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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 2
1960 3
1961 8
1962 7
1967 2
1968 1
1971 1
1973 2
1974 2
1975 2
1976 3
1977 2
1978 6
1979 5
1980 1
1981 1
1982 1
1983 2
1984 2
1985 1
1986 127
1987 500
1988 565
1989 750
1990 704
1991 607
1992 676
1993 723
1994 751
1995 715
1996 644
1997 666
1998 612
1999 586
2000 502
2001 557
2002 608
2003 478
2004 491
2005 568
2006 575
2007 680
2008 653
2009 661
2010 687
2011 699
2012 770
2013 829
2014 857
2015 862
2016 909
2017 898
2018 793
2019 282
2020 3
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Search Results

20,333 results
Results by year
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Page 1
Cellular Metabolism and Aging.
Catic A. Prog Mol Biol Transl Sci 2018 - Review. PMID 29653684 Free PMC article.
Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of relevant pathways can extend life span. In this review, we will outline how cellular biochemistry and energy homeostasis change during aging. We will highlight protein quality control, mitochondria, epigenetics, nutrient-sensing pathways, as well as the interplay between these systems with respect to their impact on cellular health....
Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of relevant pathways can extend life span. In this …
Metabolic Control of Longevity
López-Otín C, et al. Cell 2016 - Review. PMID 27518560 Free article.
Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the "westernized" lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. ...
Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence …
From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.
Wiley CD and Campisi J. Cell Metab 2016 - Review. PMID 27304503 Free PMC article.
However, senescent cells can also drive phenotypes associated with aging. Although the senescence-associated growth arrest prevents the development of cancer, and the metabolism of cancer cells has been studied in depth, the metabolic causes and consequences of cellular senescence were largely unexplored until recently. ...These discoveries have important implications for both cancer and aging. In this review, we highlight some of the recent links between metabolism and phenotypes that are commonly associated with senescent cells....
However, senescent cells can also drive phenotypes associated with aging. Although the senescence-associated growth arrest prevents t …
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea IM, et al. Front Immunol 2018 - Review. PMID 29686666 Free PMC article.
Despite research there is no clear understanding about the causes of "inflamm-aging" that underpin most major age-related diseases, including atherosclerosis, diabetes, Alzheimer's disease, rheumatoid arthritis, cancer, and aging itself. ...Conversely there may be learning from molecular or genetic pathways from long-lived cohorts who exemplify good quality aging. ...
Despite research there is no clear understanding about the causes of "inflamm-aging" that underpin most major age-related diseases, i …
Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases.
Ren J and Zhang Y. Trends Pharmacol Sci 2018 - Review. PMID 30458935 Free PMC article.
In particular, high morbidity and mortality have been associated with cardiovascular aging, but effective clinical therapeutic remedies are suboptimal for the ever-rising aging population. ...Induction of autophagy using rapamycin, resveratrol, nicotinamide derivatives, metformin, urolithin A, or spermidine delays aging, prolongs lifespan, and improves cardiovascular function in aging. ...
In particular, high morbidity and mortality have been associated with cardiovascular aging, but effective clinical therapeutic remedi …
The metabolic regulation of aging.
Finkel T. Nat Med 2015 - Review. PMID 26646498
Here we review the environmental and genetic manipulations that link cellular and organismal metabolism to aging. In particular, we explore how nutrients are sensed and how various intracellular energy nodes seem to coordinate distinct metabolic alterations linked to extended longevity. ...Finally, we review a host of new targeted pharmacological approaches that attempt to exploit the connection between aging and metabolism to treat a wide range of age-related diseases. ...
Here we review the environmental and genetic manipulations that link cellular and organismal metabolism to aging. In particula …
Ageing, metabolism and cardiovascular disease.
Costantino S, et al. J Physiol 2016 - Review. PMID 26391109 Free PMC article.
In the present review, we carefully describe novel molecular cues underpinning ageing, metabolism and CVD. In particular, we describe a dynamic interplay between emerging pathways such as FOXOs, AMPK, SIRT1, p66(Shc) , JunD and NF-kB. ...
In the present review, we carefully describe novel molecular cues underpinning ageing, metabolism and CVD. In particular, we describe …
Caloric restriction and cellular senescence
Fontana L, et al. Mech Ageing Dev 2018 - Review. PMID 30395873
Senescent cells are implicated in a number of biological functions, from embryogenesis to aging. Significantly, excessive accumulation of senescent cells is associated to a decline of regenerative capacity and chronic inflammation. ...Calorie restriction (CR) without malnutrition is currently the most effective non-genetic intervention to delay aging phenotypes. ...
Senescent cells are implicated in a number of biological functions, from embryogenesis to aging. Significantly, excessive accumulatio …
20,333 results
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