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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 4
1966 15
1967 13
1968 17
1969 25
1970 35
1971 42
1972 37
1973 43
1974 54
1975 49
1976 58
1977 42
1978 48
1979 47
1980 66
1981 39
1982 47
1983 65
1984 57
1985 76
1986 79
1987 75
1988 80
1989 79
1990 63
1991 74
1992 69
1993 59
1994 95
1995 80
1996 82
1997 86
1998 93
1999 59
2000 78
2001 61
2002 87
2003 80
2004 99
2005 109
2006 92
2007 102
2008 137
2009 140
2010 183
2011 209
2012 240
2013 266
2014 324
2015 279
2016 285
2017 321
2018 333
2019 140
2020 1
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5,100 results
Results by year
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Page 1
Sepsis-induced acute kidney injury.
Gómez H and Kellum JA. Curr Opin Crit Care 2016 - Review. PMID 27661757 Free PMC article.
For example, acute kidney injury (AKI) occurs in 40-50% of septic patients and increases mortality six to eight-fold. However, the mechanisms by which sepsis causes organ dysfunction are not well understood and hence current therapy remains reactive and nonspecific. RECENT FINDINGS: Recent studies have challenged the previous notion that organ dysfunction is solely secondary to hypoperfusion, by showing, for example, that AKI occurs in the setting of normal or increased renal blood flow; and that it is characterized not by acute tubular necrosis or apoptosis, but rather by heterogeneous areas of colocalized sluggish peritubular blood flow and tubular epithelial cell oxidative stress. ...
For example, acute kidney injury (AKI) occurs in 40-50% of septic patients and increases mortality six to eight-fold. However, …
Biomarkers of renal recovery after acute kidney injury.
Gaião SM and Paiva JAOC. Rev Bras Ter Intensiva 2017 - Review. PMID 29044306 Portuguese, English. Free PMC article.
PubMed, Web of Science and Google Scholar were searched for studies that reported on the epidemiology of renal recovery after acute kidney injury, the risk factors of recovery versus non-recovery after acute kidney injury, and potential biomarkers of acute kidney injury recovery. ...Acute kidney injury recovery requires more study, and its definition needs to be standardized to allow for better and more powerful research on biomarkers because some of them show potential for the prediction of acute kidney injury recovery....
PubMed, Web of Science and Google Scholar were searched for studies that reported on the epidemiology of renal recovery after acute
Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment.
Wang Y and Bellomo R. Nat Rev Nephrol 2017 - Review. PMID 28869251
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the most common clinically important complication in adult patients undergoing open heart surgery, and is associated with increased mortality and morbidity. ...Finally, we explore issues in the use of renal replacement therapy, its timing, its intensity and its preferred modalities in patients with CSA-AKI, and we discuss the prognosis of CSA-AKI in terms of patient survival and kidney recovery....
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the most common clinically important complication in adult patient …
Paradigms of acute kidney injury in the intensive care setting.
Kellum JA and Prowle JR. Nat Rev Nephrol 2018 - Review. PMID 29355173
Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies, variable pathogenesis and diverse outcomes. ...
Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies, variable pathogenesis and divers
The definition of acute kidney injury and its use in practice.
Thomas ME, et al. Kidney Int 2015 - Review. PMID 25317932 Free article.
Acute kidney injury (AKI) is a common syndrome that is independently associated with increased mortality. A standardized definition is important to facilitate clinical care and research. The definition of AKI has evolved rapidly since 2004, with the introduction of the Risk, Injury, Failure, Loss, and End-stage renal disease (RIFLE), AKI Network (AKIN), and Kidney Disease Improving Global Outcomes (KDIGO) classifications. ...
Acute kidney injury (AKI) is a common syndrome that is independently associated with increased mortality. A standardized defin
Immunopathogenesis of Acute Kidney Injury.
Radi ZA. Toxicol Pathol 2018 - Review. PMID 30282524
Pathophysiologically, the classification of acute kidney injury (AKI) can be divided into three categories: (1) prerenal, (2) intrinsic, and (3) postrenal. ...However, other immune cells and pathways such as M2 macrophages, regulatory T cells, progranulin, and autophagy exhibit anti-inflammatory properties and facilitate kidney tissue repair after AKI. ...
Pathophysiologically, the classification of acute kidney injury (AKI) can be divided into three categories: (1) prerenal, (2) …
Pathophysiology of ischemic acute kidney injury.
Sharfuddin AA and Molitoris BA. Nat Rev Nephrol 2011 - Review. PMID 21364518
Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD), and transition from pre-existing CKD to end-stage renal disease. ...We also discuss how therapy targeting specific cell types can minimize the initial and subsequent injury following ischemia, thereby limiting the extent of acute changes and, hopefully, long-term structural and functional alterations to the kidney....
Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading to unacceptably high morbidity and m
[Acute kidney injury: update 2016].
Bienholz A, et al. Dtsch Med Wochenschr 2016. PMID 27031202 German.
Acute kidney injury is still defined by the functional parameters diuresis and serum creatinine. New biomarkers can be sensible additions for the detection of pathogenesis and prognosis. Risk stratification is also very useful for identification of patients at risk for the development of acute kidney injury. This is of increased importance as usual therapeutic treatments are rare and long-term effects are devastating....
Acute kidney injury is still defined by the functional parameters diuresis and serum creatinine. New biomarkers can be sensibl
How Acute Kidney Injury Contributes to Renal Fibrosis.
Yang L. Adv Exp Med Biol 2019 - Review. PMID 31399964
Acute kidney injury (AKI) is a widespread clinical syndrome directly associated with patient short-term and long-term morbidity and mortality. ...Research and clinical trial are underway for emerging biomarkers detecting early kidney injury, predicting kidney disease progression and developing strategies to efficiently treat AKI and to minimize AKI progression to CKD and ESRD. ...
Acute kidney injury (AKI) is a widespread clinical syndrome directly associated with patient short-term and long-term morbidit
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