Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 2
2000 1
2008 2
2009 1
2010 1
2011 2
2012 2
2013 3
2015 5
2016 4
2017 4
2018 3
2019 1
2020 2
2021 4
2022 6
2023 2
2024 3
2025 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

48 results

Results by year

Filters applied: . Clear all
Page 1
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M. Debras C, et al. PLoS Med. 2022 Mar 24;19(3):e1003950. doi: 10.1371/journal.pmed.1003950. eCollection 2022 Mar. PLoS Med. 2022. PMID: 35324894 Free PMC article.
In particular, aspartame (HR = 1.15 [95% CI 1.03 to 1.28], P = 0.002) and acesulfame-K (HR = 1.13 [95% CI 1.01 to 1.26], P = 0.007) were associated with increased cancer risk. ...CONCLUSIONS: In this large cohort study, artificial sweeteners (especially aspartame an …
In particular, aspartame (HR = 1.15 [95% CI 1.03 to 1.28], P = 0.002) and acesulfame-K (HR = 1.13 [95% CI 1.01 to 1.26], P = 0 …
Effect of Non-Nutritive Sweeteners on the Gut Microbiota.
Conz A, Salmona M, Diomede L. Conz A, et al. Nutrients. 2023 Apr 13;15(8):1869. doi: 10.3390/nu15081869. Nutrients. 2023. PMID: 37111090 Free PMC article. Review.
We summarized the results from pre-clinical and clinical studies published over the last ten years that examined the single effects of the most consumed NNS: aspartame, acesulfame-K, sucralose, and saccharin. Pre-clinical studies have given conflicting results for v …
We summarized the results from pre-clinical and clinical studies published over the last ten years that examined the single effects of the m …
Understanding the link between aspartame and cancer.
Soffritti M. Soffritti M. Expert Rev Anticancer Ther. 2024 Sep;24(9):793-802. doi: 10.1080/14737140.2024.2383675. Epub 2024 Jul 31. Expert Rev Anticancer Ther. 2024. PMID: 39041328 Review.
Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced controversial results. ...Adequate long-term carcinogenicity bioassays on other diffuse artificial sweeteners such as acesulfame-k, …
Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced contro …
Long-term metabolic effects of non-nutritive sweeteners.
Rathaus M, Azem L, Livne R, Ron S, Ron I, Hadar R, Efroni G, Amir A, Braun T, Haberman Y, Tirosh A. Rathaus M, et al. Mol Metab. 2024 Oct;88:101985. doi: 10.1016/j.molmet.2024.101985. Epub 2024 Jul 6. Mol Metab. 2024. PMID: 38977130 Free PMC article.
Non-nutritive sweeteners (NNSs) offer a potential solution to reduce sugar intake, yet their metabolic safety remains debated. This study aimed to systematically assess the long-term metabolic effects of commonly used NNSs under both normal and obesogenic conditions. METHO …
Non-nutritive sweeteners (NNSs) offer a potential solution to reduce sugar intake, yet their metabolic safety remains debated. This s …
Re-evaluation of acesulfame K (E 950) as food additive.
EFSA Panel on Food Additives and Flavourings (FAF); Castle L, Andreassen M, Aquilina G, Bastos ML, Boon P, Fallico B, FitzGerald R, Frutos Fernandez MJ, Grasl-Kraupp B, Gundert-Remy U, Gürtler R, Houdeau E, Kurek M, Louro H, Morales P, Passamonti S, Batke M, Bruzell E, Chipman J, Cheyns K, Crebelli R, Fortes C, Fürst P, Halldorsson T, Leblanc JC, Mirat M, Lindtner O, Mortensen A, Wright M, Barmaz S, Civitella C, Le Gall P, Mazzoli E, Rasinger JD, Rincon A, Tard A, Lodi F. EFSA Panel on Food Additives and Flavourings (FAF), et al. EFSA J. 2025 Apr 30;23(4):e9317. doi: 10.2903/j.efsa.2025.9317. eCollection 2025 Apr. EFSA J. 2025. PMID: 40309404 Free PMC article.
The present opinion deals with the re-evaluation of acesulfame K (E 950) as a food additive. Acesulfame K (E 950) is the chemically manufactured compound 6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide potassium salt. ...Based on the available data, no …
The present opinion deals with the re-evaluation of acesulfame K (E 950) as a food additive. Acesulfame K (E 950 …
Artificial sweeteners: safe or unsafe?
Qurrat-ul-Ain, Khan SA. Qurrat-ul-Ain, et al. J Pak Med Assoc. 2015 Feb;65(2):225-7. J Pak Med Assoc. 2015. PMID: 25842566 Review.
Extensive scientific research has demonstrated the safety of the six low-calorie sweeteners currently approved for use in foods in the U.S. and Europe (stevia, acesulfame-K, aspartame, neotame, saccharin and sucralose), if taken in acceptable quantities daily …
Extensive scientific research has demonstrated the safety of the six low-calorie sweeteners currently approved for use in foods in th …
Chronic administration of caffeine alters acesulfame-K intake and features of fungiform taste buds in mice.
Lu J, Mao Y, Qi J, Han J, Qin Y. Lu J, et al. Int J Food Sci Nutr. 2021 Dec;72(8):1046-1056. doi: 10.1080/09637486.2021.1905783. Epub 2021 Apr 4. Int J Food Sci Nutr. 2021. PMID: 33818252
We found that following a 21-day administration of caffeine, mice showed increased behavioural responses to sweet stimuli (acesulfame-K solution). Mirroring this behavioural change, chronic caffeine treatment evidently decreased the maximal cross-sectional area and …
We found that following a 21-day administration of caffeine, mice showed increased behavioural responses to sweet stimuli (acesulfame …
The safety and regulatory process for low calorie sweeteners in the United States.
Roberts A. Roberts A. Physiol Behav. 2016 Oct 1;164(Pt B):439-444. doi: 10.1016/j.physbeh.2016.02.039. Epub 2016 Feb 27. Physiol Behav. 2016. PMID: 26930537 Review.
Products including aspartame and saccharin, have undergone several rounds of risk assessment by the United States Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA), in relation to a number of potential safety concerns, including carcin …
Products including aspartame and saccharin, have undergone several rounds of risk assessment by the United States Food and Drug Administrati …
Low-/No-Calorie Sweeteners: A Review of Global Intakes.
Martyn D, Darch M, Roberts A, Lee HY, Yaqiong Tian T, Kaburagi N, Belmar P. Martyn D, et al. Nutrients. 2018 Mar 15;10(3):357. doi: 10.3390/nu10030357. Nutrients. 2018. PMID: 29543782 Free PMC article. Review.
The current review examined published data on the intake of all major low-/no-calorie sweeteners-aspartame, acesulfame-K, saccharin, sucralose, cyclamate, thaumatin and steviol glycosides-globally over the last decade. ...
The current review examined published data on the intake of all major low-/no-calorie sweeteners-aspartame, acesulfame-K, sacc …
Hepatic P53 upregulation and the genotoxic potential of acesulfame-K treatment in rats with a special emphasis on in vitro lymphocyte and macrophage activity testing.
Mohammed FF, Abdelrazik EG, Anwar A, Abdelgayed SS. Mohammed FF, et al. Hum Exp Toxicol. 2024 Jan-Dec;43:9603271241236900. doi: 10.1177/09603271241236900. Hum Exp Toxicol. 2024. PMID: 38418425 Free article.
Acesulfame-k (Ace-k) is a widely used artificial sweetener in various products, and long-term cumulative and multisource exposure is possible despite inadequate toxicological data confirming its safety. ...
Acesulfame-k (Ace-k) is a widely used artificial sweetener in various products, and long-term cumulative and multisource expos …
48 results