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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 35
1972 313
1973 337
1974 245
1975 320
1976 520
1977 1007
1978 567
1979 681
1980 427
1981 347
1982 718
1983 343
1984 911
1985 505
1986 945
1987 828
1988 983
1989 807
1990 824
1991 1326
1992 631
1993 1001
1994 964
1995 1252
1996 969
1997 1417
1998 1153
1999 909
2000 577
2001 707
2002 569
2003 1209
2004 359
2005 248
2006 657
2007 423
2008 625
2009 712
2010 948
2011 554
2012 1045
2013 759
2014 706
2015 790
2016 1356
2017 1434
2018 1260
2019 1351
2020 324
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37,898 results
Results by year
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Page 1
Brain Tumors of Glial Origin
Waker CA and Lober RM. Adv Exp Med Biol 2019 - Review. PMID 31760651
Isocitrate dehydrogenase (IDH) mutation is an early event in the formation of some diffuse gliomas, and is the best understood mechanism of their epigenetic dysregulation. ...Several molecular subtypes of glioblastoma arise from a common proneural precursor with a tendency toward transition to a mesenchymal subtype. ...
Isocitrate dehydrogenase (IDH) mutation is an early event in the formation of some diffuse gliomas, and is the best understood mechanism
Introduction
Fang Y and Mao R. Adv Exp Med Biol 2019. PMID 31784955
Depressive disorder is one of the most widespread forms of mental disorders which lead to a significant public health concern, such as disability, suicide, and so on. ...For now, anti-depressants used in clinical practice is almost monoamine-based drugs while much more progress have been made in developing new antidepressant medications, like prototypical N-methyl-D-aspartate (NMDA) receptor antagonists, opioid agonists, gamma-aminobutyric acid (GABA(A)) receptors, and psychedelics. ...
Depressive disorder is one of the most widespread forms of mental disorders which lead to a significant public health concern, such a …
Chaperone-Mediated Autophagy.
Yang Q, et al. Adv Exp Med Biol 2019 - Review. PMID 31776997
Chaperone-mediated autophagy (CMA) was the first lysosomal process to be discovered by which intracellular components are selectively degraded. ...Combining results from the current research, we summarize the basic processes, regulatory mechanisms, and physiological functions of CMA and discuss its critical role in the development of diseases....
Chaperone-mediated autophagy (CMA) was the first lysosomal process to be discovered by which intracellular components are selectively …
Inflammation, Frailty and Cardiovascular Disease
Soysal P, et al. Adv Exp Med Biol 2020 - Review. PMID 31894547
Low grade chronic inflammation can also increase the risk of atherosclerosis and insulin resistance which are the leading mechanisms in the development of cardiovascular diseases (CVD). ...
Low grade chronic inflammation can also increase the risk of atherosclerosis and insulin resistance which are the leading mechanisms
AMPK and Autophagy
Li Y and Chen Y. Adv Exp Med Biol 2019 - Review. PMID 31776981
Activated AMPK regulates a variety of metabolic processes, including autophagy. AMPK promotes autophagy directly by phosphorylating autophagy-related proteins in the mTORC1, ULK1, and PIK3C3/VPS34 complexes or indirectly by regulating the expression of autophagy-related genes downstream of transcription factors such as FOXO3, TFEB, and BRD4. ...
Activated AMPK regulates a variety of metabolic processes, including autophagy. AMPK promotes autophagy directly by phosphorylating a …
Multiple Sclerosis
Yamasaki R and Kira JI. Adv Exp Med Biol 2019 - Review. PMID 31760647
While the immunological mechanisms remain to be fully elucidated, invasion of autoreactive T cells into the central nervous system (CNS) tissue is considered the first step of the disease. ...However, there are still few effective treatments for the chronic progressive phase, and it is thus imperative to decipher the mechanism for chronic progression....
While the immunological mechanisms remain to be fully elucidated, invasion of autoreactive T cells into the central nervous system (C …
Autophagy and Ubiquitin-Proteasome System
Wang Y and Le WD. Adv Exp Med Biol 2019 - Review. PMID 31777002
There are two main mechanisms of intracellular protein degradation: the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP). There is a certain relationship between these two mechanisms, and there are some molecules that initiate compensatory effects to prevent disease progression....
There are two main mechanisms of intracellular protein degradation: the ubiquitin-proteasome system (UPS) and the autophagy-lysosome …
Dysflective Cones
Duncan JL and Roorda A. Adv Exp Med Biol 2019 - Review. PMID 31884601
Images of retinal structure are best interpreted in the context of visual function, but clinical measures of visual function lack resolution on the scale of individual cells. Combined with cross-sectional measures of retinal structure acquired with optical coherence tomography (OCT), macular photoreceptor function can be evaluated using visual acuity and fundus-guided microperimetry, but the resolution of these measures is limited to relatively large retinal areas. ...
Images of retinal structure are best interpreted in the context of visual function, but clinical measures of visual function lack res …
Stem Cells in Psychiatry
Kucharska-Mazur J, et al. Adv Exp Med Biol 2019 - Review. PMID 31898786
The development of regenerative medicine has provided new perspectives in many scientific fields, including psychiatry. Stem cell research is getting us closer to discovering the biological foundation of mental disorders. ...The authors also include the implementation of current research regarding neurogenesis in adult brain and induced pluripotent stem cells in investigating concerns in etiopathogenesis of mental disorders as well as the implication of research for treatment of these disorders....
The development of regenerative medicine has provided new perspectives in many scientific fields, including psychiatry. Stem cell res …
37,898 results
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