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N-(4-(6-(Isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N-methyl-4-[11C]methylbenzamide.
Leung K. Leung K. 2013 Feb 19 [updated 2013 May 2]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2013 Feb 19 [updated 2013 May 2]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 23638494 Free Books & Documents. Review.
N-(4-(6-(Isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N-methyl-4-methylbenzamide (ITDM) was shown to be a selective mGluR1 antagonist with nanomolar affinity (K(i) = 13.6 nM), with little inhibition of mGluR5 (9). ...
N-(4-(6-(Isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N-methyl-4-methylbenzamide (ITDM) was shown to be a selective mGluR1 …
N-(2,3-Dimethyl-phen-yl)-4-methylbenzamide.
Rodrigues VZ, Herich P, Gowda BT, Kožíšek J. Rodrigues VZ, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2463. doi: 10.1107/S1600536811034490. Epub 2011 Aug 27. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 22059024 Free PMC article.
Histone deacetylase inhibitor RG2833 has therapeutic potential for Alzheimer's disease in females.
Ndukwe K, Serrano PA, Rockwell P, Xie L, Figueiredo-Pereira M. Ndukwe K, et al. bioRxiv [Preprint]. 2023 Dec 29:2023.12.26.573348. doi: 10.1101/2023.12.26.573348. bioRxiv. 2023. Update in: J Alzheimers Dis. 2025 Mar;104(1):173-190. doi: 10.1177/13872877251314777. PMID: 38234827 Free PMC article. Updated. Preprint.
Through our computational studies, we predicted that the investigational drug RG2833 (N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide) has repurposing potential for Alzheimer's. RG2833 is a histone deacetylase HDAC1/3 inhibitor that is orally bioavailable and pe …
Through our computational studies, we predicted that the investigational drug RG2833 (N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbe …
Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J, Filla S, Freed E, Hu H, Huszar D, Jayaraman M, Lawson D, Lewis PM, Nadella MV, Oza V, Padmanilayam M, Pontz T, Ronco L, Russell D, Whitston D, Zheng X. Theoclitou ME, et al. J Med Chem. 2011 Oct 13;54(19):6734-50. doi: 10.1021/jm200629m. Epub 2011 Sep 7. J Med Chem. 2011. PMID: 21899292
Structure-activity relationship analysis identified (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), from a series of novel kinesin spindle protein (KSP) inhibitors, as exhibiting bo …
Structure-activity relationship analysis identified (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)- …
Synthesis and biological evaluation of benzamide-chalcone hybrids as potential c-Met kinase and COX-2 inhibitors.
Bhojwani H, Begwani K, Bhor V, Bedi P, Balasinor N, Raut S, Joshi U. Bhojwani H, et al. Arch Pharm (Weinheim). 2023 May;356(5):e2200405. doi: 10.1002/ardp.202200405. Epub 2023 Feb 8. Arch Pharm (Weinheim). 2023. PMID: 36752183
Chalcone and benzamide moieties were combined using molecular hybridization to assess their potential as c-Met kinase and COX-2 inhibitors. 4-Methylbenzamide and 4-chlorobenzamide chalcone analogs were synthesized, characterized, and evaluated for antiproliferative …
Chalcone and benzamide moieties were combined using molecular hybridization to assess their potential as c-Met kinase and COX-2 inhibitors. …
Design, Synthesis, Docking Studies, and Biological Evaluation of Novel 2-Hydroxyacetophenone Derivatives as Anti-HIV-1 Agents.
Oliaie SS, Safakish M, Roudsari RV, Mahboubi-Rabbani M, Hajimahdi Z, Zarghi A. Oliaie SS, et al. Curr HIV Res. 2023;21(5):290-300. doi: 10.2174/011570162X261377231107110447. Curr HIV Res. 2023. PMID: 37990893
The most potent compounds substituting with 4-fluorobenzamide (compound 7) and 4-methylbenzamide (compound 9) rings inhibited the HIV-1 replication by EC(50) values of 40 and 45 mumu, respectively. ...
The most potent compounds substituting with 4-fluorobenzamide (compound 7) and 4-methylbenzamide (compound 9) rings inhibited …
Synthesis, experimental spectra (IR & Raman and NMR), vibrational analysis and theoretical DFT investigations of N-(5-(4-methylbenzoyl)-2-oxo-4-(4-methylphenyl)pyrimidine-1(2H)-yl)-4-methylbenzamide.
Aydın L, Şahan E, Önal Z, Özpozan T. Aydın L, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Aug 14;129:22-34. doi: 10.1016/j.saa.2014.02.176. Epub 2014 Mar 20. Spectrochim Acta A Mol Biomol Spectrosc. 2014. PMID: 24835751
The title molecule, N-(5-(4-methylbenzoyl)-2-oxo-4-(4-methylphenyl)pyrimidine-1(2H)-yl)-4-methylbenzamide (C27H23N3O3), was synthesized and characterized by elemental analysis, IR, Raman, (1)H and (13)C NMR spectral data. ...
The title molecule, N-(5-(4-methylbenzoyl)-2-oxo-4-(4-methylphenyl)pyrimidine-1(2H)-yl)-4-methylbenzamide (C27H23N3O3), was sy …
4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-α and CXCL1 production and exhibits activity in models of pain and inflammation.
Melo ISF, Rodrigues FF, Costa SOAM, Braga AV, Morais MÍ, Vaz JA, Neto LS, Galvão I, Modolo LV, Amaral FA, Oliveira RB, de Fátima Â, Coelho MM, Machado RR. Melo ISF, et al. Eur J Pharmacol. 2019 Aug 5;856:172404. doi: 10.1016/j.ejphar.2019.172404. Epub 2019 May 24. Eur J Pharmacol. 2019. PMID: 31132352 Free article.
Mechanical allodynia and paw edema induced by carrageenan were not inhibited by the 4-MBC oxo analogue (p-toluamide). In summary, 4-MBC, an H(2)S releasing thiobenzamide, exhibits antinociceptive and anti-inflammatory activities. ...
Mechanical allodynia and paw edema induced by carrageenan were not inhibited by the 4-MBC oxo analogue (p-toluamide). In summa …
Structural properties of benzimidazole cavitand and its selective recognition toward 4-methylbenzamide over 4-methylanilide.
Choi HJ, Park YS, Song J, Youn SJ, Kim HS, Kim SH, Koh K, Paek K. Choi HJ, et al. J Org Chem. 2005 Jul 22;70(15):5974-81. doi: 10.1021/jo0506478. J Org Chem. 2005. PMID: 16018693
However, an isomorphic 4-methylanilide guest such as N-4-tolylacetamide 8 cannot be recognized in the concave cavity of 5. This high selectivity toward 4-methylbenzamide over 4-methylanilide seems attributable to the hydrogen-binding interaction between the NH proto …
However, an isomorphic 4-methylanilide guest such as N-4-tolylacetamide 8 cannot be recognized in the concave cavity of 5. This high selecti …
Major isozymes of rat liver microsomal cytochrome P-450 involved in the N-oxidation of N-isopropyl-alpha-(2-methylazo)-p-toluamide, the azo derivative of procarbazine.
Prough RA, Brown MI, Dannan GA, Guengerich FP. Prough RA, et al. Cancer Res. 1984 Feb;44(2):543-8. Cancer Res. 1984. PMID: 6692359
The product ratio [N-isopropyl-alpha-(methyl-ONN-azoxy)-p-toluamide formation relative to N-isopropyl-alpha-(methyl-NNO-azoxy)-p-toluamide formation] obtained with cytochrome P-450PB-C was nearly identical to those values obtained with liver microsomes …
The product ratio [N-isopropyl-alpha-(methyl-ONN-azoxy)-p-toluamide formation relative to N-isopropyl-alpha-(methyl-NNO-azoxy) …
79 results