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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1975 16
1976 14
1977 32
1978 14
1979 29
1980 36
1981 30
1982 26
1983 30
1984 25
1985 23
1986 27
1987 18
1988 18
1989 20
1990 36
1991 34
1992 20
1993 36
1994 33
1995 38
1996 67
1997 88
1998 151
1999 172
2000 214
2001 221
2002 183
2003 175
2004 159
2005 150
2006 145
2007 123
2008 92
2009 104
2010 83
2011 74
2012 93
2013 87
2014 71
2015 66
2016 71
2017 62
2018 43
2019 18
2020 1
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3,083 results
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Page 1
The asymmetric distribution of enzymic activity between the six subunits of bovine liver glutamate dehydrogenase. Use of D- and L-glutamyl alpha-chloromethyl ketones (4-amino-6-chloro-5-oxohexanoic acid.
Rasool CG, et al. Biochem J 1976. PMID 10889 Free PMC article.
A method for the preparation of D- and L-glutamyl alpha-chloromethyl ketones (4-amino-6-chloro-5-oxohexanoic acid) is described. ...
A method for the preparation of D- and L-glutamyl alpha-chloromethyl ketones (4-amino-6-chloro-5-oxohexanoic acid) is describe …
Zymogen/enzyme discrimination using peptide chloromethyl ketones
Williams EB, et al. J Biol Chem 1989. PMID 2708377 Free article.
Glutamylglycinylarginyl chloromethyl ketone, tyrosylglycinylarginyl chloromethyl ketone, and phenylalanylprolylarginyl chloromethyl ketone have been labeled at their amino termini using fluorescein, rhodamine-X, lissamine-rhodamine, pyrene, and the 1,5-, 2,5-, and 2,6-dimethylaminonaphthalene-1-sulfonyl moieties. ...When enzymes were modified using chloromethyl ketones labeled with epsilon-amino caproyl biotin, the modified proteins readily reacted with avidin under a variety of different conditions. ...
Glutamylglycinylarginyl chloromethyl ketone, tyrosylglycinylarginyl chloromethyl ketone, and phenylalanylprolylarginyl chloromethyl ketone h …
[Membrane-bound alanine aminopeptidase from Acinetobacter calcoaceticus. 4. Amino acid chloromethyl ketones as pH-dependent, substrate-derived inhibitors of cysteine protease].
Jahreis G and Aurich H. Biomed Biochim Acta 1991. PMID 1686704 German.
Amino acid chloromethyl ketones are highly specific inhibitors of the enzyme. The AAP is inhibited at pH 7.5 (pH-optimum) by mixed-type inhibition. ...
Amino acid chloromethyl ketones are highly specific inhibitors of the enzyme. The AAP is inhibited at pH 7.5 (pH-optimum) by m
Selective effects of two chloromethyl ketones on amino acid and phosphate uptake in rat liver and tumors.
Lea MA and Koch MR. J Natl Cancer Inst 1979. PMID 281572
Injection of L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK) at a level of 10 mg/100 g body weight inhibited the incorporation of 3H-labeled amino acids into protein in Morris hepatomas 7777and 9618A2. ...There was no inhibitory effect on 3H-labeled amino acid incorporation in the livers of the tumor-bearing rats. The inhibitory effect of N-tosyl-L-lysine chloromethyl ketone (TLCK) on incorporation of 3H-labeled amino acids was observed in both the slowly growing hepatoma 7787 and the rapidly growing hepatoma 7777. ...
Injection of L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK) at a level of 10 mg/100 g body weight inhibited the incorporation of 3H …
Accumulation of amino acids by lysosomes incubated with amino acid methyl esters.
Reeves JP. J Biol Chem 1979. PMID 479167 Free article.
The capacity to accumulate leucine was identified as a specific property of lysosomes and was thought to result from the trapping of the free amino acid within the lysosome following the hydrolysis of the methyl ester. ...The results provide a new methodology for the study of amino acid movements across lysosomal membranes....
The capacity to accumulate leucine was identified as a specific property of lysosomes and was thought to result from the trapping of the fre …
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