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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 7
1997 31
1998 17
1999 47
2000 52
2001 74
2002 102
2003 92
2004 437
2005 1594
2006 3560
2007 4276
2008 4715
2009 5247
2010 5605
2011 6399
2012 6730
2013 7229
2014 7014
2015 6983
2016 7165
2017 7315
2018 6901
2019 2948
2020 47
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73,777 results
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Page 1
CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs
Zapata JM, et al. Front Immunol 2018 - Review. PMID 30524423 Free PMC article.
Hence, akin to other members of the TNFR family, it relies on the TNFR-Associated-Factor (TRAF) family of adaptor proteins to build the CD137 signalosome for transducing signals into the cell. ...In addition, available studies have identified a large number of proteins that are recruited to CD137:TRAF complexes including ubiquitin ligases and proteases, kinases, and modulatory proteins. ...
Hence, akin to other members of the TNFR family, it relies on the TNFR-Associated-Factor (TRAF) family of adaptor proteins to …
The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling
Peterson YK and Luttrell LM. Pharmacol Rev 2017 - Review. PMID 28626043 Free PMC article.
The visual/β-arrestins, a small family of proteins originally described for their role in the desensitization and intracellular trafficking of G protein-coupled receptors (GPCRs), have emerged as key regulators of multiple signaling pathways. ...
The visual/β-arrestins, a small family of proteins originally described for their role in the desensitization and intracellular traff …
Necroptosis in health and diseases
Zhou W and Yuan J. Semin Cell Dev Biol 2014 - Review. PMID 25087983 Free article.
Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways
Shi JH and Sun SC. Front Immunol 2018 - Review. PMID 30140268 Free PMC article.
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR superfamily and various other immune receptors. ...This review will focus on the role of TRAF proteins in the regulation of NF-κB and MAPK signaling pathways....
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signal …
Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome
David L, et al. Proc Natl Acad Sci U S A 2018. PMID 29382759 Free PMC article.
Collectively, these data reveal biophysical mechanisms in the assembly of the CARMA1-BCL10-MALT1-TRAF6 complex for signal transduction....
Collectively, these data reveal biophysical mechanisms in the assembly of the CARMA1-BCL10-MALT1-TRAF6 complex for signal transductio …
The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions
Pennington KL, et al. Oncogene 2018 - Review. PMID 29915393 Free PMC article.
14-3-3 proteins are a family of structurally similar phospho-binding proteins that regulate essentially every major cellular function. ...In particular, these interactions place 14-3-3 at the center of the signaling hub that governs critical processes in cancer, including apoptosis, cell cycle progression, autophagy, glucose metabolism, and cell motility. ...
14-3-3 proteins are a family of structurally similar phospho-binding proteins that regulate essentially every major cellular f …
Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
Wingelhofer B, et al. Leukemia 2018 - Review. PMID 29728695 Free PMC article.
STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK-STAT pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and survival in conjunction with other core cancer pathways. ...The JAK-STAT pathway can rapidly reshape the chromatin landscape upon cytokine, hormone, or growth factor stimulation and unphosphorylated STAT proteins also appear to be functional with respect to regulating chromatin accessibility. ...
STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK-STAT pathway. Deregulated STAT3 and STAT5 signaling promotes c …
Apaf-1: Regulation and function in cell death
Shakeri R, et al. Biochimie 2017 - Review. PMID 28192157
Various cellular proteins and small molecules can modulate apoptosome formation and function directly or indirectly. Despite recent progress in understanding the mitochondrial pathway of apoptosis, numerous questions such as the molecular mechanism of Apaf-1 oligomerization and caspase-9 activation remain poorly understood. ...
Various cellular proteins and small molecules can modulate apoptosome formation and function directly or indirectly. Despite recent p …
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