Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1968 1
1972 1
1976 1
1977 1
1980 4
1981 7
1982 7
1983 5
1984 9
1985 8
1986 5
1987 8
1988 8
1989 7
1990 10
1991 10
1992 8
1993 8
1994 6
1995 7
1996 2
1997 11
1998 10
1999 8
2000 8
2001 5
2002 10
2003 8
2004 18
2005 3
2006 11
2007 13
2008 12
2009 11
2010 21
2011 16
2012 7
2013 9
2014 10
2015 11
2016 11
2017 6
2018 10
2019 12
2020 11
2021 8
2022 13
2023 12
2024 19
2025 13
2026 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

413 results

Results by year

Filters applied: . Clear all
Page 1
Treatment of Solar Lentigines: A Systematic Review of Clinical Trials.
Mardani G, Nasiri MJ, Namazi N, Farshchian M, Abdollahimajd F. Mardani G, et al. J Cosmet Dermatol. 2025 Apr;24(4):e70133. doi: 10.1111/jocd.70133. J Cosmet Dermatol. 2025. PMID: 40145274 Free PMC article.
The most common effective topical treatment was a combination of mequinol 2% and tretinoin 0.01%, achieving efficacy rates between 52.6% and over 80%, particularly for facial lesions. ...
The most common effective topical treatment was a combination of mequinol 2% and tretinoin 0.01%, achieving efficacy rates between 52 …
Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color.
Davis EC, Callender VD. Davis EC, et al. J Clin Aesthet Dermatol. 2010 Jul;3(7):20-31. J Clin Aesthet Dermatol. 2010. PMID: 20725554 Free PMC article.
Other depigmenting agents include retinoids, mequinol, ascorbic acid, niacinamide, N-acetyl glucosamine, and soy with a number of emerging therapies on the horizon. ...
Other depigmenting agents include retinoids, mequinol, ascorbic acid, niacinamide, N-acetyl glucosamine, and soy with a number of eme …
Depigmentation Therapies for Vitiligo.
Grimes PE, Nashawati R. Grimes PE, et al. Dermatol Clin. 2017 Apr;35(2):219-227. doi: 10.1016/j.det.2016.11.010. Dermatol Clin. 2017. PMID: 28317530 Review.
Permanent topical therapies used for depigmentation include monobenzyl ether of hydroquinone, 4-methoxyphenol, and 88% phenol. Physical modalities, such as cryotherapy and lasers, are also being used successfully....
Permanent topical therapies used for depigmentation include monobenzyl ether of hydroquinone, 4-methoxyphenol, and 88% phenol. …
Three (E)-2-[(bromophenyl)iminomethyl]-4-methoxyphenols.
Ozek A, Albayrak C, Odabaşoğlu M, Büyükgüngör O. Ozek A, et al. Acta Crystallogr C. 2007 Mar;63(Pt 3):o177-80. doi: 10.1107/S0108270107003241. Epub 2007 Feb 17. Acta Crystallogr C. 2007. PMID: 17339725
The title compounds, (E)-2-[(2-bromophenyl)iminomethyl]-4-methoxyphenol, C(14)H(12)BrNO(2), (I), (E)-2-[(3-bromophenyl)iminomethyl]-4-methoxyphenol, C(14)H(12)BrNO(2), (II), and (E)-2-[(4-bromophenyl)iminomethyl]-4-methoxyphenol, C(14)H(1 …
The title compounds, (E)-2-[(2-bromophenyl)iminomethyl]-4-methoxyphenol, C(14)H(12)BrNO(2), (I), (E)-2-[(3-bromophenyl)iminome …
Treatment of hyperpigmentation.
Rossi AM, Perez MI. Rossi AM, et al. Facial Plast Surg Clin North Am. 2011 May;19(2):313-24. doi: 10.1016/j.fsc.2011.05.010. Facial Plast Surg Clin North Am. 2011. PMID: 21763992
The combination of 2% 4-hydroxyanisole (Mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies.
Fleischer AB Jr, Schwartzel EH, Colby SI, Altman DJ. Fleischer AB Jr, et al. J Am Acad Dermatol. 2000 Mar;42(3):459-67. doi: 10.1016/s0190-9622(00)90219-6. J Am Acad Dermatol. 2000. PMID: 10688717 Clinical Trial.
A tyrosinase inhibitor in use in Europe, 4-hydroxyanisole (Mequinol), and the retinoid tretinoin have been used singly as depigmenting agents. OBJECTIVE: The efficacy and safety of the combination product of 2% 4-hydroxyanisole (4HA [mequinol]) /0.01% tretinoin solu …
A tyrosinase inhibitor in use in Europe, 4-hydroxyanisole (Mequinol), and the retinoid tretinoin have been used singly as depigmentin …
4-Hydroxyanisole: human pharmacokinetics.
Belcher HJ, Barsted CG, Dawson CM. Belcher HJ, et al. Pigment Cell Res. 1990 Dec;3(6):306-9. doi: 10.1111/j.1600-0749.1990.tb00302.x. Pigment Cell Res. 1990. PMID: 2101930
Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats.
Asakawa E, Hirose M, Hagiwara A, Takahashi S, Ito N. Asakawa E, et al. Int J Cancer. 1994 Jan 2;56(1):146-52. doi: 10.1002/ijc.2910560126. Int J Cancer. 1994. PMID: 8262672
The carcinogenic potentials of 4-methoxyphenol (4-MP) and 4-methylcatechol (4-MC), phenolic compounds which are structurally similar to the known forestomach carcinogen BHA and the glandular stomach carcinogen catechol respectively, and cause considerably enh …
The carcinogenic potentials of 4-methoxyphenol (4-MP) and 4-methylcatechol (4-MC), phenolic compounds which are structu …
Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity.
Fujisawa S, Atsumi T, Kadoma Y, Sakagami H. Fujisawa S, et al. Toxicology. 2002 Aug 1;177(1):39-54. doi: 10.1016/s0300-483x(02)00194-4. Toxicology. 2002. PMID: 12126794 Review.
To clarify the possible link between radicals and the cytotoxicity of eugenol-related compounds, 2-allyl-4-X-phenols (2-allyl-4-chlorophenol (1), 2-allyl-4-phenylphenol (2), 2-allyl-4-methoxyphenol (3), 2-allyl-4-acetylphenol (4), 2-allyl-4-nitrophenol (5), 2-allyl- …
To clarify the possible link between radicals and the cytotoxicity of eugenol-related compounds, 2-allyl-4-X-phenols (2-allyl-4-chlorophenol …
Mequinol 2%/tretinoin 0.01% solution: an effective and safe alternative to hydroquinone 3% in the treatment of solar lentigines.
Jarratt M. Jarratt M. Cutis. 2004 Nov;74(5):319-22. Cutis. 2004. PMID: 15605971 Clinical Trial.
A new topical solution containing 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% (Solage) was compared with its active components, its vehicle, and hydroquinone (HQ) 3% in the treatment of solar lentigines. ...The proportion of subjects achieving clinical success on the fa …
A new topical solution containing 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% (Solage) was compared with its active components, it …
413 results