID: 6588231
In some rats there was marked osseous metaplasia when the primary tumor metastasized to peritoneal surfaces. Other, less common, splenic neoplasms included hemangiosarcoma and hemangiopericytoma. ...
In some rats there was marked osseous metaplasia when the primary tumor metastasized to peritoneal surfaces. Other, less common, sple …
Determination of hemoglobin adducts of arylamines in humans.
Sabbioni G, Beyerbach A. Sabbioni G, et al. J Chromatogr B Biomed Appl. 1995 May 5;667(1):75-83. doi: 10.1016/0378-4347(94)00599-z. J Chromatogr B Biomed Appl. 1995. PMID: 7663688
Hemoglobin adducts are dosimeters for the internal dose and possibly for DNA modification at the site of tumor formation. In the present paper we introduce a new efficient method to quantify hemoglobin adducts. Precipitated hemoglobin was hydrolyzed in base in the presence …
Hemoglobin adducts are dosimeters for the internal dose and possibly for DNA modification at the site of tumor formation. In the pres …
23 results