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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 51
1993 181
1994 227
1995 293
1996 264
1997 285
1998 379
1999 361
2000 397
2001 447
2002 430
2003 392
2004 456
2005 500
2006 499
2007 523
2008 491
2009 495
2010 517
2011 501
2012 484
2013 486
2014 499
2015 497
2016 453
2017 459
2018 467
2019 235
2020 2
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10,339 results
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Alternative splicing as a regulator of development and tissue identity.
Baralle FE and Giudice J. Nat Rev Mol Cell Biol 2017 - Review. PMID 28488700 Free PMC article.
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. ...
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a lim
Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.
Kahles A, et al. Cancer Cell 2018. PMID 30078747 Free article.
Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30% more alternative splicing events than normal samples. Association analysis of somatic variants with alternative splicing events confirmed known trans associations with variants in SF3B1 and U2AF1 and identified additional trans-acting variants (e.g., TADA1, PPP2R1A). ...
Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects …
Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.
Urbanski LM, et al. Wiley Interdiscip Rev RNA 2018 - Review. PMID 29693319 Free PMC article.
Defects in alternative splicing are frequently found in human tumors and result either from mutations in splicing-regulatory elements of specific cancer genes or from changes in the regulatory splicing machinery. ...This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Processing > Splicing Regulation/Alternative Splicing....
Defects in alternative splicing are frequently found in human tumors and result either from mutations in splicing-regul …
Alternative Splicing May Not Be the Key to Proteome Complexity.
Tress ML, et al. Trends Biochem Sci 2017 - Review. PMID 27712956 Free PMC article.
Alternative splicing is commonly believed to be a major source of cellular protein diversity. However, although many thousands of alternatively spliced transcripts are routinely detected in RNA-seq studies, reliable large-scale mass spectrometry-based proteomics analyses identify only a small fraction of annotated alternative isoforms. ...Indeed, most alternative exons do not seem to be under selective pressure, suggesting that a large majority of predicted alternative transcripts may not even be translated into proteins....
Alternative splicing is commonly believed to be a major source of cellular protein diversity. However, although many thousands
The neurogenetics of alternative splicing.
Vuong CK, et al. Nat Rev Neurosci 2016 - Review. PMID 27094079 Free PMC article.
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. ...
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by speciali
The Functional Impact of Alternative Splicing in Cancer.
Climente-González H, et al. Cell Rep 2017. PMID 28854369 Free article.
Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. ...We propose that a subset of the alternative splicing changes observed in tumors may represent independent oncogenic processes that could be relevant to explain the functional transformations in cancer, and some of them could potentially be considered alternative splicing drivers (AS drivers)....
Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for t
Function of alternative splicing.
Kelemen O, et al. Gene 2013 - Review. PMID 22909801 Free PMC article.
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has profound functional effects. ...
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative
Alternative splicing and the evolution of phenotypic novelty.
Bush SJ, et al. Philos Trans R Soc Lond B Biol Sci 2017 - Review. PMID 27994117 Free PMC article.
Genes with developmental functions are enriched for alternative splicing events, suggestive of a contribution of alternative splicing to developmental programmes. ...Alternative splicing is reduced following gene duplication with the retention of duplicate copies higher for genes which were alternatively spliced prior to duplication. ...
Genes with developmental functions are enriched for alternative splicing events, suggestive of a contribution of alternativ
Alternative Splicing in Angiogenesis.
Bowler E and Oltean S. Int J Mol Sci 2019 - Review. PMID 31027366 Free PMC article.
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. ...Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1α, Angiopoietin-1 and Angiopoietin-2....
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct
The Expanding Landscape of Alternative Splicing Variation in Human Populations.
Park E, et al. Am J Hum Genet 2018 - Review. PMID 29304370 Free PMC article.
Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be greatly expanded. Genomic variants in splicing regulatory sequences can disrupt splicing and cause disease. Recent developments in sequencing technologies and computational biology have allowed researchers to investigate alternative splicing at an unprecedented scale and resolution. ...
Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be
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