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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 4
1946 65
1947 64
1948 37
1949 31
1950 48
1951 73
1952 98
1953 195
1954 263
1955 332
1956 380
1957 358
1958 379
1959 396
1960 394
1961 477
1962 553
1963 809
1964 1401
1965 977
1966 683
1967 566
1968 610
1969 543
1970 503
1971 574
1972 521
1973 604
1974 701
1975 836
1976 753
1977 819
1978 1057
1979 963
1980 1281
1981 1422
1982 1578
1983 1379
1984 1516
1985 1429
1986 1678
1987 2141
1988 2404
1989 2725
1990 2627
1991 2498
1992 2852
1993 2866
1994 2752
1995 2889
1996 2831
1997 3224
1998 3046
1999 2982
2000 3114
2001 3160
2002 3538
2003 3546
2004 3701
2005 4282
2006 4500
2007 4711
2008 4890
2009 5379
2010 5765
2011 6047
2012 6454
2013 6904
2014 7071
2015 7169
2016 7357
2017 6863
2018 5959
2019 2421
2020 26
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Search Results

152,634 results
Results by year
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Page 1
The hallmarks of aging.
López-Otín C, et al. Cell 2013 - Review. PMID 23746838 Free PMC article.
Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. ...
Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging
A synopsis on aging-Theories, mechanisms and future prospects.
da Costa JP, et al. Ageing Res Rev 2016 - Review. PMID 27353257 Free PMC article.
There are countless theories as to why and how we age, but, until recently, the very definition of aging - senescence - was still uncertain. ...We therefore explore some of the most relevant changes that take place during aging and, finally, we overview the current status of emergent aging therapies and what the future holds for this field of research. ...
There are countless theories as to why and how we age, but, until recently, the very definition of aging - senescence - was still unc …
Metformin as a Tool to Target Aging.
Barzilai N, et al. Cell Metab 2016 - Review. PMID 27304507 Free PMC article.
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs....
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous mo
Biomarkers of Aging: From Function to Molecular Biology.
Wagner KH, et al. Nutrients 2016 - Review. PMID 27271660 Free PMC article.
Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. ...Thus, there has been no identification of a single biomarker or gold standard tool that can monitor successful or healthy aging. ...
Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a conside
Human aging: usual and successful.
Rowe JW and Kahn RL. Science 1987 - Review. PMID 3299702
Within the category of normal aging, a distinction can be made between usual aging, in which extrinsic factors heighten the effects of aging alone, and successful aging, in which extrinsic factors play a neutral or positive role. Research on the risks associated with usual aging and strategies to modify them should help elucidate how a transition from usual to successful aging can be facilitated....
Within the category of normal aging, a distinction can be made between usual aging, in which extrinsic factors heighten the ef …
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases.
Davalli P, et al. Oxid Med Cell Longev 2016 - Review. PMID 27247702 Free PMC article.
Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment. ...Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging....
Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been pr …
Aging.
Lord SR, et al. Handb Clin Neurol 2018 - Review. PMID 30482312
Metabolic Control of Longevity
López-Otín C, et al. Cell 2016 - Review. PMID 27518560 Free article.
Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the "westernized" lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. ...
Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence met …
Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.
Admasu TD, et al. Dev Cell 2018. PMID 30269951 Free article.
There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We show that dramatic lifespan extension can be achieved by targeting multiple, evolutionarily conserved aging pathways and mechanisms using drug combinations. ...
There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions agains …
152,634 results
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