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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 13
1954 28
1955 161
1956 94
1957 4
1958 28
1959 75
1960 127
1961 186
1962 142
1964 7
1965 47
1966 177
1967 119
1968 104
1969 6
1971 1
1972 2
1973 3
1974 4
1975 6
1976 5
1977 3
1978 10
1979 8
1980 5
1981 5
1982 3
1983 5
1984 5
1985 18
1986 338
1987 1235
1988 1623
1989 1915
1990 1885
1991 1759
1992 2028
1993 2169
1994 2114
1995 2149
1996 1990
1997 2298
1998 2289
1999 2231
2000 2201
2001 2340
2002 2561
2003 2411
2004 2552
2005 3002
2006 3089
2007 3343
2008 3250
2009 3367
2010 3460
2011 3444
2012 3652
2013 3840
2014 3859
2015 3834
2016 3875
2017 3636
2018 3205
2019 1238
2020 7
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Search Results

81,737 results
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Page 1
A synopsis on aging-Theories, mechanisms and future prospects.
da Costa JP, et al. Ageing Res Rev 2016 - Review. PMID 27353257 Free PMC article.
There are countless theories as to why and how we age, but, until recently, the very definition of aging - senescence - was still uncertain. ...We therefore explore some of the most relevant changes that take place during aging and, finally, we overview the current status of emergent aging therapies and what the future holds for this field of research. ...
There are countless theories as to why and how we age, but, until recently, the very definition of aging - senescence - was still unc …
Horizons in the evolution of aging.
Flatt T and Partridge L. BMC Biol 2018 - Review. PMID 30124168 Free PMC article.
By the 1980s the evolution of aging had a secure experimental basis. Since the force of selection declines with age, aging evolves due to mutation accumulation or a benefit to fitness early in life. Here we review major insights and challenges that have emerged over the last 35 years: selection does not always necessarily decline with age; higher extrinsic (i.e., environmentally caused) mortality does not always accelerate aging; conserved pathways control aging rate; senescence patterns are more diverse than previously thought; aging is not universal; trade-offs involving lifespan can be 'broken'; aging might be 'druggable'; and human life expectancy continues to rise but compressing late-life morbidity remains a pressing challenge....
By the 1980s the evolution of aging had a secure experimental basis. Since the force of selection declines with age, aging evo …
Biology of Healthy Aging and Longevity.
Carmona JJ and Michan S. Rev Invest Clin 2016 - Review. PMID 27028172 Free article.
Aging is a complex multifactorial process of molecular and cellular decline that affects tissue function over time, rendering organisms frail and susceptible to disease and death. ...This review summarizes key molecular mechanisms underlying the biology of healthy aging and longevity....
Aging is a complex multifactorial process of molecular and cellular decline that affects tissue function over time, rendering organis
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases.
Davalli P, et al. Oxid Med Cell Longev 2016 - Review. PMID 27247702 Free PMC article.
Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment. ...Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging....
Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been pr …
Biomarkers of Aging: From Function to Molecular Biology.
Wagner KH, et al. Nutrients 2016 - Review. PMID 27271660 Free PMC article.
Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. ...Thus, there has been no identification of a single biomarker or gold standard tool that can monitor successful or healthy aging. ...
Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a conside
Human aging: usual and successful.
Rowe JW and Kahn RL. Science 1987 - Review. PMID 3299702
Within the category of normal aging, a distinction can be made between usual aging, in which extrinsic factors heighten the effects of aging alone, and successful aging, in which extrinsic factors play a neutral or positive role. Research on the risks associated with usual aging and strategies to modify them should help elucidate how a transition from usual to successful aging can be facilitated....
Within the category of normal aging, a distinction can be made between usual aging, in which extrinsic factors heighten the ef …
Longevity and aging. Mechanisms and perspectives.
Labat-Robert J and Robert L. Pathol Biol (Paris) 2015 - Review. PMID 26416405
Aging is multifactorial, not "coded" in the genome. There are, however, a number of well-studied physical and biological parameters involved in aging, which can be determined and quantitated. We shall try to identify parameters affecting longevity as well as aging and suggest some reasonable predictions for the future....
Aging is multifactorial, not "coded" in the genome. There are, however, a number of well-studied physical and biological parameters i
The Role of Immunosenescence in the Development of Age-Related Diseases
Fülöp T, et al. Rev Invest Clin 2016 - Review. PMID 27103044 Free article.
Aging is a complex phenomenon leading to numerous changes in the physiological systems of the body. One of the most important changes, called immunosenescence, occurs in the immune system. ...Aging, likely via inflammaging, is also associated with the emergence of chronic diseases including cardiovascular and neurodegenerative diseases, cancer, and diabetes mellitus type 2. ...
Aging is a complex phenomenon leading to numerous changes in the physiological systems of the body. One of the most important changes
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