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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1992 3
1993 29
1994 99
1995 120
1996 118
1997 134
1998 157
1999 134
2000 186
2001 189
2002 210
2003 204
2004 209
2005 245
2006 287
2007 353
2008 370
2009 426
2010 424
2011 460
2012 500
2013 501
2014 464
2015 434
2016 483
2017 463
2018 446
2019 226
2020 3
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6,968 results
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Page 1
Effects of Genistein on Differentiation and Viability of Human Visceral Adipocytes.
Grossini E, et al. Nutrients 2018. PMID 30060502 Free PMC article.
Specific kits were used to examine the effects of genistein vs adiponectin on human visceral pre-adipocytes differentiation, cell viability, mitochondrial membrane potential, and oxidative stress in pre-adipocytes and in white/brown adipocytes. ...Similar effects were observed in brown adipocytes and in white adipocytes, although in white cells the increase of cell viability was inversely related to the dose. ...
Specific kits were used to examine the effects of genistein vs adiponectin on human visceral pre-adipocytes differentiation, cell via …
Effects of Epigallocatechin-3-Gallate on Autophagic Lipolysis in Adipocytes.
Kim SN, et al. Nutrients 2017. PMID 28665330 Free PMC article.
Here, we investigated effects of the major green tea phytochemical, epigallocatechin-3-gallate (EGCG) on triglyceride contents, lipolysis, mitochondrial function, and autophagy, in adipocytes differentiated from C₃H(10)T1/2 cells and immortalized pre-adipocytes in vitro. EGCG reduced the triglycerol content significantly in adipocytes by 25%, comparable to the nutrient starvation state. EGCG did not affect protein kinase A signaling or brown adipocyte marker expression in adipocytes; however, EGCG increased autophagy, as measured by autophagy flux analysis and immunoblot analysis of LC3B, ATG7, and Beclin1. ...
Here, we investigated effects of the major green tea phytochemical, epigallocatechin-3-gallate (EGCG) on triglyceride contents, lipolysis, m …
Dose- and type-dependent effects of long-chain fatty acids on adipogenesis and lipogenesis of bovine adipocytes.
Yanting C, et al. J Dairy Sci 2018. PMID 29153512 Free article.
Differentiation and lipid metabolism of adipocytes have a great influence on milk performance, health, and feed efficiency of dairy cows. ...When the maturation stage was treated with FA, the number of mature adipocytes was not affected, but the lipid content in adipocytes was affected and ranked oleic > linoleic > myristic > stearic > palmitic. ...
Differentiation and lipid metabolism of adipocytes have a great influence on milk performance, health, and feed efficiency of dairy c …
Trans-Cinnamic Acid Stimulates White Fat Browning and Activates Brown Adipocytes.
Kang NH, et al. Nutrients 2019. PMID 30857158 Free PMC article.
In our study tCA induced brown like-phenotype in 3T3-L1 white adipocytes and activated HIB1B brown adipocytes. tCA increased protein content of brown-fat-specific markers (UCP1, PRDM16, and PGC-1α) and expression levels of beige-fat-specific genes (Cd137, Cidea, Cited1, Tbx1, and Tmen26) in 3T3-L1 white adipocytes, as well as brown-fat-specific genes (Lhx8, Ppargc1, Prdm16, Ucp1, and Zic1) in HIB1B brown adipocytes. Furthermore, tCA reduced expression of key adipogenic transcription factors C/EBPα and PPARγ in white adipocytes, but enhanced their expressions in brown adipocytes. ...
In our study tCA induced brown like-phenotype in 3T3-L1 white adipocytes and activated HIB1B brown adipocytes. tCA increased p …
Activation of estrogen receptor alpha induces beiging of adipocytes.
Santos RS, et al. Mol Metab 2018. PMID 30270132 Free PMC article.
RESULTS: Selective ERα activation by PPT increased markers of beiging in vitro in 3T3-L1 and primary adipocytes, whereas, knockdown of ERα with siRNA reduced the ability of PPT to induce beiging in vitro. ...CONCLUSION: Our results demonstrate for the first time that selective-activation of ERα in adipocytes increases markers of beiging and this is likely through induction of AMPK and ATGL-mediated lipolysis providing FFAs as a fuel to activate UCP-1....
RESULTS: Selective ERα activation by PPT increased markers of beiging in vitro in 3T3-L1 and primary adipocytes, whereas, knockdown o …
Exercise and the Regulation of Adipose Tissue Metabolism
Tsiloulis T and Watt MJ. Prog Mol Biol Transl Sci 2015 - Review. PMID 26477915
Finally, we examine recent literature describing how exercise might influence the conversion of traditional white adipose tissue to high energy-consuming "brown-like" adipocytes and the implications that this has on whole-body energy balance....
Finally, we examine recent literature describing how exercise might influence the conversion of traditional white adipose tissue to high ene …
From white to beige adipocytes: therapeutic potential of dietary molecules against obesity and their molecular mechanisms.
Wang S, et al. Food Funct 2019 - Review. PMID 30735224
In addition to classic brown adipose tissue (BAT), the formation of brown-like adipocytes called beige adipocytes, within white adipose tissue (WAT), has attracted much attention as a therapeutic target due to its inducible features when stimulated, resulting in the dissipation of extra energy as heat. ...Although challenges still remain regarding the origin of the beige adipocytes, the crosstalk with activation of BAT and induction of the beiging of white fat may provide attractive potential strategies for management of obesity....
In addition to classic brown adipose tissue (BAT), the formation of brown-like adipocytes called beige adipocytes, within whit …
Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses.
Dowal L, et al. Mediators Inflamm 2017. PMID 28458470 Free PMC article.
White adipocyte monocultures show increased IL-6 secretion compared to brown adipocytes. White adipocytes cocultured with U937 and THP-1 macrophages induced a greater increase in IL-6 secretion compared to brown adipocytes cocultured with both macrophages. ...The effects of adipocytes on macrophages appear to be independent of stimulation state. Brown adipocytes exhibit an intrinsic ability to dampen inflammatory profile of macrophages, while white adipocytes enhance it. ...
White adipocyte monocultures show increased IL-6 secretion compared to brown adipocytes. White adipocytes cocultured with U937 …
L-rhamnose induces browning in 3T3-L1 white adipocytes and activates HIB1B brown adipocytes.
Choi M, et al. IUBMB Life 2018. PMID 29638041 Free article.
Induction of the brown adipocyte-like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. ...Moreover, L-rhamnose markedly elevated expression levels of proteins involved in thermogenesis both in 3T3-L1 white and HIB1B brown adipocytes. ...
Induction of the brown adipocyte-like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due …
Multiplatform Metabolomics Investigation of Antiadipogenic Effects on 3T3-L1 Adipocytes by a Potent Diarylheptanoid.
Du D, et al. J Proteome Res 2018. PMID 29688022 Free PMC article.
In addition, carbohydrate metabolism in diarylheptanoid-1-treated adipocytes further demonstrated the delayed differentiation process by flux analysis. Our results provide valuable information for further understanding the metabolic adjustment in adipocytes subjected to diarylheptanoid 1 treatment. ...
In addition, carbohydrate metabolism in diarylheptanoid-1-treated adipocytes further demonstrated the delayed differentiation process …
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