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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 52
1946 194
1947 310
1948 238
1949 230
1950 323
1951 315
1952 405
1953 426
1954 522
1955 478
1956 437
1957 531
1958 584
1959 618
1960 640
1961 701
1962 894
1963 1103
1964 1687
1965 1650
1966 1435
1967 2018
1968 2628
1969 3014
1970 3164
1971 3371
1972 3456
1973 3529
1974 3556
1975 3302
1976 3067
1977 2911
1978 2561
1979 2665
1980 2483
1981 2441
1982 2358
1983 2360
1984 2303
1985 2343
1986 2357
1987 2252
1988 2181
1989 2348
1990 2289
1991 2198
1992 2027
1993 1934
1994 1832
1995 1756
1996 1599
1997 1565
1998 1572
1999 1561
2000 1722
2001 1927
2002 1968
2003 2082
2004 2140
2005 2192
2006 2237
2007 2475
2008 2418
2009 2347
2010 2353
2011 2526
2012 2681
2013 2676
2014 2656
2015 2606
2016 2536
2017 2496
2018 2451
2019 1359
2020 59
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136,009 results
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Page 1
Amino Acids and Hypertension in Adults.
Poggiogalle E, et al. Nutrients 2019 - Review. PMID 31252583 Free PMC article.
The aim of the present review was to summarize epidemiological evidence concerning the connection between amino acids and hypertension. ...Indeed, some classes of amino acids or individual amino acids showed non-causative association with blood pressure as well as the incidence of hypertension, but the evidence was far from being conclusive. ...
The aim of the present review was to summarize epidemiological evidence concerning the connection between amino acids and hype …
Impact of Supplementary Amino Acids, Micronutrients, and Overall Diet on Glutathione Homeostasis.
Gould RL and Pazdro R. Nutrients 2019 - Review. PMID 31083508 Free PMC article.
Oral GSH supplementation is not the most efficient option due to the enzymatic degradation of ingested GSH within the intestine by γ-glutamyltransferase, but supplementation of its component amino acids-cysteine, glycine, and glutamate-enhances tissue GSH synthesis. Furthermore, supplementation with some non-precursor amino acids and micronutrients appears to influence the redox status of GSH and related antioxidants, such as vitamins C and E, lowering systemic oxidative stress and slowing the rate of tissue deterioration. ...
Oral GSH supplementation is not the most efficient option due to the enzymatic degradation of ingested GSH within the intestine by γ-glutamy …
Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination.
Steinfeld JB, et al. Genes Dev 2019. PMID 31371435 Free PMC article.
Chimeric Rad51 mutants harboring Dmc1-specific amino acids gain the ability to stabilize heteroduplex DNA joints with mismatch-containing base triplets, whereas Dmc1 mutants with Rad51-specific amino acids lose this ability. Remarkably, RAD-51 from Caenorhabditis elegans, an organism without Dmc1, has acquired "Dmc1-like" amino acids. Chimeric C. elegans RAD-51 harboring "canonical" Rad51 amino acids gives rise to toxic recombination intermediates, which must be actively dismantled to permit normal meiotic progression. ...
Chimeric Rad51 mutants harboring Dmc1-specific amino acids gain the ability to stabilize heteroduplex DNA joints with mismatch …
Intracellular accumulation of amino acids increases synaptic potentials in rat hippocampal slices.
Luengo JG, et al. Amino Acids 2019. PMID 31428912
The magnitude of the potentiation caused by some of these amino acids was even greater than that induced by taurine. By contrast, the application of other amino acids (L-arginine, betaine, L-leucine, L-methionine, L- and D-proline, and L-valine) did not induce potentiation. The behaviour of these different amino acids on synaptic potentiation is not compatible with a role of PAT1 in synaptic potentiation. ...
The magnitude of the potentiation caused by some of these amino acids was even greater than that induced by taurine. By contra …
Mitochondrial Carriers for Aspartate, Glutamate and Other Amino Acids: A Review.
Monné M, et al. Int J Mol Sci 2019 - Review. PMID 31510000 Free PMC article.
MC substrates consist of metabolites, inorganic anions (such as phosphate and sulfate), nucleotides, cofactors and amino acids. ...Aside from providing amino acids for mitochondrial translation, the transport reactions catalyzed by these MCs are crucial in energy, nitrogen, nucleotide and amino acid metabolism. ...
MC substrates consist of metabolites, inorganic anions (such as phosphate and sulfate), nucleotides, cofactors and amino acids
Electrosynthesis of amino acids from biomass-derivable acids on titanium dioxide.
Fukushima T and Yamauchi M. Chem Commun (Camb) 2019. PMID 31670353
Seven amino acids were electrochemically synthesized from biomass-derivable α-keto acids and NH2OH with faradaic efficiencies (FEs) of 77-99% using an earth-abundant TiO2 catalyst. Furthermore, we newly constructed a flow-type electrochemical reactor, named a "polymer electrolyte amino acid electrosynthesis cell", and achieved continuous production of alanine with an FE of 77%....
Seven amino acids were electrochemically synthesized from biomass-derivable α-keto acids and NH2OH with faradaic effici …
Total synthesis of Escherichia coli with a recoded genome
Fredens J, et al. Nature 2019. PMID 31092918
Here we demonstrate that the number of codons used to encode the canonical amino acids can be reduced, through the genome-wide substitution of target codons by defined synonyms. ...Thus, we recode 18,214 codons to create an organism with a 61-codon genome; this organism uses 59 codons to encode the 20 amino acids, and enables the deletion of a previously essential transfer RNA....
Here we demonstrate that the number of codons used to encode the canonical amino acids can be reduced, through the genome-wide …
Amino acids disrupt calcium-dependent adhesion of stratum corneum.
Kim JH, et al. PLoS One 2019. PMID 30990830 Free PMC article.
In the current study, we verified the Ca2+ chelating property of amino acids and demonstrated that amino acids can interfere with the interaction of cadherins, separate stratum corneum into pieces, and thereby stimulate the exfoliation process of skin. ...Importantly, our findings indicate that amino acids may be efficiently used for improving skin conditions....
In the current study, we verified the Ca2+ chelating property of amino acids and demonstrated that amino acids c …
Quantitative amino acids profile of monofloral bee pollens by microwave hydrolysis and fluorimetric high performance liquid chromatography.
Themelis T, et al. J Pharm Biomed Anal 2019. PMID 31129534
In characterization of bee pollen with the aim to define its value in human nutrition, the amino acids profile is one of the most important attributes. ...Principal Component Analysis was applied to treat the obtained data, highlighting the importance for discrimination, of detecting low abundance amino acids. ...
In characterization of bee pollen with the aim to define its value in human nutrition, the amino acids profile is one of the m …
Metabolomics of Type 1 and Type 2 Diabetes
Arneth B, et al. Int J Mol Sci 2019 - Review. PMID 31109071 Free PMC article.
The results from the selected studies were used to assess the relationships between diabetes (T1D and/or T2D) and metabolite markers-such as glutamine, glycine, and aromatic amino acids-in patients. ...The evidence shows that metabolites such as glucose, fructose, amino acids, and lipids are typically altered in individuals with T1D and T2D. ...
The results from the selected studies were used to assess the relationships between diabetes (T1D and/or T2D) and metabolite markers-such as …
136,009 results
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