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226 results

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Page 1
4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis.
Bryan DS, Stack M, Krysztofiak K, Cichoń U, Thomas DG, Surcel A, Schiffhauer ES, Beckett MA, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR. Bryan DS, et al. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22423-22429. doi: 10.1073/pnas.2014639117. Epub 2020 Aug 26. Proc Natl Acad Sci U S A. 2020. PMID: 32848073 Free PMC article.
Approaches that block this mechanical program represent new therapeutic avenues. We show that 4-hydroxyacetophenone (4-HAP) inhibits colon cancer cell adhesion, invasion, and migration in vitro and reduces the metastatic burden in an in vivo model of colon ca …
Approaches that block this mechanical program represent new therapeutic avenues. We show that 4-hydroxyacetophenone (4- …
4-Hydroxyacetophenone is an Antipigmentation Reagent via Inhibiting Tryrosinase Activity.
Guo Q, Zhang Y, Tang C, Li Q, Liu F, He Z, Jiang C, Xu J, Zhao H. Guo Q, et al. ACS Omega. 2025 Jul 30;10(31):34811-34821. doi: 10.1021/acsomega.5c03812. eCollection 2025 Aug 12. ACS Omega. 2025. PMID: 40821508 Free PMC article.
This study investigates the skin-whitening potential of 4-Hydroxyacetophenone (4-HAP), a compound commonly used as a preservative in cosmetics. ...
This study investigates the skin-whitening potential of 4-Hydroxyacetophenone (4-HAP), a compound commonly used as a pr …
Anti-Inflammatory Activity of 3, 5-Diprenyl-4-hydroxyacetophenone Isolated from Ageratina pazcuarensis.
Rojas-Jiménez S, Pérez-Gutiérrez MS, Sánchez-Mendoza E, Martínez-Casares RM, Campos-Xolalpa N, Valladares-Cisneros MG, Salinas-Sánchez DO. Rojas-Jiménez S, et al. Int J Mol Sci. 2022 Nov 30;23(23):15012. doi: 10.3390/ijms232315012. Int J Mol Sci. 2022. PMID: 36499338 Free PMC article.
Plants are an important source of active anti-inflammatory compounds. The compound 3, 5-diprenyl-4-hydroxyacetophenone (DHAP) was isolated from the dichloromethane extract of the aerial parts of Ageratina pazcuarensis by chromatography and identified by spectroscopi …
Plants are an important source of active anti-inflammatory compounds. The compound 3, 5-diprenyl-4-hydroxyacetophenone (DHAP) …
4-Hydroxyacetophenone-induced choleresis in rats is mediated by the Mrp2-dependent biliary secretion of its glucuronide conjugate.
Mahagita C, Tanphichai K, Suksamrarn A, Ballatori N, Piyachaturawat P. Mahagita C, et al. Pharm Res. 2006 Nov;23(11):2603-10. doi: 10.1007/s11095-006-9097-z. Epub 2006 Sep 29. Pharm Res. 2006. PMID: 17009103
PURPOSE: The present study examined the underlying mechanism by which 4-hydroxyacetophenone (4-HA), a bioactive compound found in several medicinal herbs, exerts its potent stimulatory effects on hepatic bile secretion. ...HPLC analysis revealed that a single …
PURPOSE: The present study examined the underlying mechanism by which 4-hydroxyacetophenone (4-HA), a bioactive compoun …
Elucidation of the 4-hydroxyacetophenone catabolic pathway in Pseudomonas fluorescens ACB.
Moonen MJ, Kamerbeek NM, Westphal AH, Boeren SA, Janssen DB, Fraaije MW, van Berkel WJ. Moonen MJ, et al. J Bacteriol. 2008 Aug;190(15):5190-8. doi: 10.1128/JB.01944-07. Epub 2008 May 23. J Bacteriol. 2008. PMID: 18502868 Free PMC article.
The catabolism of 4-hydroxyacetophenone in Pseudomonas fluorescens ACB is known to proceed through the intermediate formation of hydroquinone. ...The P. fluorescens ACB genes involved in 4-hydroxyacetophenone utilization were cloned and characterized. …
The catabolism of 4-hydroxyacetophenone in Pseudomonas fluorescens ACB is known to proceed through the intermediate formation …
Extraction of 4'-hydroxyacetophenone and caudatin from Cynanchum auriculatum flowers using enzymolysis-green surfactant assisted homogenate ultrasound method.
Cui G, Wen Y, Yang L, Liu X, Wu X, Shen M, Kang Y, Yao L. Cui G, et al. Food Chem. 2025 Oct 1;488:144923. doi: 10.1016/j.foodchem.2025.144923. Epub 2025 May 26. Food Chem. 2025. PMID: 40446658
An efficient and green enzymolysis-surfactant-assisted homogenate ultrasound method (ESHU) was used to extract of 4'-hydroxyacetophenone and caudatin from Cynanchum auriculatum flowers. After optimizing ESHU using a mathematical design model, the yields of 4' …
An efficient and green enzymolysis-surfactant-assisted homogenate ultrasound method (ESHU) was used to extract of 4'-hydroxyacetop …
4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB. A novel flavoprotein catalyzing Baeyer-Villiger oxidation of aromatic compounds.
Kamerbeek NM, Moonen MJ, Van Der Ven JG, Van Berkel WJ, Fraaije MW, Janssen DB. Kamerbeek NM, et al. Eur J Biochem. 2001 May;268(9):2547-57. doi: 10.1046/j.1432-1327.2001.02137.x. Eur J Biochem. 2001. PMID: 11322873 Free article.
A novel flavoprotein that catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate, was purified to homogeneity from Pseudomonas fluorescens ACB. Characterization of the purified enzyme showed that 4-hydroxyacetophenone …
A novel flavoprotein that catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate, was pur …
Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14.
Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli KT, Herbig M, Otto O, West-Foyle H, Jacobi A, Kräter M, Plak K, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN. Surcel A, et al. Cancer Res. 2019 Sep 15;79(18):4665-4678. doi: 10.1158/0008-5472.CAN-18-3131. Epub 2019 Jul 29. Cancer Res. 2019. PMID: 31358530 Free PMC article.
Here, the low abundant protein MYH14 promoted metastatic behavior and could be exploited with 4-hydroxyacetophenone (4-HAP), which increased MYH14 assembly, stiffening cells. As a result, 4-HAP decreased dissemination, induced cortical actin belts in spheroid …
Here, the low abundant protein MYH14 promoted metastatic behavior and could be exploited with 4-hydroxyacetophenone (4- …
Conversion of 4-hydroxyacetophenone into 4-phenyl acetate by a flavin adenine dinucleotide-containing Baeyer-Villiger-type monooxygenase.
Tanner A, Hopper DJ. Tanner A, et al. J Bacteriol. 2000 Dec;182(23):6565-9. doi: 10.1128/JB.182.23.6565-6569.2000. J Bacteriol. 2000. PMID: 11073896 Free PMC article.
It had the characteristics of a Baeyer-Villiger-type monooxygenase and converted its substrate, 4-hydroxyacetophenone, into 4-hydroxyphenyl acetate with the consumption of one molecule of oxygen and oxidation of one molecule of NADPH per molecule of substrate. ...Th …
It had the characteristics of a Baeyer-Villiger-type monooxygenase and converted its substrate, 4-hydroxyacetophenone, into 4- …
4-Ethylphenol metabolism by Aspergillus fumigatus.
Jones KH, Trudgill PW, Hopper DJ. Jones KH, et al. Appl Environ Microbiol. 1994 Jun;60(6):1978-83. doi: 10.1128/aem.60.6.1978-1983.1994. Appl Environ Microbiol. 1994. PMID: 8031091 Free PMC article.
The initial step involves hydroxylation of the methylene group of 4-ethylphenol to form 1-(4'-hydroxyphenyl)ethanol, followed by oxidation to 4-hydroxyacetophenone. The hydroxylase was NADPH and oxygen dependent, which is a characteristic of a monooxygenase type of …
The initial step involves hydroxylation of the methylene group of 4-ethylphenol to form 1-(4'-hydroxyphenyl)ethanol, followed by oxidation t …
226 results