Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid.
Zhang S, Peng L, Goswami S, Li Y, Dang H, Xing S, Feng P, Nigro G, Liu Y, Ma Y, Liu T, Yang J, Jiang T, Yang Y, Barker N, Sansonetti P, Kundu P.
Zhang S, et al.
Nat Microbiol. 2025 Mar;10(3):765-783. doi: 10.1038/s41564-025-01937-5. Epub 2025 Feb 19.
Nat Microbiol. 2025.
PMID: 39972061
Here we screened crypt-resident bacteria in organoids and found that indole acetic acid (IAA) secreted by Acinetobacter radioresistens inhibits ISC turnover. A. radioresistens inhibited cellular proliferation in tumour slices from CRC patients and inhibited intestin …
Here we screened crypt-resident bacteria in organoids and found that indole acetic acid (IAA) secreted by Acinetobacter radioresis …