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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1792 1
1802 1
1827 1
1837 1
1842 4
1843 1
1844 3
1845 3
1846 5
1847 2
1848 2
1850 2
1852 3
1853 3
1854 3
1855 2
1856 5
1858 2
1859 3
1860 1
1861 2
1864 3
1865 2
1866 5
1867 3
1868 6
1869 1
1870 9
1871 5
1872 15
1873 20
1874 2
1875 8
1876 6
1877 10
1878 6
1879 6
1880 11
1881 13
1882 5
1883 11
1884 8
1885 12
1886 8
1887 10
1888 13
1889 9
1890 10
1891 10
1892 12
1893 6
1894 7
1895 7
1896 11
1897 10
1898 5
1899 4
1900 8
1901 5
1902 4
1903 13
1904 6
1905 22
1906 6
1907 14
1908 16
1909 22
1910 13
1911 13
1912 22
1913 21
1914 30
1915 19
1916 16
1917 15
1918 7
1919 10
1920 11
1921 22
1922 17
1923 12
1924 18
1925 24
1926 35
1927 29
1928 32
1929 28
1930 48
1931 61
1932 38
1933 47
1934 55
1935 40
1936 42
1937 33
1938 31
1939 61
1940 26
1941 31
1942 16
1943 22
1944 17
1945 170
1946 408
1947 472
1948 640
1949 521
1950 777
1951 961
1952 943
1953 942
1954 991
1955 997
1956 917
1957 1016
1958 949
1959 1009
1960 1000
1961 1173
1962 1201
1963 1723
1964 2088
1965 1680
1966 1477
1967 1726
1968 2038
1969 2085
1970 2281
1971 2396
1972 2526
1973 2598
1974 2595
1975 3013
1976 3147
1977 3164
1978 3205
1979 3309
1980 3385
1981 3504
1982 3519
1983 3985
1984 4312
1985 4580
1986 4985
1987 5173
1988 5351
1989 6200
1990 6342
1991 6575
1992 6821
1993 7023
1994 7527
1995 7984
1996 8560
1997 9050
1998 9397
1999 9870
2000 10808
2001 11301
2002 11922
2003 13088
2004 14103
2005 15339
2006 16932
2007 17902
2008 18989
2009 20056
2010 21975
2011 24106
2012 25614
2013 27396
2014 28723
2015 29971
2016 30802
2017 32005
2018 33384
2019 35804
2020 40447
2021 43478
2022 43809
2023 44128
2024 15838

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738,181 results

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Page 1
The essential elements of Alzheimer's disease.
Lei P, Ayton S, Bush AI. Lei P, et al. J Biol Chem. 2021 Jan-Jun;296:100105. doi: 10.1074/jbc.REV120.008207. Epub 2020 Nov 27. J Biol Chem. 2021. PMID: 33219130 Free PMC article. Review.
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are several other neurochemical abnormalities that occur in the AD brain tha …
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque neuropathology are yet to …
The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators.
Chen LL, Fan YG, Zhao LX, Zhang Q, Wang ZY. Chen LL, et al. Bioorg Chem. 2023 Feb;131:106301. doi: 10.1016/j.bioorg.2022.106301. Epub 2022 Nov 25. Bioorg Chem. 2023. PMID: 36455485 Review.
Alzheimer's disease (AD), characterized by the beta-amyloid protein (Abeta) deposition and tau hyperphosphorylation, is the most common dementia with uncertain etiology. ...Further studies uncovered that iron, copper and zinc could not only enha
Alzheimer's disease (AD), characterized by the beta-amyloid protein (Abeta) deposition and tau hyperphosphorylat
Copper and Alzheimer's Disease.
Mathys ZK, White AR. Mathys ZK, et al. Adv Neurobiol. 2017;18:199-216. doi: 10.1007/978-3-319-60189-2_10. Adv Neurobiol. 2017. PMID: 28889269 Review.
Alzheimer's disease (AD) is the most common form of adult neurode-generation and is characterised by progressive loss of cognitive function leading to death. ...Of the latter, major changes in copper (Cu) levels and localisation have been identified in
Alzheimer's disease (AD) is the most common form of adult neurode-generation and is characterised by progressive loss o
Copper-mediated beta-amyloid toxicity and its chelation therapy in Alzheimer's disease.
Singh SK, Balendra V, Obaid AA, Esposto J, Tikhonova MA, Gautam NK, Poeggeler B. Singh SK, et al. Metallomics. 2022 Jun 13;14(6):mfac018. doi: 10.1093/mtomcs/mfac018. Metallomics. 2022. PMID: 35333348 Review.
KEYWORDS: Short Twitter Statement: Authors explore copper ion interaction w/ Abeta and kinetics of fibril formation in promoting amyloid-beta mediated cell toxicity in Alzheimer's disease and the potential use of copper chelators in the p …
KEYWORDS: Short Twitter Statement: Authors explore copper ion interaction w/ Abeta and kinetics of fibril formation in promoting a
Commonalities between Copper Neurotoxicity and Alzheimer's Disease.
Patel R, Aschner M. Patel R, et al. Toxics. 2021 Jan 7;9(1):4. doi: 10.3390/toxics9010004. Toxics. 2021. PMID: 33430181 Free PMC article. Review.
Alzheimer's disease is caused by elevated levels of heavy metals, such as lead, zinc, and copper. Copper is found in many areas of daily life, raising a concern as to how this metal and Alzheimer's disease are related. ...
Alzheimer's disease is caused by elevated levels of heavy metals, such as lead, zinc, and copper. Copper
Copper and Zinc Dysregulation in Alzheimer's Disease.
Sensi SL, Granzotto A, Siotto M, Squitti R. Sensi SL, et al. Trends Pharmacol Sci. 2018 Dec;39(12):1049-1063. doi: 10.1016/j.tips.2018.10.001. Epub 2018 Oct 20. Trends Pharmacol Sci. 2018. PMID: 30352697 Review.
Alzheimer's disease (AD) is one of the most common forms of dementia. ...In this review, we focus on the role of AD-related neurodegeneration and cognitive decline triggered by the imbalance of two endogenous metals: copper and zinc....
Alzheimer's disease (AD) is one of the most common forms of dementia. ...In this review, we focus on the role of AD-rel
Role of metals in Alzheimer's disease.
Das N, Raymick J, Sarkar S. Das N, et al. Metab Brain Dis. 2021 Oct;36(7):1627-1639. doi: 10.1007/s11011-021-00765-w. Epub 2021 Jul 27. Metab Brain Dis. 2021. PMID: 34313926 Review.
Thus, exploration of metal biology in relation to neurodegenerative pathology is essential in pursuing novel therapies for Alzheimer's Disease and other neurodegenerative disorders. This review covers mechanisms of action of aluminum, iron, copper, and …
Thus, exploration of metal biology in relation to neurodegenerative pathology is essential in pursuing novel therapies for Alzheimer' …
Role of Copper in the Onset of Alzheimer's Disease Compared to Other Metals.
Bagheri S, Squitti R, Haertlé T, Siotto M, Saboury AA. Bagheri S, et al. Front Aging Neurosci. 2018 Jan 23;9:446. doi: 10.3389/fnagi.2017.00446. eCollection 2017. Front Aging Neurosci. 2018. PMID: 29472855 Free PMC article. Review.
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid plaques in patients' brain tissue. ...The involvement of copper in AD is controversial, as some studies show a copper deficiency in AD, and conseque
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid plaques in patients' b
Metallostasis in Alzheimer's disease.
Ayton S, Lei P, Bush AI. Ayton S, et al. Free Radic Biol Med. 2013 Sep;62:76-89. doi: 10.1016/j.freeradbiomed.2012.10.558. Epub 2012 Nov 9. Free Radic Biol Med. 2013. PMID: 23142767 Review.
2012 has been another year in which multiple large-scale clinical trials for Alzheimer's disease (AD) have failed to meet their clinical endpoints. ...The metal hypothesis is built upon a triad of transition elements: iron, copper, and zinc. The hypoth …
2012 has been another year in which multiple large-scale clinical trials for Alzheimer's disease (AD) have failed to me …
738,181 results
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