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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 15
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1118
1844 1248
1845 1278
1846 1406
1847 1367
1848 1204
1849 1208
1850 1127
1851 1228
1852 1310
1853 1559
1854 1306
1855 1587
1856 1587
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1139
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2180
1878 2454
1879 2399
1880 2646
1881 3149
1882 2743
1883 3127
1884 3050
1885 3338
1886 3291
1887 3965
1888 4002
1889 4196
1890 4025
1891 3607
1892 4081
1893 4370
1894 3801
1895 4129
1896 4414
1897 4689
1898 4632
1899 4169
1900 3786
1901 3887
1902 3950
1903 3885
1904 4057
1905 4067
1906 3872
1907 4323
1908 4459
1909 4687
1910 4799
1911 5007
1912 4906
1913 5107
1914 5135
1915 4641
1916 4544
1917 4281
1918 4567
1919 4619
1920 4960
1921 4628
1922 4123
1923 4434
1924 4851
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5548
1933 5567
1934 5506
1935 5661
1936 5384
1937 5309
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20422
1946 53739
1947 64968
1948 70729
1949 62807
1950 85750
1951 103810
1952 108147
1953 108914
1954 105913
1955 108541
1956 107005
1957 111515
1958 109458
1959 109989
1960 112211
1961 120166
1962 125670
1963 141520
1964 162087
1965 176642
1966 179754
1967 191501
1968 207845
1969 215074
1970 218981
1971 222884
1972 227521
1973 230652
1974 234526
1975 248263
1976 250367
1977 249878
1978 258280
1979 265584
1980 267251
1981 271565
1982 283192
1983 294856
1984 302790
1985 319060
1986 331549
1987 347534
1988 364083
1989 378156
1990 383316
1991 381199
1992 382841
1993 390653
1994 402126
1995 411352
1996 421298
1997 419027
1998 436750
1999 453963
2000 491089
2001 503483
2002 521236
2003 548868
2004 592345
2005 650711
2006 697651
2007 733835
2008 781527
2009 821736
2010 884953
2011 961068
2012 1027144
2013 1078264
2014 1132408
2015 1175227
2016 1209139
2017 1232698
2018 1277411
2019 1338605
2020 1536123
2021 1680858
2022 1681544
2023 1596216
2024 1637352
2025 712352
2026 73
2027 1

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36,628,227 results

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Quoted phrases not found in phrase index: "Priority Journal", "Neurons Drug Effects Metabolism"
Page 1
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Israel MA, et al. Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821. Nature. 2012. PMID: 22278060 Free PMC article.
Neurons from APP(Dp) and sAD2 patients also accumulated large RAB5-positive early endosomes compared to controls. ...These results suggest a direct relationship between APP proteolytic processing, but not amyloid-beta, in GSK-3beta activation and tau phosphorylation in …
Neurons from APP(Dp) and sAD2 patients also accumulated large RAB5-positive early endosomes compared to controls. ...These results su …
The preparation of primary cortical neuron cultures and a practical application using immunofluorescent cytochemistry.
Sciarretta C, Minichiello L. Sciarretta C, et al. Methods Mol Biol. 2010;633:221-31. doi: 10.1007/978-1-59745-019-5_16. Methods Mol Biol. 2010. PMID: 20204631
Traditionally, cultures of primary cortical neurons are prepared from embryonic animals because at prenatal stages neurons have not yet developed extensive axonal and dendritic arbors and are not highly innervated, thus rendering the cells less susceptible to damage …
Traditionally, cultures of primary cortical neurons are prepared from embryonic animals because at prenatal stages neurons hav …
Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: a model for neuronal and synaptic differentiation in neurodegeneration.
Targett IL, Crompton LA, Conway ME, Craig TJ. Targett IL, et al. In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1058-1067. doi: 10.1007/s11626-024-00948-6. Epub 2024 Jul 17. In Vitro Cell Dev Biol Anim. 2024. PMID: 39017752 Free PMC article.
There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell (hiPSC)-derived neurones respectively. The human neuroblastoma cell line, SH-SY5Y, is ext …
There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and …
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol.
Wang H, Kulas JA, Wang C, Holtzman DM, Ferris HA, Hansen SB. Wang H, et al. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2102191118. doi: 10.1073/pnas.2102191118. Proc Natl Acad Sci U S A. 2021. PMID: 34385305 Free PMC article.
Treatment with cholesterol-free apoE or knockdown of cholesterol synthesis in astrocytes decreases cholesterol levels in cultured neurons and causes APP to traffic out of lipid clusters, where it interacts with alpha-secretase and gives rise to soluble APP-alpha (sA …
Treatment with cholesterol-free apoE or knockdown of cholesterol synthesis in astrocytes decreases cholesterol levels in cultured …
Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.
Mukherjee A, Song E, Kihiko-Ehmann M, Goodman JP Jr, Pyrek JS, Estus S, Hersh LB. Mukherjee A, et al. J Neurosci. 2000 Dec 1;20(23):8745-9. doi: 10.1523/JNEUROSCI.20-23-08745.2000. J Neurosci. 2000. PMID: 11102481 Free PMC article.
None of the products appeared to be further metabolized by insulysin. Using a rat cortical cell system, the action of insulysin on Abeta(1-40) and Abeta(1-42) was shown to eliminate the neurotoxic effects of these peptides. Insulysin was further shown to prev …
None of the products appeared to be further metabolized by insulysin. Using a rat cortical cell system, the action of insulysin …
Pioglitazone prevents tau oligomerization.
Hamano T, Shirafuji N, Makino C, Yen SH, Kanaan NM, Ueno A, Suzuki J, Ikawa M, Matsunaga A, Yamamura O, Kuriyama M, Nakamoto Y. Hamano T, et al. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1035-42. doi: 10.1016/j.bbrc.2016.08.016. Epub 2016 Aug 16. Biochem Biophys Res Commun. 2016. PMID: 27543203
Neuronostatin regulates neuronal function and energetic metabolism in Alzheimer's disease in a GPR107-dependent manner.
Yang S, Tang Q, Zhang Y, Du Y, Zhao X, Mei F, Li Y. Yang S, et al. Neuropharmacology. 2024 Nov 1;258:110090. doi: 10.1016/j.neuropharm.2024.110090. Epub 2024 Jul 22. Neuropharmacology. 2024. PMID: 39048031
However, the metabolism and function of NST in neurons of AD mice are not known. In this study, by combining the structural analyses, primary cultures, knockout cells, and various assessments, the behavior, histopathology, brain-wide expression and cellular signaling pathw …
However, the metabolism and function of NST in neurons of AD mice are not known. In this study, by combining the structural analyses, …
The release and transmission of amyloid precursor protein via exosomes.
Zheng T, Wu X, Wei X, Wang M, Zhang B. Zheng T, et al. Neurochem Int. 2018 Mar;114:18-25. doi: 10.1016/j.neuint.2017.12.009. Epub 2017 Dec 23. Neurochem Int. 2018. PMID: 29277576
Amyloid precursor protein (APP) processing is central in Alzheimer's disease (AD) pathogenesis. The healthy unaffected neurons suffer the transmission of amyloid protein from pathologically affected neurons, which may play an important role in the anatomical spread …
Amyloid precursor protein (APP) processing is central in Alzheimer's disease (AD) pathogenesis. The healthy unaffected neurons suffer …
36,628,227 results
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