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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 15
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1487
1843 1118
1844 1248
1845 1278
1846 1404
1847 1367
1848 1204
1849 1208
1850 1126
1851 1228
1852 1309
1853 1559
1854 1306
1855 1587
1856 1587
1857 1488
1858 1541
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1139
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2180
1878 2454
1879 2399
1880 2646
1881 3149
1882 2743
1883 3127
1884 3050
1885 3338
1886 3291
1887 3965
1888 4002
1889 4196
1890 4025
1891 3578
1892 4094
1893 4369
1894 3801
1895 4130
1896 4414
1897 4688
1898 4632
1899 4169
1900 3786
1901 3886
1902 3968
1903 3910
1904 4060
1905 4067
1906 3872
1907 4323
1908 4513
1909 4766
1910 4885
1911 5099
1912 5016
1913 5250
1914 5243
1915 4702
1916 4570
1917 4323
1918 4595
1919 4717
1920 5037
1921 4703
1922 4192
1923 4521
1924 4945
1925 5058
1926 5397
1927 5945
1928 5537
1929 5798
1930 5694
1931 5572
1932 5629
1933 5695
1934 5577
1935 5736
1936 5448
1937 5379
1938 5829
1939 5614
1940 5024
1941 4865
1942 4800
1943 4543
1944 4764
1945 20490
1946 53907
1947 65002
1948 70710
1949 62805
1950 85755
1951 103744
1952 108056
1953 108915
1954 105914
1955 108544
1956 107007
1957 111522
1958 109458
1959 109963
1960 112140
1961 120102
1962 125636
1963 141521
1964 162087
1965 176644
1966 179739
1967 191500
1968 207848
1969 215048
1970 218966
1971 222874
1972 227506
1973 230659
1974 234537
1975 248267
1976 250371
1977 249848
1978 258285
1979 265573
1980 267223
1981 271548
1982 283173
1983 294844
1984 302796
1985 319038
1986 331511
1987 347495
1988 364055
1989 378086
1990 382989
1991 380568
1992 382207
1993 390212
1994 401537
1995 410824
1996 420920
1997 418673
1998 436462
1999 453621
2000 490662
2001 502903
2002 520562
2003 548159
2004 591681
2005 649996
2006 696796
2007 732836
2008 780032
2009 819392
2010 881937
2011 956146
2012 1022246
2013 1073071
2014 1125535
2015 1166332
2016 1198264
2017 1218962
2018 1262579
2019 1318916
2020 1503537
2021 1641969
2022 1637155
2023 1544113
2024 310953

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34,561,427 results

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Quoted phrases not found in phrase index: "Priority Journal", "Neurons Drug Effects Metabolism"
Page 1
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Israel MA, et al. Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821. Nature. 2012. PMID: 22278060 Free PMC article.
Virtually all cells exhibited normal electrophysiological activity. Relative to controls, iPSC-derived, purified neurons from the two APP(Dp) patients and patient sAD2 exhibited significantly higher levels of the pathological markers amyloid-beta(1-40), phospho-tau(Thr 231 …
Virtually all cells exhibited normal electrophysiological activity. Relative to controls, iPSC-derived, purified neurons from the two …
The preparation of primary cortical neuron cultures and a practical application using immunofluorescent cytochemistry.
Sciarretta C, Minichiello L. Sciarretta C, et al. Methods Mol Biol. 2010;633:221-31. doi: 10.1007/978-1-59745-019-5_16. Methods Mol Biol. 2010. PMID: 20204631
Traditionally, cultures of primary cortical neurons are prepared from embryonic animals because at prenatal stages neurons have not yet developed extensive axonal and dendritic arbors and are not highly innervated, thus rendering the cells less susceptible to damage …
Traditionally, cultures of primary cortical neurons are prepared from embryonic animals because at prenatal stages neurons hav …
Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.
Tomita T. Tomita T. Adv Biol Regul. 2017 May;64:33-38. doi: 10.1016/j.jbior.2017.01.001. Epub 2017 Jan 5. Adv Biol Regul. 2017. PMID: 28082052 Review.
Several lines of evidence suggest that accumulation of Abeta by increased production or decreased degradation induces the tau-mediated neuronal toxicity and symptomatic manifestations of AD. Thus, the dynamics of cerebral Abeta, called as "Abeta economy", would be the mech …
Several lines of evidence suggest that accumulation of Abeta by increased production or decreased degradation induces the tau-mediated ne
Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives.
Mattson MP. Mattson MP. Physiol Rev. 1997 Oct;77(4):1081-132. doi: 10.1152/physrev.1997.77.4.1081. Physiol Rev. 1997. PMID: 9354812 Review.
beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a multifunctional protein that is widely expressed in the nervous system. beta-Amyl
beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-peptide (A beta) that accumulat …
Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.
Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M. Tagami S, et al. Cell Rep. 2017 Oct 3;21(1):259-273. doi: 10.1016/j.celrep.2017.09.032. Cell Rep. 2017. PMID: 28978478 Free article.
However, a large phase 3 trial of semagacestat, a potential non-transition state analog (non-TSA) GSI, in patients with Alzheimer's disease (AD) was terminated due to unexpected aggravation of cognitive deficits and side effects. Here, we show that some semagacestat eff
However, a large phase 3 trial of semagacestat, a potential non-transition state analog (non-TSA) GSI, in patients with Alzheimer's disease …
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Bettegazzi B, Sebastian Monasor L, Bellani S, Codazzi F, Restelli LM, Colombo AV, Deigendesch N, Frank S, Saito T, Saido TC, Lammich S, Tahirovic S, Grohovaz F, Zacchetti D. Bettegazzi B, et al. Cell Death Dis. 2021 Aug 4;12(8):769. doi: 10.1038/s41419-021-04062-3. Cell Death Dis. 2021. PMID: 34349120 Free PMC article.
We provide clear evidence for the role of Casein Kinase 2 in the control of activity-driven BACE1 expression in cultured primary neurons, organotypic brain slices, and murine AD models. More specifically, we demonstrate that neuronal activity promotes Casein …
We provide clear evidence for the role of Casein Kinase 2 in the control of activity-driven BACE1 expression in cultured primary n
The Intracellular Domain of Amyloid Precursor Protein is a Potential Therapeutic Target in Alzheimer's Disease.
Nagase H, Nakayama K. Nagase H, et al. Curr Drug Discov Technol. 2014;11(4):243-58. doi: 10.2174/1570163811666141121101358. Curr Drug Discov Technol. 2014. PMID: 25413946 Review.
Thus, it may be necessary to think about this problem from a different viewpoint. gamma-Secretase was initially identified as an enzyme that cleaves amyloid precursor protein (APP) and produces Abeta. Although the primary function of gamma-secretase has not b …
Thus, it may be necessary to think about this problem from a different viewpoint. gamma-Secretase was initially identified as an enzyme that …
Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.
Mukherjee A, Song E, Kihiko-Ehmann M, Goodman JP Jr, Pyrek JS, Estus S, Hersh LB. Mukherjee A, et al. J Neurosci. 2000 Dec 1;20(23):8745-9. doi: 10.1523/JNEUROSCI.20-23-08745.2000. J Neurosci. 2000. PMID: 11102481 Free PMC article.
This was followed by a slower cleavage at the Lys(28)-Gly(29), Val(18)-Phe(19), and Phe(20)-Ala(21) positions. None of the products appeared to be further metabolized by insulysin. Using a rat cortical cell system, the action of insulysin on Abeta(1-40) and A …
This was followed by a slower cleavage at the Lys(28)-Gly(29), Val(18)-Phe(19), and Phe(20)-Ala(21) positions. None of the products appeared …
Pioglitazone prevents tau oligomerization.
Hamano T, Shirafuji N, Makino C, Yen SH, Kanaan NM, Ueno A, Suzuki J, Ikawa M, Matsunaga A, Yamamura O, Kuriyama M, Nakamoto Y. Hamano T, et al. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1035-42. doi: 10.1016/j.bbrc.2016.08.016. Epub 2016 Aug 16. Biochem Biophys Res Commun. 2016. PMID: 27543203
To test whether the PPARgamma agonist pioglitazone (PIO) is also effective in preventing tau aggregation in AD, we used a cellular model in which wild-type tau protein (4R0N) is overexpressed (M1C cells) (Hamano et al., 2012) as well as primary neuronal cultures. PIO reduc …
To test whether the PPARgamma agonist pioglitazone (PIO) is also effective in preventing tau aggregation in AD, we used a cellular model in …
The release and transmission of amyloid precursor protein via exosomes.
Zheng T, Wu X, Wei X, Wang M, Zhang B. Zheng T, et al. Neurochem Int. 2018 Mar;114:18-25. doi: 10.1016/j.neuint.2017.12.009. Epub 2017 Dec 23. Neurochem Int. 2018. PMID: 29277576
Amyloid precursor protein (APP) processing is central in Alzheimer's disease (AD) pathogenesis. ...We have demonstrated that these exosomes contained APP and were capable of efficiently transferring APP to normal primary neurons. Moreover, these exosom
Amyloid precursor protein (APP) processing is central in Alzheimer's disease (AD) pathogenesis. ...We have demonstrated
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