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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 8
1967 15
1968 6
1969 9
1970 15
1971 11
1972 14
1973 24
1974 19
1975 26
1976 9
1977 27
1978 35
1979 36
1980 33
1981 27
1982 42
1983 41
1984 85
1985 52
1986 63
1987 67
1988 73
1989 83
1990 105
1991 88
1992 91
1993 83
1994 78
1995 87
1996 101
1997 110
1998 84
1999 87
2000 117
2001 147
2002 195
2003 187
2004 203
2005 274
2006 292
2007 267
2008 357
2009 402
2010 503
2011 514
2012 478
2013 494
2014 446
2015 442
2016 500
2017 482
2018 431
2019 189
2020 2
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7,768 results
Results by year
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Page 1
Experimental Models for Aging and their Potential for Novel Drug Discovery.
Folch J, et al. Curr Neuropharmacol 2018 - Review. PMID 28685671 Free PMC article.
In order to pursue this goal, it is necessary to gather the specific knowledge about the adequate preclinical models that are available to evaluate the beneficial effects of new potential drugs. ...CONCLUSION: Advances in molecular biology have uncovered the potential molecular pathways involved in the aging process. Due to their characteristics, invertebrate models are mainly used for drug screening. ...
In order to pursue this goal, it is necessary to gather the specific knowledge about the adequate preclinical models that are available to e …
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs.
McCubrey JA, et al. Aging (Albany NY) 2017 - Review. PMID 28611316 Free PMC article.
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. ...CUR and modified derivatives have been shown to have potent anti-cancer effects, especially on cancer stem cells (CSC). BBR is also isolated from various plants (e.g., Coptis chinensis) and has been used for centuries in traditional medicine to treat diseases such as adult- onset diabetes. ...
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key …
Metformin as a Tool to Target Aging.
Barzilai N, et al. Cell Metab 2016 - Review. PMID 27304507 Free PMC article.
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs....
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous mo
The Clinical Potential of Senolytic Drugs
Kirkland JL, et al. J Am Geriatr Soc 2017. PMID 28869295 Free PMC article.
To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, because use of long-term endpoints such as lifespan or healthspan is not feasible. These strategies include testing effects on multimorbidity, accelerated aging-like conditions, diseases with localized accumulation of senescent cells, potentially fatal diseases associated with senescent cell accumulation, age-related loss of physiological resilience, and frailty. ...
To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being dev …
Paradoxes of senolytics
Blagosklonny MV. Aging (Albany NY) 2018. PMID 30594910 Free PMC article.
Effect of antioxidants supplementation on aging and longevity.
Sadowska-Bartosz I and Bartosz G. Biomed Res Int 2014 - Review. PMID 24783202 Free PMC article.
If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, lifespan of organisms should be extended by administration of exogenous antioxidants. ...Mechanisms of effects of antioxidants, often due to indirect antioxidant action or to action not related to the antioxidant properties of the compounds administered, are discussed. ...
If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, lifespan of or …
Mechanisms involved in anti-aging effects of guarana (Paullinia cupana) in Caenorhabditis elegans.
Arantes LP, et al. Braz J Med Biol Res 2018. PMID 29972429 Free PMC article.
Anti-aging potential of guarana was also demonstrated in Caenorhabditis elegans; however, the mechanisms involved in its effects are not clear. ...Our results contribute to the comprehension of guarana effects in vivo, which might be helpful to prevent or treat aging-associated disorders, and also suggest purinergic signaling as a plausible therapeutic target for longevity studies....
Anti-aging potential of guarana was also demonstrated in Caenorhabditis elegans; however, the mechanisms involved in its effects
Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism
Shintani H, et al. Nutrients 2018 - Review. PMID 30469486 Free PMC article.
Among these, we focus on upstream-type CRMs and propose their classification as compounds with energy metabolism inhibition effects, particularly glucose metabolism modulation effects. The upstream-type CRMs reviewed include chitosan, acarbose, sodium-glucose cotransporter 2 inhibitors, and hexose analogs such as 2-deoxy-d-glucose, d-glucosamine, and d-allulose, which show antiaging and longevity effects. ...
Among these, we focus on upstream-type CRMs and propose their classification as compounds with energy metabolism inhibition effects, …
Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease.
Serino A and Salazar G. Nutrients 2018 - Review. PMID 30597847 Free PMC article.
Aging is a major risk factor in the development of chronic diseases affecting various tissues including the cardiovascular system, muscle and bones. ...We also discuss the therapeutic potential of polyphenols in reducing the effects of the SASP and the incidence of CVD....
Aging is a major risk factor in the development of chronic diseases affecting various tissues including the cardiovascular system, mu
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