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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 1
2002 1
2003 3
2004 6
2005 10
2006 12
2007 27
2008 34
2009 28
2010 31
2011 28
2012 37
2013 38
2014 42
2015 49
2016 40
2017 58
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2020 83
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2022 43
2023 50
2024 24

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729 results

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Page 1
Intron retention in PI-PLC γ1 mRNA as a key mechanism affecting MMP expression in human primary fibroblast-like synovial cells.
Mariano A, Ammendola S, Migliorini A, Leopizzi M, Raimondo D, Scotto d'Abusco A. Mariano A, et al. Cell Biochem Funct. 2024 Jul;42(5):e4091. doi: 10.1002/cbf.4091. Cell Biochem Funct. 2024. PMID: 38973151
The decrease of PI-PLC gamma1 was associated with the decrease of metalloprotease-3 (MMP-3), and MMP-13, and ADAMTS-5 after HPE treatment. The altered expression of MMPs is a hallmark of the onset and progression of OA, thus substances able to decrease their express …
The decrease of PI-PLC gamma1 was associated with the decrease of metalloprotease-3 (MMP-3), and MMP-13, and ADAMTS-5 after HP …
Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection.
Yu M, Park C, Son YB, Jo SE, Jeon SH, Kim YJ, Han SB, Hong JT, Son DJ. Yu M, et al. Nutrients. 2024 Jun 14;16(12):1885. doi: 10.3390/nu16121885. Nutrients. 2024. PMID: 38931240 Free PMC article.
ESM further attenuates the induction of protein expression for cartilage-degrading enzymes like matrix metalloproteinase (MMPs) 3 and 13, and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), in the late-stage. In addition, MIA-induced red …
ESM further attenuates the induction of protein expression for cartilage-degrading enzymes like matrix metalloproteinase (MMPs) 3 and 13, an …
Effects of human umbilical cord mesenchymal stem cell-derived exosomes in the rat osteoarthritis models.
Yang H, Zhou Y, Ying B, Dong X, Qian Q, Gao S. Yang H, et al. Stem Cells Transl Med. 2024 Jun 24:szae031. doi: 10.1093/stcltm/szae031. Online ahead of print. Stem Cells Transl Med. 2024. PMID: 38913985 Free article.
Exosome treatment significantly downregulated the expression of MMP-13 and ADAMTS-5 in chondrocytes stimulated by IL-1beta, and upregulated collagen II expression. ...
Exosome treatment significantly downregulated the expression of MMP-13 and ADAMTS-5 in chondrocytes stimulated by IL-1beta, an …
Diosmetin ameliorates osteoarthritic inflammation in vivo and ECM macromolecules degradation in interleukin-1β-stimulated murine chondrocytes through the Nrf2/NF-κB pathway.
Qian L, Li C, Liu H, Zhou H, Tan T. Qian L, et al. Folia Histochem Cytobiol. 2024 Jun 24. doi: 10.5603/fhc.100071. Online ahead of print. Folia Histochem Cytobiol. 2024. PMID: 38912570 Free article.
RESULTS: Diosmetin suppressed the expression of iNOS, COX-2, PGE2, nitrite, TNF-alpha, IL-6, MMP-13, and ADAMTS-5 induced by IL-1beta in chondrocytes. The expression of p-p65, p-IkappaBalpha, and nuclear p65 was decreased whereas that of Nrf2 and HO-1 increased by d …
RESULTS: Diosmetin suppressed the expression of iNOS, COX-2, PGE2, nitrite, TNF-alpha, IL-6, MMP-13, and ADAMTS-5 induced by I …
Luteolin regulating synthesis and catabolism of osteoarthritis chondrocytes via activating autophagy.
Li Y, Ding Z, Liu F, Li S, Huang W, Zhou S, Han Y, Liu L, Li Y, Yin Z. Li Y, et al. Heliyon. 2024 May 21;10(11):e31028. doi: 10.1016/j.heliyon.2024.e31028. eCollection 2024 Jun 15. Heliyon. 2024. PMID: 38882274 Free PMC article.
Previous studies have demonstrated that luteolin, a flavonoid present in Chinese herbal medicine, can activate autophagy and reduce the expression of MMP1 and ADAMTS-5. This study utilized an in vitro osteoarthritis model with chondrocytes stimulated by IL-1beta, tr …
Previous studies have demonstrated that luteolin, a flavonoid present in Chinese herbal medicine, can activate autophagy and reduce the expr …
Biomechanism of abnormal stress on promoting osteoarthritis of temporomandibular joint through Piezo1 ion channel.
Li MJ, Li CX, Li JY, Gong ZC, Shao B, Zhou YC, Xu YJ, Jia MY. Li MJ, et al. J Oral Rehabil. 2024 Jun 14. doi: 10.1111/joor.13777. Online ahead of print. J Oral Rehabil. 2024. PMID: 38873703

As applied FFSS escalated (4, 8 and 12 dyn/cm(2)), the expression levels of Piezo1, ADAMTS-5, MMP-13 and Col-X gradually increased, compared with the non-FFSS group (p < .05). Administering Piezo1 ion channel inhibitor to chondrocytes beforehand, it was observed

As applied FFSS escalated (4, 8 and 12 dyn/cm(2)), the expression levels of Piezo1, ADAMTS-5, MMP-13 and Col-X gradually incre …
Serum ARGS-aggrecan in a phase 2 clinical trial targeting osteoarthritis.
Larsson S, Lalande A, Stefan Lohmander L, Soret P, Bernard K, Pueyo M, Struglics A. Larsson S, et al. Osteoarthritis Cartilage. 2024 Jun 9:S1063-4584(24)01255-X. doi: 10.1016/j.joca.2024.06.003. Online ahead of print. Osteoarthritis Cartilage. 2024. PMID: 38862084 Free article.
OBJECTIVE: To monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthrit …
OBJECTIVE: To monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disint …
Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophy.
Liu H, Davis T, Duran-Ortiz S, Martino T, Erdely A, Profio S, Osipov B, Loots GG, Berryman DE, O'Connor PM, Kopchick JJ, Zhu S. Liu H, et al. Geroscience. 2024 Jun 3. doi: 10.1007/s11357-024-01230-z. Online ahead of print. Geroscience. 2024. PMID: 38831184
Joint sections were also stained for the chondrocyte hypertrophy marker, COLX, and the cartilage degeneration marker, ADAMTS-5, using immunohistochemistry. Compared to WT mice, GHR(-/-) mice had remarkably smooth articular joint surfaces and an even distribution of …
Joint sections were also stained for the chondrocyte hypertrophy marker, COLX, and the cartilage degeneration marker, ADAMTS-5
Sipeimine ameliorates osteoarthritis progression by suppression of NLRP3 inflammasome-mediated pyroptosis through inhibition of PI3K/AKT/NF-κB pathway: An in vitro and in vivo study.
Fang Y, Lou C, Lv J, Zhang C, Zhu Z, Hu W, Chen H, Sun L, Zheng W. Fang Y, et al. J Orthop Translat. 2024 May 9;46:1-17. doi: 10.1016/j.jot.2024.04.004. eCollection 2024 May. J Orthop Translat. 2024. PMID: 38765604 Free PMC article.
Besides, Sip counteracted the degradation of collagen-II and aggrecan within the ECM and the expression of MMP-13 and ADAMTS-5 mediated by LPS. The safeguarding effects of Sip were ascribed to its inhibition of PI3K/AKT/NF-kappaB pathway and NLRP3 inflammasome media …
Besides, Sip counteracted the degradation of collagen-II and aggrecan within the ECM and the expression of MMP-13 and ADAMTS-5
New therapeutic strategies in osteoarthritis.
Siddiq MAB, Oo WM, Hunter DJ. Siddiq MAB, et al. Joint Bone Spine. 2024 Apr 27;91(6):105739. doi: 10.1016/j.jbspin.2024.105739. Online ahead of print. Joint Bone Spine. 2024. PMID: 38685527 Free article.
In the present literature review, insights into new therapeutic strategies in OA, for example, liposome-based dexamethasone, microspore-based triamcinolone, nerve growth factor antagonist, anti-ADAMTS-5 (A Disintegrin And Metalloproteinase Thrombospoidin Motifs - 5) …
In the present literature review, insights into new therapeutic strategies in OA, for example, liposome-based dexamethasone, microspore-base …
729 results