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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 4
1993 10
1994 33
1995 45
1996 44
1997 46
1998 135
1999 127
2000 207
2001 201
2002 200
2003 191
2004 272
2005 262
2006 243
2007 278
2008 245
2009 248
2010 259
2011 267
2012 255
2013 251
2014 236
2015 233
2016 253
2017 210
2018 250
2019 119
2020 1
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4,659 results
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Alternative splicing as a regulator of development and tissue identity.
Baralle FE and Giudice J. Nat Rev Mol Cell Biol 2017 - Review. PMID 28488700 Free PMC article.
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. ...
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a lim
Alternative Splicing May Not Be the Key to Proteome Complexity.
Tress ML, et al. Trends Biochem Sci 2017 - Review. PMID 27712956 Free PMC article.
Alternative splicing is commonly believed to be a major source of cellular protein diversity. However, although many thousands of alternatively spliced transcripts are routinely detected in RNA-seq studies, reliable large-scale mass spectrometry-based proteomics analyses identify only a small fraction of annotated alternative isoforms. ...Indeed, most alternative exons do not seem to be under selective pressure, suggesting that a large majority of predicted alternative transcripts may not even be translated into proteins....
Alternative splicing is commonly believed to be a major source of cellular protein diversity. However, although many thousands
The Functional Impact of Alternative Splicing in Cancer.
Climente-González H, et al. Cell Rep 2017. PMID 28854369 Free article.
Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. ...We propose that a subset of the alternative splicing changes observed in tumors may represent independent oncogenic processes that could be relevant to explain the functional transformations in cancer, and some of them could potentially be considered alternative splicing drivers (AS drivers)....
Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for t
A survey of best practices for RNA-seq data analysis
Conesa A, et al. Genome Biol 2016 - Review. PMID 26813401 Free PMC article.
We review all of the major steps in RNA-seq data analysis, including experimental design, quality control, read alignment, quantification of gene and transcript levels, visualization, differential gene expression, alternative splicing, functional analysis, gene fusion detection and eQTL mapping. ...
We review all of the major steps in RNA-seq data analysis, including experimental design, quality control, read alignment, quantification of …
The Expanding Landscape of Alternative Splicing Variation in Human Populations.
Park E, et al. Am J Hum Genet 2018 - Review. PMID 29304370 Free PMC article.
Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be greatly expanded. ...We summarize major findings from population transcriptomic studies of alternative splicing and discuss the implications of these findings for human genetics and medicine....
Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be
Alternative splicing isoforms in health and disease.
Kim HK, et al. Pflugers Arch 2018 - Review. PMID 29536164
Alternative splicing (AS) of protein-coding messenger RNAs is an essential regulatory mechanism in eukaryotic gene expression that controls the proper function of proteins. ...Considering that mis-splicing can result in various human diseases by modifying or abrogating important physiological protein functions, a fine-tuned balance of AS is essential for human health. ...
Alternative splicing (AS) of protein-coding messenger RNAs is an essential regulatory mechanism in eukaryotic gene expression
Understanding alternative splicing: towards a cellular code.
Matlin AJ, et al. Nat Rev Mol Cell Biol 2005 - Review. PMID 15956978
In violation of the 'one gene, one polypeptide' rule, alternative splicing allows individual genes to produce multiple protein isoforms - thereby playing a central part in generating complex proteomes. Alternative splicing also has a largely hidden function in quantitative gene control, by targeting RNAs for nonsense-mediated decay. ...
In violation of the 'one gene, one polypeptide' rule, alternative splicing allows individual genes to produce multiple protein …
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches.
Chen M and Manley JL. Nat Rev Mol Cell Biol 2009 - Review. PMID 19773805 Free PMC article.
Alternative splicing of mRNA precursors provides an important means of genetic control and is a crucial step in the expression of most genes. Alternative splicing markedly affects human development, and its misregulation underlies many human diseases. Although the mechanisms of alternative splicing have been studied extensively, until the past few years we had not begun to realize fully the diversity and complexity of alternative splicing regulation by an intricate protein-RNA network. ...
Alternative splicing of mRNA precursors provides an important means of genetic control and is a crucial step in the expression
Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop.
Sterne-Weiler T, et al. Mol Cell 2018. PMID 30220560 Free article.
Alternative splicing (AS) is a widespread process underlying the generation of transcriptomic and proteomic diversity and is frequently misregulated in human disease. ...We observe that high-entropy AS events are more prevalent in tumor relative to matched normal tissues and correlate with increased expression of proto-oncogenic splicing factors. ...
Alternative splicing (AS) is a widespread process underlying the generation of transcriptomic and proteomic diversity and is f
The hnRNP family: insights into their role in health and disease
Geuens T, et al. Hum Genet 2016 - Review. PMID 27215579 Free PMC article.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. ...
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspect …
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