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[No authors listed] Am J Physiol Gastrointest Liver Physiol 2019. PMID 31393786
Homeostasis of the gut barrier and potential biomarkers
Wells JM, et al. Am J Physiol Gastrointest Liver Physiol 2017 - Review. PMID 27908847 Free PMC article.
However, perturbation of gut barrier homeostasis can lead to increased inflammatory signaling, increased epithelial permeability, and dysbiosis of the microbiota, which are recognized to play a role in the pathophysiology of a variety of gastrointestinal disorders. ...
However, perturbation of gut barrier homeostasis can lead to increased inflammatory signaling, increased epithelial permeability, and dysbio …
The liver in regulation of iron homeostasis.
Rishi G and Subramaniam VN. Am J Physiol Gastrointest Liver Physiol 2017 - Review. PMID 28596277 Free article.
The liver is one of the largest and most functionally diverse organs in the human body. In addition to roles in detoxification of xenobiotics, digestion, synthesis of important plasma proteins, gluconeogenesis, lipid metabolism, and storage, the liver also plays a significant role in iron homeostasis. ...This hepatic iron-regulatory function can be attributed to the expression of many liver-specific or liver-enriched proteins, all of which play an important role in the regulation of iron homeostasis. ...
The liver is one of the largest and most functionally diverse organs in the human body. In addition to roles in detoxification of xen …
Irritable bowel syndrome: a gut microbiota-related disorder?
Bhattarai Y, et al. Am J Physiol Gastrointest Liver Physiol 2017 - Review. PMID 27881403 Free PMC article.
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders. Despite its prevalence, the pathophysiology of IBS is not well understood although multiple peripheral and central factors are implicated. ...
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders. Despite its prevalence, the pathophysiology …
Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either.
Hartmann P, et al. Am J Physiol Gastrointest Liver Physiol 2019 - Review. PMID 30767680 Free PMC article.
Complete absence of intestinal microbiota as in germ-free rodents can be protective in autoimmune hepatitis and hepatic tumors induced by chemicals, or it can exacerbate disease as in acute toxic liver injury and liver fibrosis/cirrhosis. In alcoholic liver disease, nonalcoholic fatty liver disease, and autoimmune cholangiopathies, germ-free status can be associated with worsened or improved hepatic phenotype depending on the experimental model and type of rodent. ...
Complete absence of intestinal microbiota as in germ-free rodents can be protective in autoimmune hepatitis and hepatic tumors induced by ch …
cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING.
Lei Z, et al. Am J Physiol Gastrointest Liver Physiol 2018. PMID 29446653 Free PMC article.
However, little is known about the role of cGAS/STING in liver I/R injury. We subjected C57BL/6 (WT), cGAS knockout (cGAS(-/-)), and STING-deficient (STING(gt/gt)) mice to warm liver I/R injury and that found cGAS(-/-) mice had significantly increased liver injury compared with WT or STING(gt/gt) mice, suggesting a protective effect of cGAS independent of STING. ...Specifically, we provide evidence that cGAS protects liver from I/R injury in a STING-independent manner....
However, little is known about the role of cGAS/STING in liver I/R injury. We subjected C57BL/6 (WT), cGAS knockout (cGAS(-/-)), and …
Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals.
Suppli MP, et al. Am J Physiol Gastrointest Liver Physiol 2019. PMID 30653341
RNA sequencing and quantitative histomorphometry of liver fat, inflammation and fibrosis were performed on liver biopsies obtained from healthy normal-weight ( n = 14) and obese ( n = 12) individuals, NAFL ( n = 15) and NASH ( n = 16) patients. ...NEW & NOTEWORTHY Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries. NAFLD is associated with the metabolic syndrome and can progress to the more serious form, nonalcoholic steatohepatitis (NASH), and ultimately lead to irreversible liver damage. ...
RNA sequencing and quantitative histomorphometry of liver fat, inflammation and fibrosis were performed on liver biopsies obta …
Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface
Wallace JL, et al. Am J Physiol Gastrointest Liver Physiol 2018 - Review. PMID 29025733 Free PMC article.
Hydrogen sulfide (H(2)S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defense and repair. ...H(2)S donors can modify the gut microbiota, and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H(2)S. ...
Hydrogen sulfide (H(2)S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal def …
Live cell imaging of cytosolic NADH/NAD(+) ratio in hepatocytes and liver slices.
Masia R, et al. Am J Physiol Gastrointest Liver Physiol 2018. PMID 29025729 Free PMC article.
Fatty liver disease (FLD), the most common chronic liver disease in the United States, may be caused by alcohol or the metabolic syndrome. ...Imaging in liver slices is particularly attractive because it allows preservation of liver microanatomy and metabolic zonation of hepatocytes. ...
Fatty liver disease (FLD), the most common chronic liver disease in the United States, may be caused by alcohol or the metabol …
Helminths in the gastrointestinal tract as modulators of immunity and pathology.
Varyani F, et al. Am J Physiol Gastrointest Liver Physiol 2017 - Review. PMID 28302598 Free PMC article.
Many of the most common helminths establish themselves in the gastrointestinal tract and can exert counter-inflammatory influences on the host immune system. ...
Many of the most common helminths establish themselves in the gastrointestinal tract and can exert counter-inflammatory influences on …
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