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Quoted phrase not found in phrase index: "6,9a-dimethyl-3-methylidene-3a,4,5,6,6a,9b-hexahydroazuleno[7,8-d]furan-2,9-dione"
Page 1
The molecular mechanism of ambrosin-induced cytotoxicity of human breast cancer and bladder cancer cells.
El-Sawy L, Rubin JR, Broses L, Patsalis C, Henderson ML, Wilson SJ, Glase SA, Munson KA, Hiles GL, Cates A, Emamdjomeh A, Chou A, Farber J, Kampf JW, Magnuson B, Liebert M, Paulsen MT, Van Golen K, Ljungman M, Bankhead A 3rd, Palmbos PL, Day KC, Day ML. El-Sawy L, et al. J Biol Chem. 2025 Sep;301(9):110531. doi: 10.1016/j.jbc.2025.110531. Epub 2025 Aug 5. J Biol Chem. 2025. PMID: 40754248 Free PMC article.
Ambrosin also inhibited bladder cancer and breast cancer stem cell growth as non-adherent tumor spheroids. ...Ambrosin exhibited antagonistic activity against EGFR tyrosine kinase and RhoC GTPase. Further studies showed that ambrosin inhibited EGFR auto-phosp …
Ambrosin also inhibited bladder cancer and breast cancer stem cell growth as non-adherent tumor spheroids. ...Ambrosin exhibit …
Trypanocidal and toxicological assessment in vitro and in silico of three sesquiterpene lactones from Asteraceae plant species.
Sepúlveda-Robles O, Espinoza-Gutiérrez B, Gomez-Verjan JC, Guzmán-Gutiérrez SL, De Ita M, Silva-Miranda M, Espitia-Pinzón CI, Fernández-Ramírez F, Herrera-Salazar A, Mata-Rocha M, Ortega-Hernández A, Reyes-Chilpa R. Sepúlveda-Robles O, et al. Food Chem Toxicol. 2019 Mar;125:55-61. doi: 10.1016/j.fct.2018.12.023. Epub 2018 Dec 18. Food Chem Toxicol. 2019. PMID: 30572063
We report the effect of the Sesquiterpene Lactones Ambrosin, Incomptine B and Glaucolide E against seven strains of Trypanosoma cruzi, the etiological agent of Chagas Disease. ...We evaluated by flow cytometry the viability of epimastigotes. Ambrosin was the most ef …
We report the effect of the Sesquiterpene Lactones Ambrosin, Incomptine B and Glaucolide E against seven strains of Trypanosoma cruzi …
Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative.
Sotillo WS, Villagomez R, Smiljanic S, Huang X, Malakpour A, Kempengren S, Rodrigo G, Almanza G, Sterner O, Oredsson S. Sotillo WS, et al. PLoS One. 2017 Sep 1;12(9):e0184304. doi: 10.1371/journal.pone.0184304. eCollection 2017. PLoS One. 2017. PMID: 28863191 Free PMC article.
All compounds inhibited cell proliferation; however, damsin and ambrosin were toxic at single-digit micromolar ranges, while higher concentrations were required for coronopilin and dindol-01. ...Treatment with damsin and ambrosin decreased the CSC subpopulation and …
All compounds inhibited cell proliferation; however, damsin and ambrosin were toxic at single-digit micromolar ranges, while higher c …
Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-gamma Signaling.
Kabel AM, Atef A, Borg HM, El-Sheikh AAK, Al Khabbaz HJ, Arab HH, Estfanous RS. Kabel AM, et al. Pharmaceuticals (Basel). 2022 May 13;15(5):600. doi: 10.3390/ph15050600. Pharmaceuticals (Basel). 2022. PMID: 35631426 Free PMC article.
In addition, each ambrosin or perindopril alone or in combination inhibits apoptosis and augments the mediators of autophagy in DSS-treated mice. ...Interestingly, the most remarkable effects are those encountered with the perindopril/ambrosin combination compared t …
In addition, each ambrosin or perindopril alone or in combination inhibits apoptosis and augments the mediators of autophagy in DSS-t …
Ambrosin sesquiterpene lactone exerts selective and potent anticancer effects in drug-resistant human breast cancer cells (MDA-MB-231) through mitochondrial mediated apoptosis, ROS generation and targeting Akt/beta-Catenin signaling pathway.
Fan S, Cui Y, Hu Z, Wang W, Jiang W, Xu H. Fan S, et al. J BUON. 2020 Sep-Oct;25(5):2221-2227. J BUON. 2020. PMID: 33277839 Free article.
The present study was thus designed to explore in vitro the antitumor effects of ambrosin sesquiterpene lactone against human drug-resistant breast cancer cells (MDA-MB-231). ...Ambrosin also caused remarkable changes in the morphology and suppressed the colony form …
The present study was thus designed to explore in vitro the antitumor effects of ambrosin sesquiterpene lactone against human drug-re …
Evaluation of selected natural sesquiterpenes as sensitizing agents of β-lactam-resistant bacterial strains.
Cruz-Martínez YR, Hernández-Delgado T, Valencia I, Nieto-Camacho A, Ramírez-Apan MT, Espinosa-García FJ, Delgado G. Cruz-Martínez YR, et al. J Appl Microbiol. 2024 Jan 2;135(1):lxad315. doi: 10.1093/jambio/lxad315. J Appl Microbiol. 2024. PMID: 38140942
METHODS AND RESULTS: The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of beta-lactams cefuroxime (CEFM) and cefepime (CPM) against Staphylococcus aureus 23MR and Escherichia coli 82MR strains in the absence and presence of subinhibit …
METHODS AND RESULTS: The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of beta-lactams cefurox …
Ambrosin, a potent NF-kappabeta inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin.
Khalil MNA, Choucry MA, El Senousy AS, Hassan A, El-Marasy SA, El Awdan SA, Omar FA. Khalil MNA, et al. PLoS One. 2019 Jul 5;14(7):e0219378. doi: 10.1371/journal.pone.0219378. eCollection 2019. PLoS One. 2019. PMID: 31276550 Free PMC article.
The current work aims to assess the efficacy of ambrosin as a possible remedy for AD. In silico studies showed that bioavailability and BBB permeability could be favorable for ambrosin over curcumin. ...Curcumin and ambrosin (10 mg/kg) inhibited the upsurge o …
The current work aims to assess the efficacy of ambrosin as a possible remedy for AD. In silico studies showed that bioavailability a …
Synthesis and cytotoxicity of water-soluble ambrosin prodrug candidates.
Hejchman E, Haugwitz RD, Cushman M. Hejchman E, et al. J Med Chem. 1995 Aug 18;38(17):3407-10. doi: 10.1021/jm00017a025. J Med Chem. 1995. PMID: 7650694
The potential therapeutic application of the naturally occurring, cytotoxic pseudoguaianolide sesquiterpene lactone ambrosin is limited by its aqueous insolubility. A number of water-soluble ambrosin derivatives have therefore been prepared for potential use as prod …
The potential therapeutic application of the naturally occurring, cytotoxic pseudoguaianolide sesquiterpene lactone ambrosin is limit …
Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells.
Saeed ME, Abdelgadir H, Sugimoto Y, Khalid HE, Efferth T. Saeed ME, et al. J Ethnopharmacol. 2015 Nov 4;174:644-58. doi: 10.1016/j.jep.2015.07.005. Epub 2015 Jul 10. J Ethnopharmacol. 2015. PMID: 26165828
Microarray-based mRNA expression profiling, COMPARE, and hierarchical cluster analyses were applied to identify, which genes correlate with sensitivity or resistance to ambrosin, the main constituent of the most active extract Ambrosia maritima. RESULTS: The results of the …
Microarray-based mRNA expression profiling, COMPARE, and hierarchical cluster analyses were applied to identify, which genes correlate with …
Toxicity and mutagenicity of the molluscicidal plant Ambrosia maritima L.
Alard F, Stievenart C, Vanparys P, Thilemans L, Geerts S. Alard F, et al. Drug Chem Toxicol. 1991;14(4):353-73. doi: 10.3109/01480549109011639. Drug Chem Toxicol. 1991. PMID: 1811958
Using an aqueous extract of the plant material of A. maritima or using ambrosin, one of the active molluscicidal components of the plant, no mutagenic activity could be detected in the S. typhimurium strains TA97, TA 98, TA1538, TA100 and TA1535....
Using an aqueous extract of the plant material of A. maritima or using ambrosin, one of the active molluscicidal components of the pl …
31 results