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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 2
1959 1
1961 1
1963 3
1964 1
2000 20
2001 84
2002 127
2003 123
2004 126
2005 99
2006 96
2007 92
2008 64
2009 85
2010 80
2011 83
2012 83
2013 85
2014 97
2015 82
2016 73
2017 78
2018 64
2019 28
2020 1
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1,532 results
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Nuclear pore complex tethers to the cytoskeleton
Goldberg MW. Semin Cell Dev Biol 2017 - Review. PMID 28676424
However, the nuclear pore complexes, which mediate the transport of soluble and membrane bound molecules, are also linked to the microtubule network, primarily via motor proteins (dynein and kinesins) which are linked, most importantly, to the cytoplasmic filament protein of the nuclear pore complex, Nup358, by the adaptor BicD2. The evidence for such linkages and possible roles in nuclear migration, cell cycle control, nuclear transport and cell architecture are discussed....
However, the nuclear pore complexes, which mediate the transport of soluble and membrane bound molecules, are also linked to the micr …
Inhibitors of nuclear transport.
Jans DA, et al. Curr Opin Cell Biol 2019 - Review. PMID 30826604
Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated by members of the Importin (IMP) superfamily of transporters of α- and β-types. The first inhibitor of nuclear transport, leptomycin B (LMB), was shown to be a specific inhibitor of the IMPβ homologue Exportin 1 (EXP1) almost 20 years ago, but it has only been in the last five or so years that new inhibitors of nuclear export as well as import have been identified and characterised. ...
Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated by members of the Import …
The nuclear pore complex--structure and function at a glance
Kabachinski G and Schwartz TU. J Cell Sci 2015 - Review. PMID 26046137 Free PMC article.
Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. ...In this Cell Science at a Glance article and the accompanying poster, we discuss how transport between the nucleoplasm and the cytoplasm is regulated, what we currently know about the structure of individual nucleoporins and the assembled NPC, and how the cell regulates assembly and disassembly of such a massive structure. ...
Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide acces …
ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity
Arii J, et al. Nat Commun 2018. PMID 30139939 Free PMC article.
Vesicle-mediated nucleocytoplasmic transport is a nuclear pore-independent mechanism for the nuclear export of macromolecular complexes, but the molecular basis for this transport remains largely unknown. Here we show that endosomal sorting complex required for transport-III (ESCRT-III) is recruited to the inner nuclear membrane (INM) during the nuclear export of herpes simplex virus 1 (HSV-1). ...
Vesicle-mediated nucleocytoplasmic transport is a nuclear pore-independent mechanism for the nuclear export of macromolecular complex …
The Rules and Functions of Nucleocytoplasmic Shuttling Proteins
Fu X, et al. Int J Mol Sci 2018 - Review. PMID 29757215 Free PMC article.
The former occurs in the cell nucleus, while the latter in the cytoplasm. The separation requires protein to transport across the nuclear envelope to realize a variety of biological functions. Nucleocytoplasmic transport of protein including import to the nucleus and export to the cytoplasm is a complicated process that requires involvement and interaction of many proteins. ...
The former occurs in the cell nucleus, while the latter in the cytoplasm. The separation requires protein to transport
Forcing Entry into the Nucleus.
Lomakin A, et al. Dev Cell 2017 - Review. PMID 29207257 Free article.
Nuclear pore complexes tightly regulate nucleo-cytoplasmic transport, controlling the nuclear concentration of several transcription factors. In a recent issue of Cell, Elosegui-Artola et al. (2017) show that nuclear deformation modulates the nuclear entry rates of YAP/TAZ via nuclear pore stretching, clarifying how forces affect gene transcription....
Nuclear pore complexes tightly regulate nucleo-cytoplasmic transport, controlling the nuclear concentration of several transcription …
Efficient active transport of gene nanocarriers to the cell nucleus.
Suh J, et al. Proc Natl Acad Sci U S A 2003. PMID 12644705 Free PMC article.
We used live-cell real-time multiple particle tracking to quantify the intracellular transport of hundreds of individual nonviral DNA nanocarriers with 5-nm and 33-ms resolution. ...Active gene carrier transport led to efficient perinuclear accumulation within minutes. The results provide direct evidence to dispute the common belief that the efficiency of nonviral gene carriers is dramatically reduced because of the need for their relatively slow random diffusion through the cell cytoplasm to the nucleus and, instead, focuses the attention of rational carrier design on overcoming barriers downstream of perinuclear accumulation....
We used live-cell real-time multiple particle tracking to quantify the intracellular transport of hundreds of individual nonvi …
Surface Properties Determining Passage Rates of Proteins through Nuclear Pores
Frey S, et al. Cell 2018. PMID 29958108 Free article.
Nuclear pore complexes (NPCs) conduct nucleocytoplasmic transport through an FG domain-controlled barrier. We now explore how surface-features of a mobile species determine its NPC passage rate. ...Finally, we document that even for NTR-mediated transport, the surface-properties of the "passively carried" cargo can strikingly affect the translocation rate....
Nuclear pore complexes (NPCs) conduct nucleocytoplasmic transport through an FG domain-controlled barrier. We now explore how surface …
The nuclear export of circular RNAs is primarily defined by their length
Li Z, et al. RNA Biol 2019 - Review. PMID 30526278 Free PMC article.
Most mature circRNAs accumulate in the cytoplasm; however, little is known about how circRNAs are exported from the nucleus to the cytoplasm as they lack many of the common signals used for mRNA export. ...
Most mature circRNAs accumulate in the cytoplasm; however, little is known about how circRNAs are exported from the nucleus to the cy …
Nup62-mediated nuclear import of p63 in squamous cell carcinoma.
Borlido J and D'Angelo MA. EMBO Rep 2018. PMID 29254932 Free PMC article.
Nuclear pore complexes (NPCs) are multiprotein channels that bridge the nucleus with the cytoplasm and regulate all nucleo‐cytoplasmic traffic. ...A new report by Hazawa et al 1 now identifies the central transport channel nucleoporin Nup62 as a novel regulator of cell proliferation and differentiation in squamous cell carcinoma (SCC), via modulation of p63 nucleo‐cytoplasmic transport. ...
Nuclear pore complexes (NPCs) are multiprotein channels that bridge the nucleus with the cytoplasm and regulate all nucleo‐cytoplasmi …
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