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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 4
1946 30
1947 29
1948 45
1949 46
1950 53
1951 80
1952 90
1953 93
1954 74
1955 90
1956 84
1957 77
1958 71
1959 81
1960 100
1961 126
1962 178
1963 525
1964 735
1965 558
1966 611
1967 852
1968 949
1969 1042
1970 1102
1971 1258
1972 1297
1973 1330
1974 1418
1975 1198
1976 1019
1977 998
1978 811
1979 912
1980 845
1981 755
1982 789
1983 812
1984 842
1985 942
1986 805
1987 783
1988 828
1989 874
1990 936
1991 973
1992 892
1993 919
1994 883
1995 884
1996 866
1997 866
1998 877
1999 818
2000 902
2001 848
2002 897
2003 941
2004 940
2005 997
2006 1054
2007 1054
2008 1103
2009 1104
2010 1274
2011 1363
2012 1459
2013 1426
2014 1347
2015 1229
2016 1158
2017 1087
2018 1000
2019 520
2020 12
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54,303 results
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Page 1
Alkaline Phosphatase Replacement Therapy.
Bianchi ML and Vai S. Adv Exp Med Biol 2019 - Review. PMID 31482501
Hypophosphatasia (HPP) is a rare genetic disease, characterized by the defective production of tissue-non-specific alkaline phosphatase (TNSALP). ...
Hypophosphatasia (HPP) is a rare genetic disease, characterized by the defective production of tissue-non-specific alkaline phosph
Alkaline Phosphatase Replacement Therapy for Hypophosphatasia in Development and Practice.
Bowden SA and Foster BL. Adv Exp Med Biol 2019 - Review. PMID 31482504
Hypophosphatasia (HPP) is an inherited disorder that affects bone and tooth mineralization characterized by low serum alkaline phosphatase. HPP is caused by loss-of-function mutations in the ALPL gene encoding the protein, tissue-nonspecific alkaline phosphatase (TNSALP). ...
Hypophosphatasia (HPP) is an inherited disorder that affects bone and tooth mineralization characterized by low serum alkaline pho
Loss of Intestinal Alkaline Phosphatase Leads to Distinct Chronic Changes in Bone Phenotype.
Kuehn F, et al. J Surg Res 2018. PMID 30463736
Serum levels of alkaline phosphatase, calcium, and phosphorus were measured. Target cell response upon exposure to serum from IAP-KO and WT mice was quantified using primary bone marrow macrophages. ...IAP (alkaline phosphatase 3) expression in bone was vanishingly low compared to the duodenum (bone versus duodenum, 56.9 ± 17.7 versus 25,430.3 ± 10,884.5 relative expression, P = 0.01). ...
Serum levels of alkaline phosphatase, calcium, and phosphorus were measured. Target cell response upon exposure to serum from …
Prognostic value of serum alkaline phosphatase in spinal metastatic disease.
Karhade AV, et al. Br J Cancer 2019 - Clinical Trial. PMID 30792532 Free PMC article.
Bivariate and multivariate analyses were used to determine if serum alkaline phosphatase was an independent prognostic marker for survival. ...On multivariate analysis, elevated serum alkaline phosphatase was identified as an independent prognostic factor for survival in spinal metastatic disease. ...
Bivariate and multivariate analyses were used to determine if serum alkaline phosphatase was an independent prognostic marker …
Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia.
Liu W, et al. Theranostics 2018. PMID 30555565 Free PMC article.
This study aims to reveal a previously unknown role of tissue-nonspecific alkaline phosphatase (TNSALP) in controlling BMMSC lineage selection. Methods: We compared the characteristics of cultured BMMSCs from patients with hypophosphatasia (HPP), which is caused by mutations in the liver/bone/kidney alkaline phosphatase (ALPL) gene, and an ALPL knockout (ko) mouse model. ...
This study aims to reveal a previously unknown role of tissue-nonspecific alkaline phosphatase (TNSALP) in controlling BMMSC l …
Regulation of osteoblasts by alkaline phosphatase in ankylosing spondylitis.
Jo S, et al. Int J Rheum Dis 2019. PMID 30415492
Alkaline phosphatase (ALP) activity is reported to be high in AS, but little is known about the molecular relationship between ALP and AS. ...RESULTS: Alkaline phosphatase level was higher in AS compared with RA and HC and was associated with radiograph progression. ...
Alkaline phosphatase (ALP) activity is reported to be high in AS, but little is known about the molecular relationship between
Alkaline Phosphatase-Triggered Self-Assembly of Near-Infrared Nanoparticles for the Enhanced Photoacoustic Imaging of Tumors.
Wu C, et al. Nano Lett 2018. PMID 30481463
However, to the best of our knowledge, using an alkaline phosphatase (ALP)-activatable probe for the enhanced PA imaging of tumors has not been reported. ...
However, to the best of our knowledge, using an alkaline phosphatase (ALP)-activatable probe for the enhanced PA imaging of tu …
Retrospective evaluation of a local protocol used to enhance laboratory savings through minimizing the performance of alkaline phosphatase isoenzyme analysis.
Haji SM, et al. Ann Clin Biochem 2019. PMID 30450943
BACKGROUND: Alkaline phosphatase isoenzyme analysis is an expensive and time-consuming laboratory test. We evaluated the effect of a locally derived screening algorithm for alkaline phosphatase isoenzyme requests on the number of alkaline phosphatase isoenzyme analyses performed, laboratory cost and patient care. ...RESULTS: Compliance with this algorithm led to the normalization of subsequent serum alkaline phosphatase in 97% of patients without requiring alkaline phosphatase isoenzyme analysis. ...
BACKGROUND: Alkaline phosphatase isoenzyme analysis is an expensive and time-consuming laboratory test. We evaluated the effec …
Nanobody-Alkaline Phosphatase Fusion Protein-Based Enzyme-Linked Immunosorbent Assay for One-Step Detection of Ochratoxin A in Rice.
Sun Z, et al. Sensors (Basel) 2018. PMID 30463338 Free PMC article.
To monitor OTA in rice, a sensitive, selective, and one-step enzyme-linked immunosorbent assay (ELISA) using a nanobody-alkaline phosphatase fusion protein (Nb28-AP) was developed. ...
To monitor OTA in rice, a sensitive, selective, and one-step enzyme-linked immunosorbent assay (ELISA) using a nanobody-alkaline p
Overcoming the Barrier
Geha RM, et al. N Engl J Med 2018. PMID 30575451
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