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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1970 1
1971 6
1972 9
1973 1
1974 9
1975 3
1976 6
1977 4
1978 5
1979 14
1980 9
1981 9
1982 5
1983 19
1984 19
1985 17
1986 14
1987 14
1988 20
1989 20
1990 16
1991 19
1992 12
1993 16
1994 12
1995 23
1996 15
1997 24
1998 21
1999 27
2000 27
2001 30
2002 45
2003 57
2004 58
2005 60
2006 96
2007 130
2008 124
2009 165
2010 174
2011 174
2012 173
2013 237
2014 188
2015 199
2016 229
2017 267
2018 273
2019 109
2020 2
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2,834 results
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Page 1
The role of adipose tissue in cardiovascular health and disease.
Oikonomou EK and Antoniades C. Nat Rev Cardiol 2019 - Review. PMID 30287946
Moreover, the interplay between the adipose tissue and the cardiovascular system is bidirectional, with vascular-derived and heart-derived signals directly affecting adipose tissue biology. ...In addition, we highlight the latest developments in adipose tissue imaging for cardiovascular risk stratification and discuss how therapeutic targeting of the adipose tissue can improve prevention and treatment of cardiovascular disease....
Moreover, the interplay between the adipose tissue and the cardiovascular system is bidirectional, with vascular-derived and h …
Perivascular adipose tissue inflammation in vascular disease.
Nosalski R and Guzik TJ. Br J Pharmacol 2017 - Review. PMID 28063251 Free PMC article.
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular characteristics. ...Inflammatory changes in PVAT's molecular and cellular responses are uniquely different from classical visceral or subcutaneous adipose tissue or from adventitia, emphasizing the unique structural and functional features of this adipose tissue compartment. ...
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologie …
Pathophysiology of type 2 diabetes
Scheen AJ. Acta Clin Belg 2003 - Review. PMID 15068125 Free article.
The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. ...Therefore, the adipose tissue should play a crucial role in the pathogenesis of type 2 diabetes. Although the predominant paradigm used to explain this link is the portal/visceral hypothesis giving a key role in elevated non-esterified fatty acid concentrations, two new emerging paradigms are the ectopic fat storage syndrome (deposition of triglycerides in muscle, liver and pancreatic cells) and the adipose tissue as endocrine organ hypothesis (secretion of various adipocytokins, i.e. leptin, TNF-alpha, resistin, adiponectin, implicated in insulin resistance and possibly beta-cell dysfunction). ...
The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and …
The role of adipose tissue in cancer-associated cachexia.
Vaitkus JA and Celi FS. Exp Biol Med (Maywood) 2017 - Review. PMID 27932592 Free PMC article.
The recent demonstration of functional brown adipose tissue in adults, which is highly metabolic, shifted this paradigm. Additionally, recent studies demonstrate the ability of white adipose tissue to be induced toward the brown adipose phenotype - "beige" or "brite" adipose tissue - in a process referred to as "browning." ...This work reviews a component of CAC that lacks prior discussion: adipose tissue contributions. Uniquely, it discusses all three types of adipose tissue, white, beige, and brown, their interactions, and their contributions to the development and progression of CAC. ...
The recent demonstration of functional brown adipose tissue in adults, which is highly metabolic, shifted this paradigm. Addit …
Adipose tissue and the physiologic underpinnings of metabolic disease.
O'Rourke RW. Surg Obes Relat Dis 2018 - Review. PMID 30193906 Free PMC article.
Adipose tissue dysfunction underlies the pathogenesis of metabolic disease. The metrics used to quantify adiposity and its association with metabolic disease, including body mass index, have limitations with important clinical implications. An understanding of the molecular and cellular mechanisms by which adipose tissue regulates systemic metabolism and contributes to metabolic disease will lead to next-generation adipose tissue-based therapy....
Adipose tissue dysfunction underlies the pathogenesis of metabolic disease. The metrics used to quantify adiposity and its ass
Adipose Tissue Dysfunction: Clinical Relevance and Diagnostic Possibilities.
Schrover IM, et al. Horm Metab Res 2016 - Review. PMID 27065460
Although quantity of adipose tissue is an important determinant of adipose tissue dysfunction, it can be diagnosed in both obese and lean individuals. This implies that not only quantity of adipose tissue should be used as a measure for adipose tissue dysfunction. Instead, focus should be on measuring quality of adipose tissue, which can be done with diagnostic modalities ranging from anthropometric measurements to tissue biopsies and advanced imaging techniques. ...
Although quantity of adipose tissue is an important determinant of adipose tissue dysfunction, it can be diagnos …
Role of adipose tissue in the pathogenesis of cardiac arrhythmias.
Samanta R, et al. Heart Rhythm 2016 - Review. PMID 26277495
However, excess epicardial adipose tissue has been shown to be associated with prevalence and severity of atrial fibrillation. ...These observations suggest a role of adipose tissue in the pathogenesis of cardiac arrhythmias. In this article, we review the role of cardiac adipose tissue in various cardiac arrhythmias and discuss the possible pathophysiologic mechanisms....
However, excess epicardial adipose tissue has been shown to be associated with prevalence and severity of atrial fibrillation. …
Berberine activates thermogenesis in white and brown adipose tissue.
Zhang Z, et al. Nat Commun 2014. PMID 25423280
Promoting brown adipose tissue formation and function increases energy expenditure and hence may counteract obesity. Berberine (BBR) is a compound derived from the Chinese medicinal plant Coptis chinensis. Here we show that BBR increases energy expenditure, limits weight gain, improves cold tolerance and enhances brown adipose tissue (BAT) activity in obese db/db mice. ...
Promoting brown adipose tissue formation and function increases energy expenditure and hence may counteract obesity. Berberine …
Adipose Tissue Oxygenation in Obesity: A Matter of Cardiovascular Risk?
Landini L, et al. Curr Pharm Des 2016 - Review. PMID 26556270
This has led to a renewed interest in the adipose tissue function, historically considered as a passive fat storage. It is now well established that adipose tissue is an organ with an active role in production and release of a variety of molecules called adipocytokines. ...Hypoxia, that occurs when adipocytes expand in obesity, has been proposed as a possible cause of adipose tissue inflammation. ...
This has led to a renewed interest in the adipose tissue function, historically considered as a passive fat storage. It is now …
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