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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 4
1946 65
1947 64
1948 37
1949 31
1950 48
1951 73
1952 98
1953 195
1954 263
1955 332
1956 380
1957 358
1958 379
1959 396
1960 394
1961 477
1962 554
1963 810
1964 1414
1965 1263
1966 1193
1967 1333
1968 1111
1969 1083
1970 979
1971 1130
1972 1102
1973 1228
1974 1399
1975 1514
1976 1454
1977 1604
1978 2092
1979 2399
1980 2790
1981 3028
1982 3279
1983 2945
1984 3190
1985 3107
1986 3417
1987 3606
1988 3996
1989 4333
1990 4330
1991 4425
1992 4549
1993 4597
1994 4494
1995 4664
1996 4572
1997 5197
1998 4771
1999 4810
2000 5017
2001 5100
2002 5591
2003 5762
2004 5817
2005 6687
2006 6947
2007 7316
2008 7622
2009 8803
2010 9102
2011 8940
2012 9177
2013 9759
2014 9865
2015 9923
2016 10076
2017 9381
2018 8253
2019 3430
2020 45
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241,146 results
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Page 1
Horizons in the evolution of aging.
Flatt T and Partridge L. BMC Biol 2018 - Review. PMID 30124168 Free PMC article.
By the 1980s the evolution of aging had a secure experimental basis. Since the force of selection declines with age, aging evolves due to mutation accumulation or a benefit to fitness early in life. Here we review major insights and challenges that have emerged over the last 35 years: selection does not always necessarily decline with age; higher extrinsic (i.e., environmentally caused) mortality does not always accelerate aging; conserved pathways control aging rate; senescence patterns are more diverse than previously thought; aging is not universal; trade-offs involving lifespan can be 'broken'; aging might be 'druggable'; and human life expectancy continues to rise but compressing late-life morbidity remains a pressing challenge....
By the 1980s the evolution of aging had a secure experimental basis. Since the force of selection declines with age, aging evo …
Metformin as a Tool to Target Aging.
Barzilai N, et al. Cell Metab 2016 - Review. PMID 27304507 Free PMC article.
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs....
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous mo
Chronobiology of Aging: A Mini-Review.
Cornelissen G and Otsuka K. Gerontology 2017 - Review. PMID 27771728 Free article.
Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian acrophase becomes more labile, tending to occur earlier with advancing age. ...Recent work has been shedding light on underlying pathways involved in the aging process, with the promise of interventions to extend healthy life spans. ...
Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian acrophase
The Essence of Aging.
Vijg J and Kennedy BK. Gerontology 2016 - Review. PMID 26389968 Free PMC article.
The idea that aging is a purposeful, programmed series of events is intuitively appealing based on its many conserved aspects and the demonstrated feasibility of modifying life span by manipulating single genes or pathways. Yet, the case for a nonadaptive basis of aging is strong and now all but generally accepted in the field. Here, we briefly review why the case for programmed aging is weak, with a focus on the lack of possible evolutionary beneficial effects....
The idea that aging is a purposeful, programmed series of events is intuitively appealing based on its many conserved aspects and the …
Experimental Models for Aging and their Potential for Novel Drug Discovery.
Folch J, et al. Curr Neuropharmacol 2018 - Review. PMID 28685671 Free PMC article.
METHODS: Research and online content related to aging, antiaging drugs, experimental aging models is reviewed. Moreover, in this review, the main experimental preclinical models of organisms that have contributed to the research in the pharmacology of lifespan extension and the understanding of the aging process are discussed. ...The National Institute on Aging (NIA) developed the Interventions Testing Program (ITP). At the preclinical level, the ITP uses Heterogeneous mouse model (HET) which is probably the most suitable rodent model to study potential drugs against aging prevention. ...
METHODS: Research and online content related to aging, antiaging drugs, experimental aging models is reviewed. Moreover, in th …
Elixir of Life: Thwarting Aging With Regenerative Reprogramming.
Beyret E, et al. Circ Res 2018 - Review. PMID 29301845 Free PMC article.
Regeneration ability of living beings maintains their biological integrity and thus is the major leverage against aging. However, mammalian regeneration capacity is low and further declines during aging. Therefore, modalities that reinforce regeneration can antagonize aging. Recent advances in the field of regenerative medicine have shown that aging is not an irreversible process. ...
Regeneration ability of living beings maintains their biological integrity and thus is the major leverage against aging. However, mam …
Aging.
Lord SR, et al. Handb Clin Neurol 2018 - Review. PMID 30482312
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases.
Davalli P, et al. Oxid Med Cell Longev 2016 - Review. PMID 27247702 Free PMC article.
Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment. ...Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging....
Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been pr …
Mechanisms of the anorexia of aging-a review.
Wysokiński A, et al. Age (Dordr) 2015 - Review. PMID 26232135 Free PMC article.
Aging-associated changes in the regulation of appetite and the lack of hunger have been termed as the anorexia of aging. The etiology of the anorexia of aging is multi-factorial and includes a combination of physiological changes associated with aging (decline in smell and taste, reduced central and peripheral drive to eat, delayed gastric emptying), pathological conditions (depression, dementia, somatic diseases, medications and iatrogenic interventions, oral-health status), and social factors (poverty, loneliness). ...The anorexia of aging is associated with protein-energy malnutrition, sarcopenia, frailty, functional deterioration, morbidity, and mortality. ...
Aging-associated changes in the regulation of appetite and the lack of hunger have been termed as the anorexia of aging. The e
Geroscience: linking aging to chronic disease.
Kennedy BK, et al. Cell 2014. PMID 25417146 Free PMC article.
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan....
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically …
241,146 results
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